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Found 2923 clinical trials
Acute Effects of the Prostaglandin (Alprostadil) on Cerebral and Pulmonary Flow (Alprostadil)

The second stage operation towards single ventricle palliation is 'bidirectional cavopulmonary connection' (BCPC). The superior vena cava is connected to the pulmonary artery, diverting 'blue' blood from the upper body (including the brain) to the lungs. A successful BCPC requires sufficient and easy blood flow through the lungs. Alprostadil is …

single ventricle
  • 15 Feb, 2022
  • 1 location
Paravertebral Nerve Blocks in Neonates

This study is a prospective, randomized, non-blinded clinical trial examining the use of paravertebral peripheral nerve block in the neonatal and infant populations. The primary aim of this study is to determine the feasibility of studying whether a single-shot paravertebral nerve block is effective in providing intraoperative and postoperative pain …

postoperative pain
coarctation of the aorta
  • 21 Mar, 2022
  • 1 location
Role of ARNi in Ventricular Remodeling in Hypertensive LVH (REVERSE-LVH)

In Singapore, hypertension is very common in the adult population. Hypertensive heart disease is a leading cause of heart failure and cardiovascular death. Current management relies primarily on

  • 14 May, 2022
  • 1 location
Subcostal Transverse Abdominis Plane Block for Epigastric Cardiac Pacemaker Operation

This prospective randomized controlled trial aims to examine the effect of subcostal transverse abdominis plane block on the postoperative pain and opioid consumption in patients (12y≤ age) who will undergo epigastric cardiac pacemaker operation. Patients will be allocated to either the SC TAP(subcostal transverse abdominis plane block) group or the …

  • 19 Jun, 2022
  • 1 location
Dexmedetomidine Neuroprotection in Pediatric Cardiac Surgery

Neurodevelopmental disability is the most significant complication for survivors of infant surgery for congenital heart disease. In this study we sought to determine if intraoperative continuous

  • 25 Mar, 2022
  • 1 location
High-exchange ULTrafiltration to Enhance Recovery After Pediatric Cardiac Surgery

Malformations of the heart are common; 1.35 million infants are born each year with congenital heart disease. Many of these defects carry a considerable threat to the individual's quality of

  • 04 Nov, 2021
  • 1 location
ATC Vs PSV for Ventilatory Weaning of Pediatrics Postcardiac Surgery

The ventilator modality of automatic tube compensation (ATC) can provide variable pressure supports during the weaning process to overcome any change in the resistance of the breathing circuit, endotracheal tube, and airways. The aim of the study is to evaluate the automatic tube compensation (ATC) as a tool for ventilatory …

  • 18 May, 2022
  • 1 location
Acute Maternal Hyperoxygenation in CHD

Congenital heart disease (CHD) is predominantly detected before birth. Using echocardiography and MRI, this study will determine whether acute exposure to maternal hyperoxygenation (MH) leads to

tricuspid atresia
tetralogy of fallot
hypoplastic left heart syndrome
  • 06 Feb, 2022
  • 1 location
Exploring the Relationship Between Advanced Multimodal Brain MRI Phenotypes, Genes and Cognitive Outcome in Adults With CHD

The main purpose of this proposal is to perform novel MRI analyses to determine the brain organizational changes associated with altered executive function and the modulating role of variants in neuroresilience and hypoxia response genes in adults with d-transposition of the great arteries (d-TGA).

Accepts healthy volunteers
  • 16 Oct, 2022
  • 1 location
Training in Exercise Activities and Motion for Growth (TEAM 4 Growth) RCT (T4G RCT)

This is a Phase III randomized controlled trial of a passive ROM exercise program that will be performed in infants with HLHS and other single right ventricle anomalies following the Norwood procedure at PHN and Auxiliary Centers.

  • 04 Oct, 2022
  • 4 locations