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Found 12 clinical trials
Treatment of Egyptian Hepatitis C Genotype 4 Infected Children and Adolescents With Combined Ledipasvir/Sofosbuvir

investigate the safety & efficacy of combined therapy ledipasvir (LDV) and sofosbuvir (SOF) for treating HCV Genotype 4 in children aged 8 to 18. Due to previous positive results in other clinical studies

  • 3 views
  • 08 Nov, 2020
  • 1 location
Efficacy and Safety of All-Oral Combination of Narlaprevir/Ritonavir and Sofosbuvir in Treatment-na ve Patients With Chronic Hepatitis C Genotype 1

Multicenter, open-label, phase II safety and efficacy study of all-oral combination of narlaprevir/ritonavir and sofosbuvir in Treatment-nave Patients with Chronic Hepatitis C Genotype 1.

  • 0 views
  • 02 Feb, 2020
  • 5 locations
Re-treatment of HCV Following DAA Failure

clinical profile, based on the current empiric knowledge - the choice of drugs will be based on HCV genotype, the previous treatment regimen and the presence/absence of liver cirrhosis, etc.

velpatasvir
ribavirin
cirrhosis
liver disease
hcv genotype
  • 19 views
  • 08 Nov, 2020
  • 1 location
Treatment of Chronic Hepatitis C During Pregnancy With Sofosbuvir/Velpatasvir

A single-arm, single-center, open label Phase 1 study of a 12-week course of Sofosbuvir (SOF)/Velpatasvir (VEL) in 10 HCV-infected pregnant women 1 that will evaluate the plasma pharmacokinetic parameters of SOF/VEL administered during pregnancy and compare them to those of a historical cohort of nonpregnant women.

hepatitis b
sofosbuvir
velpatasvir
chronic hepatitis
  • 0 views
  • 02 Nov, 2020
  • 1 location
Thalidomide Plus Peginterferon and Ribavirin in Patients With Interferon Resistance

INDICATION: Patients with chronic hepatitis C, genotype 1 and non-responders to standard treatment for hepatitis C. OBJECTIVES: 1. ascertain the rate of sustained

peginterferon
ribavirin
chronic hepatitis
liver disease
interferon
  • 6 views
  • 07 Nov, 2020
  • 1 location
Sofosbuvir/Velpatasvir in Postpartum Women With Opioid Use Disorder and Chronic Hepatitis C Infection

, enrollment and a baseline assessment of liver function, HCV infection (genotype, viral load) and blood and urine studies in HCV-infected patients during pregnancy. In Phase 2, subjects will undergo 12 weeks

hepatitis b
sofosbuvir
velpatasvir
chronic hepatitis
  • 44 views
  • 19 Aug, 2020
  • 1 location
Treatment of Recently Acquired Hepatitis C With the 3D Regimen or G/P

An open label, multicentre, international pilot study of paritaprevir/ritonavir, ombitasvir, dasabuvir with or without ribavirin or glecaprevir/pibrentasvir for people with recently acquired hepatitis C virus infection with or without HIV co-infection.

  • 15 views
  • 09 Sep, 2020
  • 11 locations
Pegylated Interferon Alfa-2b Plus Ribavirin in Chronic Hepatitis B and Delta

The treatment of choice for chronic hepatitis D is uncertain. The investigators hypothesize that pegylated interferon (IFN) alfa-2b in combination with ribavirin (RBV) may be effective in the treatment of chronic hepatitis D patients who are also infected by hepatitis B virus (HBV). The purpose of this study is to …

peginterferon
ribavirin
chronic hepatitis
hepatitis b antigen
hepatitis d
  • 6 views
  • 07 Nov, 2020
  • 1 location
Switch to Genvoya Followed by HCV Therapy With Epclusa Followed by Simplification of HIV Therapy With Biktarvy in Patients With HIV-HCV Co-Infected Subjects on Opioid Substitution Therapy

The study hypothesis is to determine the feasibility of switching HIV-HCV co-infected patients receiving methadone or buprenorphine/naloxone as opioid substitution therapy with suppressed HIV RNA viral load on current antiretroviral therapy to elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF, Genvoya) followed by 12 weeks of HCV antiviral therapy with sofosbuvir/velpatasvir (SOF/VEL, Epclusa), followed then …

opiate substitution treatment
sofosbuvir/velpatasvir
opioid
buprenorphine
elvitegravir
  • 67 views
  • 30 Dec, 2019
  • 1 location
A Study of the Effectiveness and Clinical Practice Use of Glecaprevir/Pibrentasvir in Adolescents With Chronic Hepatitis C Genotypes 1 to 6 in Russian Federation

immunodeficiency virus (HIV) adolescents, in various HCV genotype/subgenotype, cirrhotic and non-cirrhotic participants, treatment-experienced (prior treatment with pegylated interferon (pegIFN) or IFN, and/or

ribavirin
cirrhosis
glecaprevir
pibrentasvir
interferon
  • 2 views
  • 12 Aug, 2020
  • 5 locations