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Found 57 clinical trials
The Efficacy and Safety of 12-week SOF/VEL Regimen Combined With Prophylactic Use of TAF for Treatment-na ve Genotype 1-6 HCV/HBV Co-infection Adult Patients With or Without Compensated Cirrhosis in China

Subjects can be classified into two groups, Group 1 include non-cirrhotic patients, Group 2 include cirrhotic patients. All the patients will be received prophylactically TAF for 4 weeks before using SOF/VEL once daily for 12 weeks. In total, Group 1 patients will be discontinued TAF once daily therapy at the …

ribavirin
hepatocellular carcinoma
tenofovir
antiviral therapy
antiviral agents
  • 0 views
  • 18 Aug, 2021
  • 1 location
A Phase III Randomized Trial of Prophylactic Antiviral Therapy in Patients With Current or Past Hepatitis B Virus (HBV) Infection Receiving Anti-Cancer Therapy for Solid Tumors

This phase III trial studies the effect of tenofovir alafenamide in preventing liver complications in patients with current or past hepatitis B virus (HBV) who are receiving anti-cancer therapy for solid tumors. People with chronic or past HBV who are undergoing therapy for cancer are at an increased risk for …

telbivudine
hysterectomy
fumarate
cancer
tenofovir
  • 17 views
  • 18 Oct, 2022
  • 114 locations
Utilization of Hepatitis B Virus Nucleic Acid Test Positive Donors for Hepatitis B Vaccinated Lung Transplant Candidates (INHIBITOR)

The objective of this study is to determine the safety and efficacy of transplanting lungs from hepatitis B virus (HBV) nucleic acid test positive (NAT+) donors into HBV vaccinated HBV surface antibody positive (sAb+) lung transplant candidates, who will then be treated with Hepatitis B Immune Globulin (HBIG) and entecavir, …

tenofovir
entecavir
hepatitis
hepatitis b immune globulin
  • 0 views
  • 22 Oct, 2022
  • 1 location
The Immune Responses After Hepatitis B Revaccination Doses in a Young Cohort (IRHBRVD)

This prospective cohort study aims to provide the evidence-based clinical guide to help decide the revaccination doses of hepatitis B vaccine that the high-risk young adults without hepatitis B seroprotective antibodies (anti-HBs titer<10 mIU/mL) need to take.

engerix-b
hepatitis
Accepts healthy volunteers
  • 0 views
  • 15 Jul, 2022
  • 1 location
BRE-04: Window of Opportunity Trial of Preoperative Low Dose Azacitidine in High-Risk Early Stage Breast Cancer (BRE-04)

To determine the effect of low dose azacitidine therapy on tumor infiltrating lymphocytes (TILs) in primary tumors from patients with high-risk early stage breast cancer, paired t-tests will be first used to compare TIL count in pre- and post-treatment specimens.

  • 0 views
  • 10 May, 2022
  • 1 location
PrEP Intervention for People Who Inject Substances and Use Methamphetamine (PRIME)

In this study, "PrEP Intervention for people who Inject Substances and Use Methamphetamine" (PRIME), we propose to assess if using video directly observed therapy with real-time contingency management (VDOT-CM) may help people assigned male sex at birth who have sex with men (MSM) who inject methamphetamine adhere to PrEP. We …

HIV Vaccine
emtricitabine
Accepts healthy volunteers
  • 0 views
  • 27 May, 2022
  • 1 location
Fecal Microbiota Therapy in Steroid Ineligible Alcoholic Hepatitis

Alcoholic hepatitis, the most florid form of alcoholic liver disease, has a very high short-term mortality of up to 50% and no specific therapies are available other than steroids. Steroids also only show a limited utility in improving the short-term survival and boast no evidence of any long-term benefits. Additionally, …

liver disease
  • 0 views
  • 30 Apr, 2022
  • 1 location
Dosimetry of Tc-99m-Tilmanocept

This proposal will use kidney SPECT/CT of Tc-99m-tilmanocept to evaluate the mesangial changes seen in diabetics across the spectrum of kidney disease as well as persons with hypertensive kidney disease, the next most common cause of kidney disease in patients with diabetes. We aim to demonstrate that these different disease …

diabetes
Accepts healthy volunteers
  • 0 views
  • 14 Mar, 2022
  • 1 location
Clinical Burden of Anemia in Inflammatory Bowel Disease: Therapeutic Trial

Anemia is the most common extraintestinal manifestation of inflammatory bowel diseases (IBD), Although most cases of anemia in IBD are due to iron deficiency, many patients with iron deficiency anemia (IDA) are not treated with iron supplementation. In addition, it has not been firmly established which iron supplementation modality provides …

fatigue
enteropathy
  • 0 views
  • 26 Jan, 2021
  • 1 location
Predictive Model for Prognosis of Chronic HBV Infection Mothers

and delivery are very limited. What are the factors that affect the clearance of HBeAg or HBsAg? What kind of antiviral treatment protocol should be adopted for mothers with CHB? It is not only a

  • 0 views
  • 29 Aug, 2021
  • 1 location