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Found 48 clinical trials
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Haplo-identical Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using Peripheral Blood Stem Cells and Post-Transplant Cyclophosphamide for GVHD Prophylaxis

Background: Severe aplastic anemia (SAA) and myelodysplastic syndrome (MD) cause serious blood problems. Stem cell transplants using bone marrow or blood plus chemotherapy can help. Researchers want to see if using peripheral blood stem cells (PBSCs) rather than bone marrow cells works too. PBSCs are easier to collect and have …

anemia
myelodysplastic syndrome (mds)
aplastic anemia
myelodysplastic syndromes
anemia studies
  • 57 views
  • 22 Dec, 2020
  • 1 location
Individualized Dose Study of ATG in Haploidentical Hematopoietic Stem Cell Transplantation

The purpose of this study is to determine the response and toxicity rate of two different dosages (Individualized dosage VS. fixed dosage) of ATG as a prophylaxis for acute GVHD in haploidentical peripheral blood stem cell transplantation (haplo-PBSCT).

  • 0 views
  • 12 Mar, 2021
  • 1 location
Risk Stratification-directed NAC for Prevention of Poor Hematopoietic Reconstitution

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment of malignant hematopoietic diseases. However, poor hematopoietic reconstitution including poor graft function (PGF) and prolonged isolated thrombocytopenia (PT), remains a life-threatening complication after allo-HSCT. Especially with the increasing use of haploidentical allo-HSCT (haplo-HSCT) in the past ten years, PGF and …

cell transplantation
remission
acute leukemia
n-acetylcysteine
  • 0 views
  • 26 Jan, 2021
  • 1 location
Matched Unrelated vs. Haploidentical Donor for Allogeneic Stem Cell Transplantation in Patients With Acute Leukemia

leukemia in complete remission between a 10/10 HLA matched unrelated donor and a haploidentical donor. The hypothesis: Haploidentical stem cell transplantation with post cyclophosphamide induces a

myeloid leukemia
leukemia
cell transplantation
acute leukemia
cyclophosphamide
  • 1 views
  • 03 May, 2021
  • 24 locations
Haploidentical HCT for Severe Aplastic Anemia

This study is a prospective, single center phase II clinical trial in which patients with Severe Aplastic Anemia (SAA) or Telomere Biology Disorders (TBD) will receive a haploidentical transplantation. The purpose of this study is to learn more about newer methods of transplanting blood forming cells donated by a family …

fludarabine
cyclophosphamide
ejection fraction
red blood cell transfusion
glomerular filtration rate
  • 5 views
  • 04 Apr, 2021
  • 1 location
GVHD Prophylaxis With Methotrexate in Haploidentical HCT Using Posttransplant Cyclophosphamide

Allogeneic hematopoietic cell transplantation (HCT) is an important therapeutic strategy for many malignant and benign hematologic diseases. Haploidentical HCT has been increasingly used in

  • 0 views
  • 26 Jan, 2021
  • 2 locations
Risk Stratification Directed Conditioning Regimen for Haploidentical HSCT in SAA

The haplotype HSCT system including Bu(0.8mg/kg Q6hx2d)CTX(50mg/kgx4d)rATG(2.5mg/kgx4d) , established in Institute of Hematology of Peking University ,has been evaluated to be effective for acquired SAA.But some patients with high risk factors may not tolerate CTX 200mg/kg,alternative conditioning regimen including Bu/Fludarabine/dercreased CTX was studied in this trial.

fludarabine
cyclophosphamide
severe aplastic anemia
conditioning regimen
aplastic anemia
  • 0 views
  • 23 Jan, 2021
  • 1 location
Expanded Natural Killer Cells Following Haploidentical HSCT for AML/MDS

The study examines the application of expanded natural killer cells (NK cells) following haploidentical allogeneic hematopoietic stem cell transplantation (haplo-HSCT) for AML or MDS. Haplo-HSCT is a preferred treatment option for patients with AML or MDS without a HLA-matched donor. With administration of cyclophosphamide post-transplant , the safety of the …

aml/mds
cell transplantation
cyclophosphamide
  • 12 views
  • 27 Jan, 2021
  • 1 location
Haploidentical Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major

The purpose of the study is to assess the safety and efficacy of haploidentical hematopoietic stem cell transplantation for patients with thalassemia major.

stem cell transplantation
methotrexate
mycophenolate mofetil
fludarabine
cyclophosphamide
  • 21 views
  • 21 Jan, 2021
  • 1 location
Haploidentical Stem Cell Transplantation Using Post-Transplant Cyclophosphamide

Historically, the best results of allogeneic SCT have been obtained when the stem cell donor is a human leukocyte antigen (HLA)-matched sibling, however, this is only available for approximately 30 percent of patients in need for SCT. Alternative donor sources include matched unrelated donor utilizing the donor registry, cord blood …

blood transfusion
leukemia
cell transplantation
ejection fraction
lymphoid leukemia
  • 82 views
  • 29 Apr, 2021
  • 1 location