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Found 52 clinical trials
Virtual Cognitive Behavioural Therapy for Psychosis

Participants with schizophrenia-spectrum disorders who are experiencing active symptoms of psychosis will randomized to either receive 6 months of individual cognitive behavioural therapy for psychosis or to receive treatment as usual. Participants will be assessed at baseline, 6 months, and 12 months.

schizophrenia
psychosis
schizoaffective disorder
  • 0 views
  • 15 Mar, 2022
  • 1 location
K0706 for Patients Diagnosed With Dementia With Lewy Bodies

This study evaluates the safety and tolerability of treatment with K0706 in Dementia with Lewy Bodies (DLB). The hypothesis is that K0706 will be safe and tolerable and that this drug will alter CSF and plasma biomarkers in DLB. Clinical assessments of cognitive, behavioral and motor functioning will also be …

visual hallucinations
acetylcholinesterase
mental disorders
dementia
dopamine
  • 267 views
  • 13 Feb, 2022
  • 1 location
Implementation of Digital CBT for Insomnia in First Episode Psychosis

This study uses mixed methods to investigate the implementation of digital cognitive behavioural therapy for insomnia (Sleepio) in a first episode of psychosis service (FEP). Interviews will be conducted with keyworker clinicians and service users to consider their expectations for digital sleep intervention. The rates of recruitment into the study, …

behavior therapy
  • 0 views
  • 30 Sep, 2021
  • 2 locations
Nebulized Sub-dissociative Dose Ketamine at Three Different Dosing Regimens for Treating Acute Pain in the Pediatric ED

In the situation when intravenous access is not readily available or unobtainable, sub-dissociative dose ketamine can be administered via intranasal route (IN). The data supporting intranasal route in pediatric patients is somewhat conflicting with regards to the optimum intranasal dose (range 0.75-1 mg/kg) and frequencies of administration. Hence, another non-invasive …

acute pain
ketamine
analgesia
cancer
back pain
  • 24 views
  • 23 Apr, 2022
  • 1 location
Neuroscience of Charles Bonnet Syndrome

Charles Bonnet Syndrome (CBS) is a condition in which people experience complex visual hallucinations, such as 'Acrobats balancing on bicycles' or 'Spiders crossing meals'. The condition usually

  • 0 views
  • 28 May, 2022
  • 1 location
Impact of Closely Grouped, Iterative Exposures to Suxamethonium During ECT on the Sensitization to NMBA and the Development of Protective Antibodies (SismoSens)

Acute per-anesthetic hypersensitivity reaction (HSA-PA) is a rapidly occurring systemic reaction following injection of a drug during anesthesia (mortality between 3 and 9%). The substances responsible for these reactions in France are Neuro-Muscular Blocking Agents (NMBA) in 60% of cases. The main mechanism mentioned is an immediate systemic hypersensitivity immune …

electroconvulsive therapy
antidepressants
  • 0 views
  • 23 Apr, 2022
  • 1 location
Functional Relevance of Dopamine Receptors in Healthy Controls and Patients With Schizophrenia: Characterization Through [11C]NNC-112 and [18F]Fallypride Positron Emission Tomography

schizophrenia have difficulty thinking and experience hallucinations and delusions. Medications that change brain dopamine receptors can decrease these hallucinations and delusions. The cause of

Accepts healthy volunteers
delusions
dopamine
schizophrenia
hallucinations
  • 208 views
  • 22 Jul, 2022
  • 1 location
The PACE-DLB Study

of death within 6 months for individuals with DLB will include symptoms (e.g. worsening hallucinations, fluctuations) not captured in existing dementia end-of-life prediction tools. 2. To

dementia
depression
hallucinations
moderate dementia
  • 0 views
  • 25 Jan, 2022
  • 5 locations
Striatal Connectivity and Clinical Outcome in Psychosis

This is an observational neuroimaging treatment study. This study involves examining the neural circuitry of controlled treatment of patients presenting with a first-episode of psychosis with risperidone or aripiprazole. Patients who present for treatment of a first psychotic episode with a schizophrenia spectrum diagnosis and who are eligible to undergo …

scid
brief psychotic disorder
shared psychotic disorder
antipsychotics
mood disorder
  • 64 views
  • 25 Mar, 2022
  • 1 location
Determining the Pharmacogenetic Basis of Non-responsiveness to the Sedative Effects of Dexmedetomidine in Children

Intranasal Dexmedetomidine is one of the sedative drugs of choice commonly used as an anxiolytic premedication for children for diagnostic or therapeutic procedures. However, some children do not achieve the level of sedation expected with the usual dose after an expected timeframe, leading to distress and costly time wasted. In …

  • 0 views
  • 21 Mar, 2021
  • 1 location