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Found 52 clinical trials
Randomized Placebo Controlled Trial Evaluating the Efficacy of Pimavanserin, a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist, to Treat Impulse Control Disorders in Parkinson's Disease. (PIMPARK)

NUPLAZID® was approved in 2016 by the U.S. Food and Drug Administration (FDA) for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis. The link between

impulse control disorder
dopamine agonists
antidepressants
dyskinesia
hallucinations
  • 2 views
  • 25 Mar, 2022
  • 3 locations
Psychological Effects of Levodopa in Parkinson's Disease

The investigators aim is to study neuropsychiatric symptoms and underlying abnormalities in resting-state fMRI in patients with Parkinson's disease (PD) suffering from neuropsychiatric fluctuations, to enhance the understanding of the pathophysiological mechanisms underlying neuropsychiatric symptoms.

antiparkinsonian agents
levodopa
  • 0 views
  • 26 Mar, 2022
Effectiveness of Trauma Therapy in Patients With PTSD and Comorbid Psychotic Disorder

Effectiveness of trauma therapy using prolonged exposure for the treatment of post-traumatic stress disorder (PTSD) in patients with comorbid psychotic disorder

schizophrenia
scid
  • 0 views
  • 12 Jun, 2021
  • 1 location
Online Yoga and the Impact on Psychosis

Yoga and mindfulness are considered complementary and alternative healthcare options that involve breathing techniques, relaxation, and bodily postures (yoga only). Research has shown a positive effect of these on depression, quality of life, and other symptoms of psychosis. As an 8-week pilot study, the goal is to offer yoga and/or …

schizophrenia
Accepts healthy volunteers
depression
  • 0 views
  • 01 Jul, 2022
  • 1 location
Feasibility of a Novel Process-based Treatment for Patients With Psychosis

The purpose of this single-arm feasibility study is to develop and pilot test a novel process-based and modular group therapy approach for patients with acute psychotic symptoms in an inpatient setting.

psychotic symptoms
group therapy
delusions
hallucinations
psychosis
  • 0 views
  • 23 Jul, 2021
  • 1 location
To Assess the Efficacy and Safety of Ceftriaxone in Patients With Mild to Moderate Parkinson's Disease Dementia

This is a randomized, double blinded, placebo-controlled Phase II study to investigate the efficacy and safety of ceftriaxone in patients with mild to moderate Parkinson's disease dementia (PDD).This study will enroll approximately 106 patients to have up to 84 evaluable subjects, and conduct in Chung Shan Medical University Hospital, National …

  • 3 views
  • 21 Apr, 2022
  • 4 locations
Translumbosacral Neuromodulation for FI

Fecal Incontinence (FI) affects 40 million Americans, predominantly women and elderly. It is a major health care burden, significantly impairs quality of life and psychosocial function. FI is characterized by multifactorial dysfunction including lumbosacral neuropathy, anorectal sensori-motor dysfunction, and abnormal pelvic floor-brain innervation. A critical barrier to progress in the …

probe
neuromodulation
neuropathy
  • 85 views
  • 07 Aug, 2021
  • 2 locations
Examining a Digital Health Approach for Advancing Schizophrenia Illness Self-management and Provider Engagement

The effective treatment of schizophrenia is very challenging due to a number of factors. These include issues such as poor engagement with treatment plans and care providers, limited contacts with providers due to under-resourced health services, and the challenges inherent to schizophrenia symptoms. The outcomes of these problems include frequent, …

  • 0 views
  • 16 Feb, 2021
  • 1 location
Assessment of Transcranial Electrical Stimulation and Auditory Stimulation During Walking in Parkinson Patients

Parkinson's disease affects 1 in 100 people over the age of 60. Parkinson's disease (PD) is a progressive disease of the nervous system that affects movement, produced by the destruction of dopaminergic neurons found in a region of the brain called the basal ganglia Over time, different strategies have been …

brain stimulation
transcranial direct current stimulation
  • 0 views
  • 10 Mar, 2022
  • 1 location
Ketamine for Pain Control After Severe Traumatic Injury

This study evaluates if the early utilization of ketamine infusion therapy among acutely injured adult trauma hospital inpatients with an ISS >15 will decrease the amount of opioid pain medication used as compared with placebo group. Ketamine infusion therapy initiated within 12 hours of hospital arrival will lead to decreased …

oral morphine
pain relieving
morphine
opioid
ketamine
  • 28 views
  • 22 Dec, 2021
  • 1 location