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Found 57 clinical trials
Randomized Placebo Controlled Trial Evaluating the Efficacy of Pimavanserin a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist to Treat Impulse Control Disorders in Parkinson's Disease.

NUPLAZID was approved in 2016 by the U.S. Food and Drug Administration (FDA) for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis. The link between

hallucinations
depression
dyskinesia
levodopa
pramipexole
  • 1 views
  • 13 May, 2021
  • 29 locations
Effectiveness of Trauma Therapy in Patients With PTSD and Comorbid Psychotic Disorder

Effectiveness of trauma therapy using prolonged exposure for the treatment of post-traumatic stress disorder (PTSD) in patients with comorbid psychotic disorder

schizophrenia
scid
  • 0 views
  • 12 Jun, 2021
  • 1 location
Microglial Activation in Narcolepsy Type 1 and Kleine-Levin Syndrome: Positron Emission Tomography (PET) Study in [18F] DPA-714

Type 1 narcolepsy (NT1) is a chronic sleep disorder caused by the selective and irreversible loss of neurons from the hypothalamus, which synthesizes a neurotransmitter: hypocretin (Hcrt) / orexin. The exact cause of this destruction is still unknown, but the autoimmune hypothesis is strongly favored, involving the interaction of genetic …

  • 105 views
  • 25 Jan, 2021
  • 1 location
Feasibility of a Novel Process-based Treatment for Patients With Psychosis

The purpose of this single-arm feasibility study is to develop and pilot test a novel process-based and modular group therapy approach for patients with acute psychotic symptoms in an inpatient setting.

psychosis
hallucinations
psychotic symptoms
group therapy
delusions
  • 0 views
  • 23 Jul, 2021
  • 1 location
Translumbosacral Neuromodulation for FI

Fecal Incontinence (FI) affects 40 million Americans, predominantly women and elderly. It is a major health care burden, significantly impairs quality of life and psychosocial function. FI is characterized by multifactorial dysfunction including lumbosacral neuropathy, anorectal sensori-motor dysfunction, and abnormal pelvic floor-brain innervation. A critical barrier to progress in the …

neuropathy
probe
neuromodulation
  • 64 views
  • 07 Aug, 2021
  • 2 locations
To Assess the Efficacy and Safety of Ceftriaxone in Patients With Mild to Moderate Parkinson's Disease Dementia

This is a randomized, double blinded, placebo-controlled Phase II study to investigate the efficacy and safety of ceftriaxone in patients with mild to moderate Parkinson's disease dementia (PDD).This study will enroll approximately 106 patients to have up to 84 evaluable subjects, and conduct in Chung Shan Medical University Hospital, National …

  • 0 views
  • 30 Jul, 2021
  • 5 locations
Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Postoperative Analgesia

Scoliosis correction surgery is followed with severe pain. Patients after scoliosis correction surgery usually require high dose opioids and long duration analgesia, which may increase side effects and even drug tolerance. S-ketamine is the pure dextrorotatory enantiomer of ketamine with stronger analgesic effect and less side effects, but mental side …

  • 0 views
  • 25 Apr, 2021
  • 1 location
A Study of Tolerability and Efficacy of Cannabidiol on Motor Symptoms in Parkinson's Disease

The major purpose of this study is to assess the efficacy of CBD on motor symptoms of Parkinson's Disease (PD), and secondarily to study the safety and tolerability of CBD and other efficacy, particularly regarding tremor in PD. The study has been powered to detect a clinically significant reduction in …

motor symptoms
movement disorder
tremor
  • 1 views
  • 14 Jun, 2021
  • 1 location
K0706 for Patients Diagnosed With Dementia With Lewy Bodies

This study evaluates the safety and tolerability of treatment with K0706 in Dementia with Lewy Bodies (DLB). The hypothesis is that K0706 will be safe and tolerable and that this drug will alter CSF and plasma biomarkers in DLB. Clinical assessments of cognitive, behavioral and motor functioning will also be …

rigidity
behavioral disorder
visual hallucinations
bradykinesia
hallucinations
  • 79 views
  • 26 Aug, 2021
  • 1 location
Ketamine for Pain Control After Severe Traumatic Injury

This study evaluates if the early utilization of ketamine infusion therapy among acutely injured adult trauma hospital inpatients with an ISS >15 will decrease the amount of opioid pain medication used as compared with placebo group. Ketamine infusion therapy initiated within 12 hours of hospital arrival will lead to decreased …

  • 0 views
  • 24 Mar, 2021
  • 1 location