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Found 62 clinical trials
Accuracy of Pulse CO-Oximetry Technology in Characterizing Noninvasive SpHb

This protocol is a request from Masimo to assist in the collection of data to be used to further refine the accuracy of the monitor's algorithm.

elective surgery
  • 23 Mar, 2022
  • 1 location
Study of Erythrocyte Parameters and Hypercoagulability in Sickle Cell Disease (SCD-TGA) (SCD-TGA)

haemoglobin S (HbS) which polymerises in red blood cell (RBC) at deoxygenated state. SCD is associated with chronic haemolytic anaemia, vaso-occlusive crisis (VOC) leading to frequent hospitalisation.

Accepts healthy volunteers
vaso-occlusive crisis
sickle hemoglobin
  • 06 Jun, 2022
  • 1 location
Liver Toxicity in Lung Cancer Patients Treated With Immune-checkpoint Inhibitors.

Immune-checkpoint inhibitors have recently become available as a new therapy for a variety of cancers. This drugs function by boosting the anti-cancer immune response, but unfortunately, may cause off-target, non-specific immune activation, resulting in liver and gut toxicity. In order to understand the development of liver immune-related adverse events we …

advanced lung cancer
cancer chemotherapy
lung carcinoma
  • 22 Mar, 2022
  • 3 locations
Physical Performance Testing and Frailty in Prediction of Early Postoperative Course After Cardiac Surgery (Cardiostep)

Standard risk prediction models in cardiac surgery (such as EuroSCORE II or STS score) are designed to analyze solely the risk of short-term postoperative mortality. The postoperative morbidity, the ability to rehabilitate or the mid-term survival are not addressed by these means. Recently there have been some reports that addition …

bypass graft
  • 21 Mar, 2022
  • 1 location
Tolerance of Anti-Cancer Therapy in the Elderly (TOASTIE)

This is a multicentre observational study evaluating frailty and tolerance of chemotherapy in the elderly.

  • 10 Mar, 2022
Screening Patients With Diabetes Mellitus for the Presence of Skin Disorder of Scleredema

Scleredema is a scleroderma-like skin disorder appearing in 2.5-14% among patients with type 1 or 2 diabetes mellitus. This is a single centre study to screen consecutive patients with diabetes mellitus for the presence of scleredema,and to compare the clinical-laboratory data of patients with and without scleredema. Metabolic and vascular …

diabetes mellitus
  • 03 Mar, 2022
  • 1 location
ICIS in Burn Patients Compared to Other Inflammatory Markers

The current markers of inflammation that govern antibiotic treatment have their significant limitations, especially in patients with burns. According to previously published data, the newly proposed marker of infectious inflammation, the Intensive Care Infection Score (ICIS), appears to be a suitable diagnostic tool in distinguishing between inflammation of infectious and …

  • 10 Jun, 2021
  • 1 location
Mitochondrial DAMPs as Mechanistic Biomarkers of Mucosal Inflammation in Crohn's Disease and Ulcerative Colitis (MUSIC)

The MUSIC study is a multi-centre, longitudinal study set in the real world IBD clinical setting to investigate and develop a new biomarker approach that aims to inform both patients and clinicians of the current state of the affected gut lining (how inflamed or whether the bowel wall has completely …

crohn's disease
ulcerative colitis
  • 04 Jun, 2022
  • 1 location
Systemic Nitrosative/Oxidative Stress in Patients With Acute Brain Injury

Acute brain injury due to traumatic brain injury (TBI), intracerebral haemorrhage (ICH), and aneurysmal subarachnoid haemorrhage (SAH) carries a high morbidity and mortality, in part due to the development of secondary brain injury. The mechanisms behind secondary brain injury are incompletely understood, but oxidative/nitrosative stress and disturbances in the metabolism …

traumatic brain injury
acute brain injuries
  • 24 Oct, 2021
  • 1 location
Gut-Brain-axis: Targets for Improvement of Cognition in the Elderly (SmartAge)

Cognitive disorders increase with age and in the presence of metabolic diseases such as Type 2 Diabetes Mellitus (T2DM). In addition, digestive disorders, changes in dietary pattern and decreased activity negatively influence the microbiome. The hypothesis is that pharmacological intervention with metformin will modify the composition of the gut microbiota …

continuous glucose monitoring
type 2 diabetes mellitus
  • 04 Oct, 2022
  • 1 location