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Found 11 clinical trials
Antiretroviral Therapy for Acute and Chronic HIV Infection (AAHIV)

This is a protocol designed to randomize subjects with acute HIV infection to receive standard HAART or mega-HAART for subject who are enrolled in SEARCH 010 study (protocol title: Establish and

  • 23 Jan, 2022
  • 1 location
To Investigate the Efficacy and Safety of UB-421 Monotherapy in HIV-1 Infected Adults

The purpose of this phase III study is to evaluate the efficacy, safety and tolerability of UB-421 monotherapy in suppressing viral rebound in HIV-1 infected adults undergoing antiretroviral treatment interruption.

  • 26 May, 2022
  • 1 location
Electronic Cigarettes as a Harm Reduction Strategy Among People Living With HIV/AIDS

This is a research study to understand and determine the effectiveness of electronic cigarettes versus nicotine replacement therapy in adults who smoke and also live with HIV/AIDS in effort to reduce cigarette smoking.

nicotine product
nicotine patch
nicotine replacement
tobacco smoke
  • 23 Oct, 2022
  • 1 location
A Telemedicine and mHealth Intervention for Reducing Alcohol Consumption Among People Living With HIV/AIDS (TRAC)

While advances in medication have led to greatly improved outcomes for people living with HIV/AIDS, less than one-third of all people living with the disease are adherent enough to their medication to achieve viral suppression. Alcohol consumption has been shown to have a significant effect on HIV medication adherence, so …

HIV Vaccine
  • 18 Oct, 2022
  • 1 location
Anti-fungal Strategies in Acute-on-Chronic Liver Failure Patients

Early treatment of invasive fungal infections (IFI) may prevent undue mortality in acute on chronic liver failure (ACLF) patients. We aim to study the impact of early empiric treatment (based on clinical suspicion) of IFI as compared to pre-emptive treatment (based on biomarkers and culture positivity) on the outcomes in …

invasive fungal infections
abdominal perforation
  • 07 May, 2022
  • 1 location
A Phase 1 Trial of Pomalidomide in Combination With Liposomal Doxorubicin in Patients With Advanced or Refractory Kaposi Sarcoma

Background Kaposi sarcoma (KS) is a cancer most often seen in people with HIV. It causes lesions. These are usually on the skin but sometimes in the lymph nodes, lungs, and gastrointestinal tract. Researchers think a combination of drugs may help treat KS. Objective To test a combination of the …

progressive disease
cytotoxic chemotherapy
measurable disease
antiretroviral agents
  • 25 Oct, 2022
  • 1 location
Nivolumab and Ipilimumab in Treating Patients With HIV Associated Relapsed or Refractory Classical Hodgkin Lymphoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

This phase I trial studies the side effects and best dose of nivolumab when given with ipilimumab in treating patients with human immunodeficiency virus (HIV) associated classical Hodgkin lymphoma that has returned after a period of improvement or does not respond to treatment, or solid tumors that have spread to …

therapeutic agents
hiv viral load
  • 07 Oct, 2022
  • 23 locations
Leukapheresis Procedures to Obtain Plasma and Lymphocytes for Research Studies on Antiretroviral-Naive HIV-Infected Patients

treated with early highly active antiretroviral therapy (HAART). Leukapheresis is necessary to obtain enough cells to delineate the response of B cells to CD4+ T cell help, the CD8 factors associated with

hiv test
antiretroviral therapy
hiv antibodies
white blood cell count
  • 25 Oct, 2022
  • 1 location
An Evaluation of HIV-associated Neurocognitive Disorders (HAND) in Virologically Controlled Patients

Background People with human immunodeficiency virus (HIV) can sometimes develop thinking and memory problems. These problems can vary widely, from few symptoms to severe problems with memory and concentration. It initially was thought that good HIV treatment could prevent almost all HIV-related memory problems. However, even people with low HIV …

Accepts healthy volunteers
  • 21 Oct, 2022
  • 1 location
Outcomes of HIV Infected Individuals After Ten Years on Antiretroviral Treatment

Study Title: Outcomes of HIV infected individuals after ten years on antiretroviral treatment Short Title/Study ID: ALT cohort Protocol Version and Date: Version 1.0 June 2013 Clinical Phase: NA Methodology: Prospective observational study Study Duration: 01 January 2014- 30th June 2025 Study Centre(s): Single centre (Infectious Diseases Institute, Kampala, Uganda) …

antiretroviral agents
  • 21 Jan, 2021
  • 1 location