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Found 95 clinical trials
A Phase 3 Randomized, Open-label, Active-comparator Controlled Clinical Study of Pembrolizumab Versus Platinum Doublet Chemotherapy in Participants With Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma in the First-line Setting (KEYNOTE-C93/GOG-3064/ENGOT-en15)

The purpose of this study is to assess the safety and efficacy of treatment with pembrolizumab (MK-3475) compared to a combination of carboplatin and paclitaxel in women with mismatch repair deficient (dMMR) advanced or recurrent endometrial carcinoma who have not previously been treated with prior systemic chemotherapy. The primary study …

docetaxel
mk-3475
endometrial carcinoma
carboplatin
pembrolizumab
  • 0 views
  • 22 Oct, 2022
  • 121 locations
A Phase 3, Randomized, Double-Blind Study of Pembrolizumab Versus Placebo in Combination With Paclitaxel With or Without Bevacizumab for the Treatment of Platinum-resistant Recurrent Ovarian Cancer (KEYNOTE-B96/ENGOT-ov65)

The primary objective is to compare pembrolizumab plus paclitaxel with or without bevacizumab to placebo plus paclitaxel with or without bevacizumab, with respect to progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 as assessed by the investigator. The hypotheses are that pembrolizumab plus paclitaxel with or …

recurrent ovarian cancer
bevacizumab
cancer chemotherapy
hormone therapy
mk-3475
  • 1 views
  • 24 Oct, 2022
  • 154 locations
Improving Sleep in Gynecologic Cancer Survivors

This purpose of this study is to learn about how to provide treatment to gynecologic cancer survivors who have difficulty sleeping.

sleep problem
cancer
poor sleep
  • 0 views
  • 05 Jun, 2022
  • 2 locations
Home-Based Telemonitoring Program for Functional Recovery and Symptoms in Gastrointestinal, Genitourinary, or Gynecologic Cancer Patients Undergoing Abdominal Surgery

days after surgery in patients with gastrointestinal, genitourinary, or gynecologic cancer who are scheduled to undergo abdominal surgery. Patients may experience a decrease in functional capacity and

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 3 locations
Liposomal Bupivacaine With or Without Hydromorphone for the Improvement of Pain Control After Laparotomy in Patients With Gynecological Malignancies

This phase IV trial studies how well liposomal bupivacaine with or without hydromorphone works in improving pain control during the first 24 hours after surgery in patients with gynecological malignancies undergoing laparotomy. Liposomal bupivacaine is routinely infiltrated into the skin surrounding the abdominal incision, and is effective in providing good …

cancer
laparotomy
  • 0 views
  • 04 Oct, 2022
  • 1 location
Physiotherapy Treatment for Gynecological Cancer Survivors With Urinary Incontinence

The aims of this pilot study are to examine the feasibility and to explore the effects of a physiotherapy treatment compared to standard usual care in gynecological cancer survivors with urinary incontinence in preparation of a large randomized controlled study.

cancer
urinary incontinence
mixed incontinence
  • 3 views
  • 26 Mar, 2022
  • 1 location
Gyn Onc Prehab Study

Patients will be randomized to a unimodal or trimodal prehabilitation program prior to surgery for known or suspected gynecologic cancer.

Accepts healthy volunteers
cancer
prehabilitation
gynecologic cancer
  • 15 views
  • 02 May, 2022
  • 1 location
Prehabilitation Plus ERAS Versus ERAS in Gynecologic Oncology: a Randomized Clinical Trial

Prospective, interventionist, controlled and randomized study to test the effectiveness of a multimodal prehabilitation protocol in patients who will undergo gynecological surgery.

  • 0 views
  • 25 Jul, 2021
  • 1 location
Pelvic Physical Therapy for Sexual Dysfunction in Gynecologic Oncology Survivors

The purpose of this research study is to investigate the use of pelvic physical therapy for gynecologic cancer survivors who report sexual dysfunction. Physical therapy experts believe that a

  • 0 views
  • 06 May, 2022
  • 1 location
A Phase II Trial of Pembrolizumab and Lenvatinib in Patients With Recurrent or Persistent Clear Cell Carcinoma of the Ovary

This research study is being done to test the efficacy and safety of combining the study drugs pembrolizumab and lenvatinib in patients with clear cell ovarian cancer. The names of the study drugs involved in this study are: Lenvatinib Pembrolizumab

  • 0 views
  • 27 Oct, 2022
  • 1 location