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Found 11 clinical trials
A Trial of Guanfacine-er for Cannabis Use Disorder

The primary purpose of this study is to investigate the effect of guanfacine-ER on reductions in cannabis use and explore its effects on impulsivity and withdrawal through a hybrid in-person and

  • 0 views
  • 16 Jun, 2022
  • 1 location
The Effect of Guanfacine on Delirium in Critically Ill Patients

, current therapy is focused on non-pharmacologic prevention techniques and pharmacologic agents are used once delirium is established. Guanfacine, an alpha-2 agonist, has been identified as a potential

  • 17 views
  • 26 Nov, 2021
  • 1 location
Efficacy of Guanfacine and Lidocaine Combination in Trigeminal Nerve Block for Pain Management in Trigeminal Neuropathy

A phenome-wide association study (PheWAS) identified an association between a loss of function variant in the human alpha 2B adrenergic receptor gene and trigeminal nerve disorders. Guanfacine

facial pain
deficit
ache
nerve block
hypertension
  • 477 views
  • 12 Mar, 2022
  • 1 location
Noradrenergic Add-on Therapy With Guanfacine (NorAD)

NorAD is a clinical trial funded by the UK National Institute of Health Research. In this trial the investigators will assess whether a long-acting preparation of guanfacine, a drug used to

rivastigmine
donepezil
galantamine
mini-mental state examination
cognitive assessment
  • 9 views
  • 15 Jul, 2022
  • 1 location
Combining Varenicline and Guanfacine for Smoking Cessation

The novel design of this study combines a laboratory paradigm to evaluate stress-induced smoking behavior and smoking-related reinforcement, followed by a 12-week treatment phase to evaluate clinical outcomes.

treatment regimen
carbon monoxide
Accepts healthy volunteers
varenicline
a 12
  • 68 views
  • 24 Mar, 2022
  • 1 location
Guanfacine to Improve Substance Use Outcomes in Women

Hypothesis: Guanfacine (GUA) (3mg/day) will reduce drug craving, improve cognitive flexibility and result in associated lower drug use in women with substance use disorder (SUD) in an outpatient

opioid use
substance use
drug use
opioid
substance use disorder
  • 68 views
  • 04 Oct, 2022
  • 1 location
Maximizing trEatment of Neurological Dysfunction Using INtravenous Guanfacine Study (MENDING)

This proof-of-concept study examines whether the acute brain dysfunction that occurs in critically ill patients is improved by administration of intravenous guanfacine.

  • 22 views
  • 22 Mar, 2022
  • 1 location
The Effect of Guanfacine Extended-release on Attention Deficit Hyperactivity Disorder (ADHD)-Associated Insomnia

This study seeks to determine, using special sleep tests (polysomnography and actigraphy) if guanfacine extended release is able to improve nighttime sleep in children with ADHD

initial insomnia
actigraphy
insomnia
polysomnography
  • 459 views
  • 08 Nov, 2020
  • 1 location
Mechanistic Evaluation of Guanfacine on Drinking Behavior in Women and Men With Alcohol Use Disorders

For this protocol, the investigators plan to collect pilot data to examine sex differences in guanfacine's effect on 1) counteracting stress and stimulation based drinking behavior in the laboratory and 2) improving clinical outcomes during a subsequent treatment phase.

Accepts healthy volunteers
  • 2 views
  • 17 Mar, 2022
  • 1 location
Treatment With Cannabis Oil Containing CBD, THC, CBDV or CBG vs. Placebo of Persons With ADHD

: stimulants (such as methylphenidate and amphetamines) and non-stimulants (such as atomoxetine, guanfacine and clonidine) but some persons cannot tolerate their secondary effects or find them non-effective

  • 0 views
  • 04 Oct, 2022
  • 1 location