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Found 95 clinical trials
Scottish Advanced Fetal Research Study (SAFeR)

In-utero exposure to drugs and chemicals through maternal smoking, alcohol use, drug abuse, prescription medicines and occupational/lifestyle exposures is widespread. Such exposures can alter fetal development and programming, leading to the effects becoming "locked in" from birth and causing long-term adverse consequences for the individual. These include costly and widespread …

Accepts healthy volunteers
  • 25 May, 2022
  • 1 location
MiMBa Pregnancy Registry

The MiMBa (Malaria in Mothers and Babies) Pregnancy Registry aims to generate robust evidence on the safety of a range of antimalarials when used in pregnancy, particularly in the first trimester. This will be a multi-country observational study and will be deployed in several field sites in Africa.

  • 09 Apr, 2021
  • 1 location
Brain Development Research Program

Dr. Elliott Sherr and his collaborators at University of California, San Francisco (UCSF) are studying the genetic causes of disorders of cognition and epilepsy, in particular disorders of brain development that affect the corpus callosum, such as Aicardi syndrome, as well as two additional brain malformations, polymicrogyria and Dandy-Walker malformation. …

  • 04 Oct, 2022
  • 1 location
Whole Genome Medical Sequencing for Gene Discovery

Background A number of rare inherited diseases affect only a few patients, and the genetic causes of these conditions remain unknown. Researchers are studying the use of a new technology called whole genome sequencing to learn which gene or genes cause these conditions. Understanding the genes that cause these diseases …

genetic test
genetic testing
genetic analysis
skin biopsy
  • 18 Oct, 2022
  • 1 location
An Investigation of Pituitary Tumors and Related Hypothalmic Disorders

There is a variety of tumors affecting the pituitary gland in childhood; some of these tumors (eg craniopharyngioma) are included among the most common central nervous system tumors in childhood. The gene(s) involved in the pathogenesis of these tumors are largely not known; their possible association with other developmental defects …

linkage analysis
Accepts healthy volunteers
central nervous system tumors
  • 20 Sep, 2023
  • 1 location
MRI Study of Musculoskeletal Function

This study will use magnetic resonance imaging (MRI) and ultrasound images to study how muscles, tendons, and bones work together to cause motion. The procedure is one of several tools being developed to characterize normal and impaired musculoskeletal function, with the goal of developing improved methods of diagnosis and treatment …

serious injury
movement disorders
Accepts healthy volunteers
mri study
  • 08 Apr, 2023
  • 1 location
Genomic Sequencing and Personalized Treatment for Birth Defects in Neonatal Intensive Care Units

The purpose of study is to evaluate the benefits of using the Next Generation Sequencing Technology to diagnose birth defects and genetic diseases. The results from genomic sequencing can also significantly shorten the time of examination, improve the diagnosis rate, guide the clinical treatments. So the ultimate goal is individualized …

genetic disorder
genetic testing
  • 09 Apr, 2023
  • 1 location
Evaluation of Children With Endocrine and Metabolic-Related Conditions

diagnose or treat their condition. These could include: Blood, urine, and saliva tests Growth hormone test Pituitary and adrenal function tests Picture of chromosomes

endocrine disorder
growth hormone
genetic tests
  • 20 Sep, 2023
  • 1 location
Diagnosis and Management of Intrauterine Growth Restriction and Congenital Anomalies

The purpose of this prospective cohort study is to build a large platform that includes clinical information (prenatal diagnosis and postnatal follow-up data) and biological specimen banks of fetuses/infants with IUGR or congenital anomalies, which provide vital support and research foundation for accurate diagnosis, precision treatment and meticulous management.

intrauterine growth retardation
  • 09 Feb, 2022
  • 1 location
Mayo AVC Registry and Biobank

Arrhythmogenic ventricular cardiomyopathy (AVC) is a genetic condition which affects the heart and can lead to heart failure and rhythm problems, of which, sudden cardiac arrest or death is the most tragic and dangerous. Diagnosis and screening of blood-relatives is very difficult as the disease process can be subtle, but …

exercise tests
cardiac death
genetic condition
stress test
  • 11 May, 2022
  • 2 locations