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Found 21 clinical trials
NETs: Protection or Harm in Neonatal Inflammation or Infection

This is a prospective in vitro cell biology study of polymorphonuclear leukocyte (PMN) protein synthesis in response to PAF. PMNs from cord blood of premature human infants at risk for NEC (birth weight between 501 - 1500 grams) and PMNs from cord blood of healthy term infants will be isolated …

Accepts healthy volunteers
  • 21 Apr, 2022
  • 1 location
NIH Participation to USIDNET Registry

Background People with primary immune deficiency diseases (PIDD) have weak immune systems. This makes it hard for their bodies to fight infection. The Immune Deficiency Foundation has a network to collect data about people with PIDD. It is called the United States Immunodeficiency Network. It will help doctors and scientists …

primary immunodeficiency
  • 28 Oct, 2022
  • 1 location
Recruitment and Apheresis Collection of Peripheral Blood Hematopoietic Stem Cells, Mononuclear Cells and Granulocytes

The research goal of this study is to obtain CD34+ hematopoietic stem cells (HSC) from peripheral blood and/or bone marrow, and Mononuclear Cells (lymphocytes and monocytes), and granulocytes (grans) from peripheral blood that will be used in the laboratory and/or in the clinic to develop new cell therapies for patients …

bone marrow procedure
gene therapy
platelet count
immune disorder
blood test
  • 20 Oct, 2022
  • 1 location
Research Respiratory Tract Procedures

This study will collect fluid and tissue specimens from the lungs and nose of healthy people and people with a history of lung infections. The specimens will be examined for differences between the two groups that may be associated with susceptibility to certain infections. Healthy normal volunteers and people with …

hepatitis serologies
lung diseases
pulse oximetry
chest x-ray
  • 21 Oct, 2022
  • 1 location
Evaluation of Patients With Immune Function Abnormalities

severe combined immunodeficiency (XSCID), chronic granulomatous disease (CGD), and leukocyte adhesion deficiency (LAD), or conditions resulting from outside factors, such as graft-versus-host disease

Accepts healthy volunteers
  • 07 Oct, 2022
  • 1 location
Detection and Characterization of Infections and Infection Susceptibility

This screening study will examine the causes of immune disorders affecting white blood cells, which defend against infections and will try to develop better means of diagnosis and treatment of these immune disorders. This is a 2 visit screening study and patients determined to be of interest for additional study …

  • 07 Oct, 2022
  • 1 location
A Natural History Study of the Immune Regulation of Idiopathic Inflammatory Bowel Diseases: Crohn's Disease, Ulcerative Colitis, and Other Inflammatory Conditions of the Gut

This study will investigate in patients with Crohn s disease and ulcerative colitis how the body s immune system controls inflammation in the gastrointestinal tract (stomach and intestines)-specifically, how lymphocytes (a type of white blood cell) function in inflammatory responses. This protocol does not involve any experimental treatments. Patients between …

platelet count
immunosuppressive agents
intestinal diseases
  • 20 Oct, 2022
  • 1 location
Studies of Disorders With Increased Susceptibility to Fungal Infections

Background Researchers are interested in studying disorders that make individuals more susceptible to fungal infections, specifically infections with the Candida yeast. These disorders are often related to problems with the immune system and may have genetic factors, which suggests that researchers should study not only the individual with the disorder, …

myeloperoxidase deficiency
immune globulin
  • 23 Oct, 2022
  • 1 location
Exploring Pathogenesis and Treatment of Hypercalcemia Caused by Intramuscular Injection of Paraffinoil

The aim of the study is to characterize paraffin oil induced granulomatous disease. We will investigate pathogenesis and natural history of paraffin disease. Subsequently, through further

treatment of hypercalcemia
  • 26 Feb, 2022
  • 1 location
ACE and HLA Genotypes Predict Severity and Disease Progression in Danish Sarcoid Patients

Sarcoidosis is a multisystem granulomatous disease of unknown cause histologically characterized by noncaseating granulomas. Genetic factors affect disease course, which is highly variable and

granulomatous disease
  • 06 Oct, 2021
  • 1 location