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Found 30 clinical trials
Evaluate the Remission MAINtenance Using Extended Administration of Prednisone in Systemic Anti-neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis.

Immunosuppressive therapy of granulomatosis with polyangiitis (GPA, Wegener's) and microscopic polyangiitis (MPA) has transformed the outcome from death to a strong likelihood of disease control

  • 0 views
  • 23 Jan, 2021
  • 58 locations
Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS)

percent of scleritis cases are associated with systemic autoimmune conditions including rheumatoid arthritis and granulomatosis with polyangiitis. Infectious causes including herpes virus and varicella

  • 0 views
  • 24 Jan, 2021
  • 1 location
Analgesic Effect of rTMS in Vasculitic Neuropathy

Vasculitic neuropathy (VN) results from inflammation and destruction of the walls of predominantly small vessels with subsequent ischemic damage of peripheral nerves. VN is painful in vast majority of patients and the pain is intractable with pharmacotherapy in about 40% of cases. Repetitive Transcranial Magnetic Stimulation (rTMS) is a noninvasive …

  • 0 views
  • 28 Jan, 2021
  • 1 location
Ductal Lavage Versus Corticosteroids Therapy for Idiopathic Granulomatous Mastitis

A single-arm, proof-of-concept trial has shown the safety and efficacy of ductal lavage as a treatment for idiopathic granulomatous mastitis patients (Manuscript accepted in Journal of Surgical Research 2018). In this multicenter, randomized, open-labeled, non-inferior trial, the investigators are going to enroll eligible granulomatous mastitis patients and randomized them into …

  • 0 views
  • 23 Jan, 2021
  • 4 locations
Nasal Septum Perforation Treatment Using Tissue Engineered Cartilage Graft

The purpose of this study is to investigate the safety and feasibility of implanting an engineered cartilage tissue in an interposition graft with a temporoparietal fascia (TPF) flap to repair medium size septal perforation. The engineered cartilage graft is obtained by culturing expanded autologous nasal chondrocytes within a collagen type …

  • 0 views
  • 15 May, 2021
  • 1 location
A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis

ATLAS study is a clinical trial to evaluate the potential role of subcutaneous adrenocorticotropic hormone (ACTH) gel in the management of non-infectious scleritis. Specifically, the ATLAS Study aims to evaluate the safety, tolerability and effect of 2 different dose regimens of ACTH gel administered by subcutaneous (SC) injection in patients …

  • 1 views
  • 16 Aug, 2021
  • 5 locations
Dupilumab for Prevention of Recurrence of CRSwNP After ESS

The investigators believe that administering Dupilumab during the pre- and peri-operative period of surgery for chronic rhinosinusitis with nasal polyps (CRSwNP) will safely downregulate Type 2 inflammation of the healing sinus environment and will allow for better coordinated and more effective mucosal healing. Specifically, the investigators believe that endoscopic signs …

  • 0 views
  • 13 Jun, 2021
  • 1 location
Abatacept for the Treatment of Relapsing Non-Severe Granulomatosis With Polyangiitis (Wegener's)

granulomatosis with polyangiitis (Wegener's) (GPA) . Participants will be randomized 1:1 to receive either abatacept 125 mg or placebo administered by subcutaneous injection once a week. Participants will

anti-neutrophil cytoplasmic antibody
remission
chest radiograph
granulomatous inflammation
churg-strauss syndrome
  • 197 views
  • 28 Apr, 2021
  • 26 locations
Treatment and Natural History Study of Lymphomatoid Granulomatosis

This study will evaluate the response and long-term effects of alpha-interferon in patients with lymphomatoid granulomatosis (LYG). The disease causes proliferation of destructive cells

gm-csf
doxorubicin
bone marrow procedure
filgrastim
prednisone
  • 16 views
  • 12 Sep, 2021
  • 1 location
Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis.

relapsing or newly-diagnosed Eosinophilic granulomatosis with polyangiitis EPGA receiving standard of care therapy including glucocorticoid therapy reduction/withdrawal.

immunosuppressive agents
granulomatosis
remission
prednisone
azathioprine
  • 0 views
  • 26 May, 2021
  • 1 location