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Found 66 clinical trials
Autologous Gene Therapy for Artemis-Deficient SCID

This study aims to determine if a new method can be used to treat Artemis-deficient Severe Combined Immunodeficiency (ART-SCID), a severe form of primary immunodeficiency caused by mutations in the DCLRE1C gene. This method involves transferring a normal copy of the DCLRE1C gene into stem cells of an affected patient. …

bone marrow procedure
busulfan
cell transplantation
stem cell transplantation
tetanus
  • 0 views
  • 10 Mar, 2022
  • 1 location
Cyclin D1 Based TPF(Docetaxel, Cisplatin and 5-fluorouracil) Induction Chemotherapy for OSCC(Oral Squamous Cell Carcinoma) Patients at cN2(Clinical Node 2) Stage: a Phase II Randomized Controlled Trial

The purpose of this study is to To confirm the predictive value of CCND1 for TPF induction in cN2 patients with OSCC

ccnd1
induction chemotherapy
chemotherapy regimen
carcinoma of oral cavity
external radiation
  • 19 views
  • 20 Oct, 2022
  • 1 location
A Randomized Phase II Trial of TPF Induction Chemotherapy in cN2 Patients With Oral Squamous Cell Carcinoma

To confirm the subgroup result from TPF (docetaxel, cisplatin and 5-fluorouracil ) trial (NCT01542931) that cN2 OSCC patients could benefit from TPF induction chemotherapy compared to the standard treatment.

5-fluorouracil
induction chemotherapy
chemotherapy regimen
carcinoma of oral cavity
external radiation
  • 0 views
  • 20 Oct, 2022
  • 1 location
GDF15 (Growth Differentiation Factor 15) Based TPF Induction Chemotherapy for Oral Squamous Cell Carcinoma Patients at T3/T4cN0M0 Stage: a Phase II Randomized Controlled Trial

The purpose of this study is to confirm the predictive value of GDF15 expression for TPF induction in T3/T4cN0M0 patients with OSCC

induction chemotherapy
chemotherapy regimen
carcinoma of oral cavity
external radiation
renal function
  • 18 views
  • 28 Oct, 2022
  • 1 location
A Randomized Phase II Trial of Low Stathmin Expression as a Predictive Biomarker for OSCC Patients Receiving TPF Induction Chemotherapy Followed by Radical Surgery and Radiotherapy/Chemoradiotherapy

To investigate the predictive value of stathmin expression as a predictive biomarker in OSCC patients, who treated with TPF (docetaxel, cisplatin and 5-fluorouracil ) induction chemotherapy followed by radical surgery and radiotherapy/chemoradiotherapy.

concurrent chemotherapy
fluorouracil
induction chemotherapy
chemoradiotherapy
carcinoma
  • 1 views
  • 29 Oct, 2022
  • 1 location
Reduced Intensity BMT for Immune Dysregulatory and Bone Marrow Failure Syndromes Using Post-Transplant Cyclophosphamide

This is a Phase II prospective trial to assess the rates of donor engraftment using reduced intensity conditioning (RIC) hematopoietic stem cell transplant (HSCT) and post-transplant cyclophosphamide (PTCy) for patients with primary immune deficiencies (PID), immune dysregulatory syndromes (IDS), and inherited bone marrow failure syndromes (IBMFS).

wiskott-aldrich syndrome
hla-a
ipex
immunodeficiency
immunoglobulin e
  • 3 views
  • 24 Feb, 2022
  • 1 location
Prospective Cohort Study of Children With GSD1b Receiving Empagliflozin

This is a prospective cohort study of children with GSD1b to evaluate their outcome after using empagliflozin for neutrophil defects.

  • 0 views
  • 22 Aug, 2021
  • 1 location
Evaluation of New Biomarker-based Approaches for Improving the Diagnosis of Childhood Tuberculous Meningitis (TBMBIOMARKER)

The rapid diagnosis of tuberculosis (TB) in children remains a serious challenge owing to limitations in the existing diagnostic tests. TB meningitis (TBM), an extrapulmonary form of TB, is the most severe manifestation of paediatric TB. TBM results in high morbidity and mortality in children, despite the availability of chemotherapy, …

  • 0 views
  • 03 Jun, 2022
  • 1 location
Recruitment and Apheresis Collection of Peripheral Blood Hematopoietic Stem Cells, Mononuclear Cells and Granulocytes

The research goal of this study is to obtain CD34+ hematopoietic stem cells (HSC) from peripheral blood and/or bone marrow, and Mononuclear Cells (lymphocytes and monocytes), and granulocytes (grans) from peripheral blood that will be used in the laboratory and/or in the clinic to develop new cell therapies for patients …

blood test
Accepts healthy volunteers
filgrastim
immune disorder
deficiency
  • 39 views
  • 20 Oct, 2022
  • 1 location
Intrauterine Infusion of GCSF and Reproductive Outcomes in Infertile Women With History of RIF

Intrauterine infusion of granulocyte colony stimulating factor and reproductive outcomes in infertile women with history of recurrent implantation failure

transvaginal ultrasound
cavities
hysteroscopy
cytokines
  • 0 views
  • 03 Jul, 2022
  • 1 location