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Found 353 clinical trials
Physiotherapy and Therapeutic Exercise Program in Graft-versus-host Disease (GvHD)

Range of motion, antropometric measurements, quality of life questionnaire and 2 minutes walk test will be implemented as an initial assessment. Physical exercise program will take 2 sessions a week for six months, and several follow-ups: before, during and after treatment.

  • 0 views
  • 14 Jun, 2022
  • 1 location
Ibrutinib and Rituxan for Chronic GVHD

This is a phase II trial evaluating the safety and efficacy of the combination of Ibrutinib and Rituximab as primary treatment of chronic GVHD. We plan to enroll 35 patients on this study

chronic graft versus host disease
immunosuppressive agents
immunosuppression
rituximab
corticosteroids
  • 12 views
  • 26 Apr, 2022
  • 1 location
Haplo Peripheral Blood Sct In GVHD Prevention

This research study is studying the RGI-2001 for preventing Graft-vs-Host Disease (GVHD) in people with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), myelodysplastic syndrome

cancer
graft versus host disease
mycophenolate mofetil
sirolimus
gilbert's syndrome
  • 0 views
  • 10 Oct, 2021
Pediatric GVHD Low Risk Steroid Taper Trial

The standard treatment for acute graft-vs-host disease (GVHD) is to suppress the activity of the donor immune cells using steroid medications such as prednisone. Although most GVHD, especially

  • 0 views
  • 07 Oct, 2022
  • 1 location
First Line Therapy for High Risk Acute GVHD

The purpose of this study is to determine the efficacy and safety of combined Ruxolitinib With Corticosteroids as First Line Therapy for the Treatment of High risk aGVHD(acute graft-versus-host

cancer
graft versus host disease
hematologic disorders
cell transplantation
hematologic malignancy
  • 0 views
  • 09 Jun, 2022
  • 1 location
Neihulizumab (ALTB-168) in Patients With Steroid-refractory Acute Graft-versus-host Disease or Treatment-refractory Acute Graft-versus-host Disease

A Phase I study to establish the pharmacokinetics, pharmacodynamics, safety and efficacy profiles of Neihulizumab in patients with steroid-refractory or treatment refractory acute graft-versus

  • 32 views
  • 04 Oct, 2022
  • 1 location
Leflunomide for Musculoskeletal GVHD After Allogeneic Stem Cell Transplant

Graft versus host disease (GVHD) is a well-known complication of allogeneic transplant. In GVHD, the cells of the donor attack the patient's tissues and cause damage. It can affect any organ or

  • 0 views
  • 28 Jun, 2021
  • 1 location
Novel BET Inhibitor PLX51107 for Steroid-Refractory Acute GVHD

This phase Ib/II trial studies the side effects of PLX51107 in treating steroid-refractory acute graft versus host disease (GVHD). PLX51107 is a novel, potent non-benzodiazepine structured small

  • 0 views
  • 23 Apr, 2022
  • 1 location
To Compare the Efficacy of the Addition of Methotrexate (MTX) to Current Standard Acute Graft-versus-host Disease (GVHD) First-line Treatment With Corticosteroids (MTX-aGVHD)

of a composite endpoint of graft-versus-host disease-free and corticosteroids-free survival at 12 months after randomization

graft versus host disease
steroid therapy
hematologic disorders
platelet count
corticosteroid therapy
  • 0 views
  • 07 Oct, 2022
  • 1 location
Detection of Graft Versus Host Disease With [18F]F-AraG

This is a single-center imaging study to determine utility of in vivo imaging with [18F]F-AraG to identify sites of Graft Versus Host Disease (GVHD) in patients highly suspected of having acute

corticosteroid therapy
steroid therapy
acute graft-versus-host disease
Accepts healthy volunteers
  • 14 views
  • 03 Mar, 2022
  • 1 location