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Found 83 clinical trials
Semitendinosus Graft as Meniscal Transplant

Removal of meniscal tissue is described to result in poor knee function and a significant risk for future development of osteoarthritis. Different implants have been suggested to substitute a removed meniscus. Meniscal allograft transplantation is not widely available due to costs and availability. The semitendinosus tendon is a known graft …

  • 22 Feb, 2021
  • 1 location
Highly Suppressive Treg in Delayed and Slow Graft Function After Kidney Transplantation

risk of acute rejection and graft failure. There are currently no clinically accepted biomarkers and no specific treatments for delayed/slow graft function. Regulatory T cells are protective in

kidney transplant
graft failure
  • 09 May, 2022
  • 1 location
HEARTBiT: Multi-Marker Blood Test for Acute Cardiac Transplant Rejection (HEARTBiT)

Heart transplantation is a life saving therapy for people with end stage heart failure. Acute rejection, a process where the immune system recognizes the transplanted heart as foreign and mounts a response against it, remains a clinical problem despite improvements in immunosuppressive drugs. Acute rejection occurs in 20-30% of patients …

heart failure
blood test
Accepts healthy volunteers
heart transplantation
  • 10 Feb, 2022
  • 4 locations
Social & Contextual Impact on Children Undergoing Liver Transplantation

The social determinants of health have a large impact on health. For example, neighborhood socioeconomic deprivation is associated with increased risk of medication non-adherence, graft failure

liver transplant
  • 12 Sep, 2021
  • 10 locations
Indications for Osteochondral Allograft Transplantation

performed. We will document all adverse events and complications, including joint or incision infection, graft failure, hardware failure, and arthrofibrosis. Patients with a VAS pain score >5 beyond 3

range of motion
based products
  • 02 Feb, 2022
  • 1 location
Optimization of Donor-Recipient Matching in Lung Transplantation (ADRTP)

among 260 transplant centers. Between 2010 and June 2017, the 3-month survival rate of patients after lung transplantation is 90%. The causes of early death are primary graft failure, renal failure

  • 27 Apr, 2022
  • 1 location
Predicting Endoleaks Following Endovascular Aortic Aneurysm Repair Using 18F-Sodium Fluoride (PET-EVAR)

The purpose of the study is to describe Sodium Fluoride uptake (using Positron Emission Tomography-Computed Tomography - PET-CT) following Endovascular Aneurysm Repair (EVAR) and to determine whether Sodium Fluoride PET-CT can predict the development of endoleaks.

  • 23 May, 2022
  • 4 locations
Study of Stem Cell Transplant vs. Non-Transplant Therapies in High-Risk Myelofibrosis

The purpose of this research study is to see how effective hematopoietic stem cell transplantation (HCT) is compared to best available non-transplant therapies (BAT) in patients with high risk myelofibrosis. This will be done by asking participants to choose the treatment that they prefer to receive (HCT or BAT) and …

stem cell transplantation
essential thrombocythemia
  • 24 Feb, 2021
  • 6 locations
The Role of Hepcidin as a Biomarker to Predict Successful Renal Transplantation

High hepcidin concentrations indicate that iron is blocked from secretion from the reservoir. Hepcidin may be useful in prediction functional iron utilization in renal failure patients. Hepcidin is also associated with chronic renal failure and residual renal function in dialysis patients. Recent studies have shown that hepcidin is a potential …

  • 26 Jan, 2021
  • 1 location
Target Busulfan Exposure in Children With HSCT in China

Objectives To evaluate the correlation between BU exposure and post-transplant clinical results (efficacy and safety) to establish the optimal BU treatment window for myeloablative conditioning in Chinese pediatrics, provide theoretical basis and the new strategy for BU individualized dosage, further optimize transplant treatment and reduce drug-related toxicity. Population 500 participants …

  • 19 Mar, 2021
  • 1 location