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Found 84 clinical trials
Tocilizumab for the Prevention of Graft Failure and GVHD in Haplo-Cord Transplantation

tocilizumab, an IL-6 receptor monoclonal antibody, to improve immune reconstitution and reduce relapse while preserving low rates of graft failure and graft versus host disease (GVHD).

chronic lymphocytic leukemia
graft versus host disease
lymphoma
transplant conditioning
ejection fraction
  • 3 views
  • 06 Nov, 2021
  • 1 location
T-lymphocytes CD8+/HLA-DR+ and Acute Rejection After Lung Transplantation

The objectives of the study is to identify associations between acute rejection and the increase of T (CD4/CD8) and B circulating lymphocytes expressing specific markers of activation and differentiation (HLA-DR, CD25, CD38, CD45RO, CCR7). 110 adults over 18 years, on national waiting list for a first lung transplantation in the …

  • 0 views
  • 03 Nov, 2021
  • 1 location
Sirolimus Use in Angioplasty for Vascular Access Extension (SAVE)

Dialysis patients presenting for angioplasty intervention for graft failure will be randomized to receive either Sirolimus or not receive Sirolimus (standard of care) to assess the time from

platelet count
dialysis
sirolimus
  • 42 views
  • 30 Jan, 2022
  • 1 location
Benadamustine Fludarabine and Busulfan Conditioning in Recipients of Haploidentical Stem Cell Transplantation (FluBuBe)

whether addition of bendamustine to fladarabine and busulfan conditioning reduces the risk of primary graft failure after haploidentical allograft.

tacrolimus
busulfan
myeloablative conditioning
fludarabine
mycophenolate mofetil
  • 0 views
  • 05 Jul, 2021
  • 1 location
Evaluation of the Safety of Use of Anti-IL6 Receptor Antibodies to Reduce Allo-sensitization Post Allograft Nephrectomy (RAIPONS)

Graft nephrectomy is associated with massive allo-sensitization following this event. The occurrence of anti-HLA antibodies is a major barrier to perform a second kidney transplantation. Investigators propose here to evaluate in a phase II pilot study, the safety of the use of a single dose of Tocilizumab immediately before or …

metastases
  • 0 views
  • 24 Apr, 2022
  • 1 location
Tumescence in HNC Skin Graft Reconstruction

Our primary objective is to determine if the use of tumescence has a meaningful effect on STSG uptake at the recipient site. This is an important outcome because poor graft uptake results in the need for prolonged local wound care, additional clinic visits for patients and increased risk of infection. …

Accepts healthy volunteers
  • 0 views
  • 25 Mar, 2022
  • 1 location
Reduced Intensity Haploidentical Transplantation for the Treatment of Primary or Secondary Myelofibrosis

graft failure as the graft failure rate has been historically higher with Haplo HCT than with other donor sources and higher with MF patients due to bone marrow fibrosis than in patients with other

  • 2 views
  • 28 Nov, 2021
  • 1 location
Efficacy and Safety Study of Aspirin for the Prevention of Renal Artery Stenosis in Renal Transplantation Recipients

The anastomotic and peripheral stenosis of the transplanted kidney artery is one of the most important causes of graft failure in renal transplantation. The injury of vascular intima and the

graft failure
  • 3 views
  • 26 Feb, 2022
  • 1 location
Reduced Intensity, Partially HLA Mismatched BMT to Treat Hematologic Malignancies

without having had acute grade III- IV GVHD or graft failure.

imatinib
sirolimus
graft versus host disease
lymphoma
fludarabine
  • 17 views
  • 12 Mar, 2022
  • 1 location
Extracorporeal Photopheresis and Early Cardiac Graft Vasculopathy (ECP-OCT)

posttransplant complication develops slowly over several years, and when diagnosed either by conventional coronary angiography or due to graft failure, it is often too advanced and difficult to treat since it is

  • 0 views
  • 24 Feb, 2022
  • 1 location