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Found 94 clinical trials
Safety and Immunogenicity of a Nipah Virus Vaccine

soluble glycoprotein vaccine) dosages. Different dosing regimens and number of doses will also be explored.

  • 1 views
  • 26 Jan, 2021
  • 1 location
Lenalidomide in Anti-MAG Neuropathy: Phase 1b Study

Anti-myelin-associated glycoprotein (MAG) is a rare autoimmune disorder of the peripheral nerves that presents with weakness, gait imbalance, and loss of sensation. It almost always occurs in

  • 66 views
  • 26 Jan, 2021
  • 2 locations
Atezolizumab and BCG in High Risk BCG na ve Non-muscle Invasive Bladder Cancer (NMIBC) Patients (BladderGATE)

glycoprotein that functions as an inhibitor of T-cells and plays a crucial role in suppression of cellular immune response. It is implicated in tumor immune escape by inducing apoptosis of activated antigen

tumor cells
transurethral resection
bladder cancer
carcinoma in situ
carcinoma of the bladder
  • 0 views
  • 25 Jan, 2021
Evaluation of the Safety and Efficacy of the Association of Ibrutinib and Daratumumab in Relapsed/Refractory Chronic Lymphocytic Leukemia With p53 Dysfunction

ibrutinib in combination with other agents. A body of evidence suggests that targeting the extracellular molecule CD38 might be an interesting option. CD38 is a transmembrane glycoprotein with multiple

  • 2 views
  • 07 Jul, 2021
  • 42 locations
Role of CYP2B6 CYP3A4 and MDR1 in the Metabolic Clearance of Methadone

The purpose of this study is to determine to what extent CYP2B6, CYP3A4, and MDR1 polymorphisms affect the metabolism of methadone.

methadone
bupropion
  • 229 views
  • 07 Nov, 2020
  • 1 location
ESTIMATION OF GINGIVAL CREVICULAR LEVEL OF YKL40

The presence of YKL- 40 an acute phase protein in both chronic periodontitis and rheumatoid arthritis. However, till date no studies has been done on the levels of gingival crevicular fluid YKL-40 following scaling and root planing, the present study which is first of its kind is designed to detect …

  • 6 views
  • 22 Jan, 2021
  • 1 location
Study Comparing Continuous Versus Fixed Duration Therapy With Daratumumab Lenalidomide and Dexamethasone for Relapsed Multiple Myeloma

The incorporation of proteasome inhibitors and immunomodulatory drugs into the standard of care has improved the outcome for patients with multiple myeloma (MM) over the past 10 years. However, most patients (>85%) still eventually relapse around 3-4 years after diagnosis, and ultimately die of their disease, despite salvage therapies. Relapse …

remission
azoospermia
dexamethasone
bortezomib
estrogen
  • 0 views
  • 23 Jan, 2021
  • 1 location
Daratumumab Intensified Treatment to Eligible MM New Patients CTD-Dara Induction Follow by Dara Consolidation

The best induction protocol to eligible multiple myeloma patients was not established. Combination of three drugs demonstrated better outcomes than two drugs combo. Nevertheless, until now four drugs combo did not prove gain against three drugs One of the three drugs protocol studied as induction was CTD scheme (cyclophosphamide+ thalidomide+dexamethasone). …

  • 0 views
  • 22 Jan, 2021
  • 1 location
Randomized Phase I/II of RAD001 in Advanced Hepatocellular Carcinoma (HCC)

The mTOR has been examined in hepatocellular carcinomas as well. This pathway is up-regulated in a proportion of hepatocellular carcinoma (HCC) and that rapamycin inhibits cell proliferation and blocks S6K phosphorylation. Inhibition of mTOR had been shown to suppress substantially the liver tumor growth. Nevertheless, inhibition of mTOR was demonstrated …

hepatitis
local therapy
TACE
chemoembolization
cirrhosis
  • 13 views
  • 07 Nov, 2020
  • 1 location
Study of a Live rNDV Based Vaccine Against COVID-19

This is a Phase 1, open-label, non-randomized, dose-escalation study using three doses and two schemes of administration of a recombinant vaccine against SARS-CoV-2 based on a viral vector (Newcastle Disease virus) in 90 healthy volunteers at a single research site in Mexico City.

  • 0 views
  • 02 Jun, 2021
  • 1 location