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Found 40 clinical trials
Add-on MEmaNtine to Dopamine Antagonism to Improve Negative Symptoms at First Psychosis

Antipsychotics affects the brain's dopamine system, and the drugs reduce delusions, hallucinations, and disorganized thinking, which are cardinal symptoms of psychotic disorders. However, negative symptoms e.g. anhedonia, avolition, and social withdrawal, as well as cognitive deficits, are not sufficiently treated. Memantine is used to treat Alzheimer's disease and affects the …

hallucinations
delusional disorder
schizoaffective disorder
amisulpride
schizophrenia
  • 0 views
  • 05 Sep, 2021
  • 1 location
Effect of Nutritional Supplementation and Pulmonary Rehabilitation on the Clinical Status of HF and COPD

Cardiovascular diseases (CVD) are the leading cause of death in the world and our country. The prevalence of Heart Failure (HF) is 1-2% in the adult population in developed countries, up to 10% among people 70 years of age. Concerning COPD, it is estimated that by 2030 will be the …

pulmonary function test
post bronchodilator spirometry
pulmonary rehabilitation
spirometry
heart failure
  • 0 views
  • 25 Jan, 2021
  • 1 location
A Pilot Study of Creatine Monohydrate as an Augmenting Agent for ECT in Persons With Major Depressive Disorder

We propose to determine if augmentation of electroconvulsive therapy (ECT) utilized for the treatment of major depressive disorder (MDD) with daily oral creatine will lead to an accelerated response to treatment, an overall increase in response rate, and will protect against cognitive adverse effects associated with ECT. We propose to …

major depressive disorder
depression
creatine monohydrate
electroconvulsive therapy
  • 0 views
  • 05 Jun, 2022
  • 1 location
Targeting Glutamine Metabolism to Prevent Diabetic Cardiovascular Complications (GLUTADIAB)

Experimental data suggest that glutamine catabolism in involved in the activation of macrophages by generating TCA(Tricarboxylic acid) intermediates that promote the pro-inflammatory

  • 0 views
  • 24 Jul, 2022
  • 1 location
Dietary Habits Metabolome Immune Profile and Microbiota in Patients With Bone Sarcoma

metabolic profile and lifestyle behaviors in patients with osteosarcoma and Ewing'sarcoma and only few preclinical studies are available. An in vitro study showed a higher glucose and glutamine consumption

  • 0 views
  • 11 Apr, 2021
  • 7 locations
Investigations of the Pathophysiology of Gilles de la Tourette Syndrome. Part 2: 7T MRI

) methods comparing patients with GTS and a control cohort. In Part 2 of this study, MRI and MRS at 7 Tesla are employed to investigate (i) the concentrations of Glu, glutamine and GABA in the corpus

Accepts healthy volunteers
  • 0 views
  • 15 Mar, 2022
Neuroimaging and Neuropsychological Outcomes in Urea Cycle Disorders (UCD)

In proximal urea cycle disorders (UCD), particularly ornithine transcarbamylase deficiency (OTCD), hyperammonemia (HA) causes increased brain glutamine (Gln) which perturbation is thought to be

deficiency
brain damage
cognitive impairment
myo-inositol
citrulline
  • 75 views
  • 16 Feb, 2022
  • 1 location
MR Imaging and MR Spectroscopy of HIV (HIV)

-infected humans have demonstrated significant changes of metabolites observed in the brain N-acetylaspartate, creatine, choline, glutamate, glutamine and myo-inositol with varying changes in different

Accepts healthy volunteers
  • 0 views
  • 23 May, 2022
  • 1 location
COVID-19 Vaccine Response in Sickle Cell Disease

The purpose of this study is to assess the antibody response to COVID-19 vaccination in a cohort of patients with sickle cell disease (SCD) and to assess vaccine and SCD related complications around the time of vaccination.

sickle hemoglobin
thalassemia
  • 0 views
  • 26 Jan, 2022
  • 1 location
Tracking Outcomes in Psychosis (TOPSY)

The investigators propose to study the brain processes that result in thought and language disorder and influence outcomes seen in patients with schizophrenia using a combination of brain scans and clinical assessments. The project will assess patients at various stages of psychosis (Clinical high risk, first episode and chronic stage …

psychosis
Accepts healthy volunteers
  • 65 views
  • 23 Feb, 2022
  • 1 location