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Found 8 clinical trials
Sickle Cell Disease, Hemechip

Sickle cell disease is very common in Nigeria. Early diagnosis is important to prevent or reduce serious complications from the disease and to enable children stay healthy. To this end, the investigators would like to test a new, simple and quick device called the HemeChip to determine if it can …

Accepts healthy volunteers
electrophoresis
  • 22 views
  • 26 Jan, 2022
  • 3 locations
The Role of the Microbiota-gut-brain Axis in Brain Development and Mental Health

The role of the microbiota-gut-brain axis in brain development and mental health

  • 98 views
  • 07 May, 2021
  • 1 location
Glutathione in Mild Cognitive Impairment

Elderly humans have an increased risk of dementia which begins as mild defects in memory called mild cognitive impairment. Glutathione (GSH), a key endogenous antioxidant has been linked to cognition. This exploratory study will investigate mechanisms linked to GSH for cognitive impairment (and improvement) by studying humans with mild cognitive …

dementia
antioxidants
  • 0 views
  • 25 Jan, 2022
  • 1 location
Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell Disease

Background Sickle cell disease (SCD) is an inherited hemoglobin disorder. People with SCD have an increased chance for getting blood clots. Researchers want to see if a dietary supplement called Isoquercetin can decrease levels of inflammation and blood clotting in people with SCD. Objective To see how Isoquercetin works in …

vaso-occlusive crisis
thalassemia
electrophoresis
blood transfusion
hydroxyurea
  • 0 views
  • 26 Jan, 2022
  • 1 location
MRS Measurement of Glutamate and GABA Metabolism in Brain

This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of [13]C as it is naturally metabolized from glucose to specific chemical transmitters. From this method, we can measure the rate of production of an important excitatory neurotransmitter (glutamate) as well as an inhibitory neurotransmitter …

Accepts healthy volunteers
  • 2 views
  • 22 Jan, 2022
  • 1 location
Reduction of MTX Levels After Glucarpidase Treatment in DLBCL Patients at Risk of CNS

Diffuse large B-cell lymphoma (DLBCL) is an aggressive subset of non-Hodgkin's lymphoma (NHL). Central nervous system (CNS) involvement in patients with NHL is a serious complication. The outcome of patients with CNS relapse is extremely poor, with a median survival of 4-6 months. One approach to reduce CNS relapse in …

  • 0 views
  • 15 Sep, 2021
  • 2 locations
Effect of Fermented Milk Containing Lactobacillus Casei Strain Shirota in Sarcopenia Elderly

Sarcopenia, which refers to the progressive loss of skeletal muscle mass and strength, shares many characteristics with other disease states typically associated with risks of falling and fracture, including osteoporosis, frailty, and obesity. Sarcopenia often is linked to an increase in connective tissue, muscle steatosis, impaired muscle metabolism, an increase …

tnf-alpha
nutritional supplementation
microbiota
grip
kidney disease
  • 0 views
  • 09 Aug, 2021
  • 4 locations
HLA Analysis in Autoimmune Encephalitis and Related Disorders: Part II

haplotypes associated with three types different of AE: anti-leucine-rich glioma inactivated 1 (LGI1), anti-contactin-associated protein-like 2 (CASPR2), and anti-glutamic acid decarboxylase (GAD

  • 0 views
  • 08 Apr, 2021
  • 1 location