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Found 96 clinical trials
The Effects of Sodium Phenylbutyrate on Circulating Branched Chain Amino Acids

The aim of this study is to reduce fasting circulating BCAA concentrations in volunteers using Sodium Phenylbutyrate. In addition, we aim investigate the effect of BCAA lowering on fasting blood glucose levels, insulin sensitivity measures and muscle metabolism.

  • 0 views
  • 08 Sep, 2021
  • 1 location
Effect of Dairy Products on Insulin Resistance

The objective of the study is to determine the effect of dairy consumption on insulin sensitivity in overweight and obese adults with prediabetes. Men and women (30-65 y) will be recruited from the greater Montreal area. Upon screening, those with prediabetes will complete a 2-wk run-in period in which participants …

oral glucose tolerance test
insulin
fasting
body mass index
insulin resistance
  • 0 views
  • 11 Jul, 2022
  • 1 location
Insulin Sensitivity After Breast Cancer

Epidemiological studies have revealed that 60-80% of women with breast cancer (BC) develop metabolic disorders that are similar to those observed in conditions like type 2 diabetes. These metabolic disorders, including insulin resistance, obesity, hyperinsulinemia, and glucose intolerance, are associated with increased BC recurrence and mortality. Skeletal muscle is the …

adjuvant chemotherapy
  • 0 views
  • 25 Aug, 2021
  • 1 location
Cut Down on Carbohydrate in the Dietary Therapy of Type 2 Diabetes - The Meal Box Study (CutDM-MealBox)

The cornerstone in the initial treatment of type 2 diabetes (T2D) is lifestyle modification, involving-among other things-a healthy diet. However, scientific evidence regarding optimal nutrition therapy for patients with T2D is insufficient. This clinical study will examine the effect of a carbohydrate-reduced high-protein (CRHP) diet compared to a conventional diabetes …

  • 0 views
  • 10 May, 2022
  • 1 location
Daytime vs. Delayed Eating Among Obese Adults

The randomized, cross-over design study is designed to determine how timing of eating affects weight, adiposity, energy metabolism, and gene expression. Obese participants will be provided isocaloric meals and snacks to be consumed in one of two prescribed eating conditions -- daytime eating and delayed eating.

Accepts healthy volunteers
  • 181 views
  • 28 Oct, 2022
  • 1 location
Treating Inflammation in Polycystic Ovary Syndrome to Ameliorate Ovarian Dysfunction (TIN-PCOS-AOD)

Polycystic Ovary Syndrome (PCOS) is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovaries. Insulin resistance (IR) is a common feature of PCOS, and the resultant hyperinsulinemia is theorized to promote hyperandrogenism in the disorder. However, 30-50% of women with PCOS who are lean do not have insulin resistance. Women with …

hyperinsulinemia
acne
gonadotropin
hirsutism
testosterone
  • 516 views
  • 09 Jun, 2022
  • 1 location
Face-it: Health Promotion for Women With Prior Gestational Diabetes (Face-it)

This project focuses on evaluating a postpartum health promotion intervention among families where the mother has prior gestational diabetes mellitus (GDM). The intervention focuses on the individual, family and health system levels. The aim is to increase quality of life and reduce the risk of type 2 diabetes among women …

gestational diabetes
oral glucose tolerance test
type 2 diabetes mellitus
diabetes
glucose tolerance test
  • 0 views
  • 25 May, 2022
  • 2 locations
Apolipoprotein E (APOE) Genotype Effects on Triglycerides and Blood Flow in the Human Brain

High fat feeding (HFF) increases the risk of Alzheimer's disease (AD) but individuals who carry the AD risk gene E4 paradoxically improve after acute HFF. The investigators propose to further study this phenomenon with a clinical study to assess cerebral blood flow which can be measured by a technique called …

apolipoprotein e
alzheimer's disease
Accepts healthy volunteers
  • 5 views
  • 24 Jan, 2022
  • 1 location
Novel Method of Pancreatic Islet Transplantation Into the Omentum

The investigators propose to conduct a pilot clinical study in 10 type 1 diabetic subjects suffering from hypoglycemia unawareness syndrome and episodes of severe hypoglycemia, in which therapy with transplantation of allogeneic pancreatic islets would be indicated according to current criteria at the Institute for Clinical and Experimental Medicine (IKEM). …

  • 0 views
  • 05 Sep, 2021
  • 1 location
Lifestyle Medicine Strategies for Combating Sleepiness and Fatigue in Professional Drivers

Sleep has a number of health benefits, including memory and learning, vitality and energy as well as high quality of life levels. Lack of sleep impairs judgment, impacts longevity and safety, and increases the risk of a number of diseases including obesity, hypertension, heart disease, diabetes, mood disorders, and impaired …

Accepts healthy volunteers
  • 0 views
  • 06 Nov, 2021
  • 1 location