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Found 119 clinical trials
Healthy Eating in Women at Risk of Gestational Diabetes (SAGE)

Healthy eating during pregnancy has favorable effects on markers related to diabetes (glucose tolerance) and is associated with lower gestational diabetes mellitus (GDM) risk. The cornerstone of GDM treatment is nutrition therapy but the latter often starts late in pregnancy and thus may not have the expected effects on glucose …

pcos
diabetes
Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 1 location
Biomarkers of Increased Free Living Sleep Time

This protocol will increase sleep duration in participants who maintain less than 6 hours sleep per night, to target the recommended 7 hours of sleep per night. The focus of this study is determine how increasing nightly sleep duration in these individuals who maintain less than 6 hours sleep per …

insulin
body mass index
hypersomnia
  • 25 views
  • 10 Jul, 2021
  • 2 locations
Effect of Novel Glucagon Receptor Antagonist REMD-477 on Glucose and Adipocyte Metabolism in T2DM

With REMD's glucagon receptor antagonist, the study team propose to provide a comprehensive examination of the effect of elevated plasma glucagon concentrations in Type 2 Diabetes Mellitus (T2D) patients on: (i) glucose tolerance; (ii) insulin sensitivity in liver, muscle, and adipocytes; (iii) beta cell function; (iv) adipocyte inflammation.

hemoglobin a1c
metformin
insulin
antidiabetic agents
glucagon
  • 0 views
  • 29 Dec, 2021
  • 1 location
Phenotyping Genetic Risk for Type 2 Diabetes

This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.

insulin resistance
Accepts healthy volunteers
impaired glucose tolerance
  • 12 views
  • 22 Mar, 2022
  • 1 location
Effect of Whole Fruit on Glycemic Control in Adults With Type 2 Diabetes

Diabetes costs the U.S. healthcare system more than any other disease, and nearly half of Americans will develop either diabetes or prediabetes in their lifetime. It is therefore critical to find new strategies to treat or reverse diabetes. One such approach is adopting a healthy diet, which can dramatically improve …

  • 0 views
  • 11 Dec, 2021
  • 1 location
Effect of Weight Loss on Body Composition and Metabolic Function in Women With Lipedema (Lipedema)

Lipedema is a disorder characterized by massive, bilateral accumulation of fat below the waist and in the legs. Enlargement of the lower extremities is often accompanied by leg pain and accumulation of fluid. Little is known about the functional changes that lead to fat accumulation and pain in women with …

Accepts healthy volunteers
  • 331 views
  • 09 Apr, 2022
  • 1 location
The Exercise And Colorectal Cancer Treatment Trial (EXACT)

This study will examine the biologic processes through which exercise may prevent disease recurrence in patients who have completed treatment for colorectal cancer.

stage iii colon cancer
aerobic exercise
  • 0 views
  • 24 Mar, 2022
  • 1 location
Role of Sweetness in Glucose Regulation (STS)

Data from several studies show that consuming a diet high in low-calorie sweeteners (LCS), mainly in diet sodas, is linked to the same metabolic disorders as consuming a diet high in added sugars, including an increased risk of developing type 2 diabetes. Sweet taste receptors, once thought to be unique …

diabetes
type 2 diabetes mellitus
sugars
insulin
Accepts healthy volunteers
  • 144 views
  • 07 Feb, 2022
  • 1 location
Bisphenol A and Muscle Insulin Sensitivity

This study examine oral bisphenol A consumption on muscle insulin sensitivity and hepatic glucose suppression. Half of the participants will receive a diet plus BPA and the other half will receive a diet plus no bisphenol A.

Accepts healthy volunteers
  • 0 views
  • 17 Feb, 2022
  • 1 location
An Open-Label, Fixed Sequence, Multiple Dose Study of Glucose and Insulin Associated Parameters: SEP-363856 vs Prior Antipsychotic (PA) Standard of Care in Subjects With Schizophrenia Suffering From Metabolic Dysregulation

A Clinical Study that will look at an investigational medication, SEP-363856 (called "study medication") in patients with schizophrenia and assess whether it changes: how the body processes (uses) glucose (blood sugar) how much insulin the pancreas can make. Insulin is a hormone that lowers blood sugar levels in the body. …

  • 0 views
  • 16 Oct, 2022
  • 3 locations