Found 102 clinical trials
Effect of Postprandial Insulin Administration of Faster-acting Insulin Analogue Versus Pre-prandial Administration of Acting-insulin Analogue in Cystic Fibrosis Related Diabetes (MIRE)
, insulin injection can result in an increased risk of postprandial hypoglycaemia, all the more so as CF patients exhibit decreased glucagon secretion. Recent progress in the development of new
- 0 views
- 12 May, 2022
- 1 location
Type 1 Diabetes Management Using a Very Low Carbohydrate Versus Standard Diet
. Two of the visits will also comprise additional metabolic studies to assess glucagon response and brain function during hypoglycemia by magnetic resonance imaging (MRI). Participants will have IV
- 4 views
- 05 Apr, 2023
- 1 location
The Clinical Application of 68Ga-NOTA-exendin-4 PET/CT in Detecting Insulinoma
The small insulinoma can not be detected by the CT or MRI. We use 68Ga-NOTA-exendin-4 positron emission tomography/computed tomography (PET/CT) to detect the insulinoma for the patient diagnosed with endogenous hyperinsulinemic hypoglycaemia. And the diagnostic value will be performed. A single dose of 37-111 Mega-Becquerel (MBq) 68Ga-NOTA-exendin-4 will be injected …
- 0 views
- 04 Oct, 2022
- 1 location
Effect of Gender Affirming Hormone Therapy on Glucose Metabolism
The study will test: whether estrogen treatment in transwomen is associated with improved insulin sensitivity and beta cell function whether testosterone treatment in transmen is associated with worsening insulin sensitivity and beta cell function whether estrogen therapy leads to enhanced immune response in older transwormen
- 24 views
- 23 Mar, 2022
- 1 location
Dapagliflozin and Hepatic Glucose Metabolism
the aim of this study is to examine the role of autonomic nervous system in the increase in hepatic glucose production in response to glucosuria caused by inhibition of renal glucose uptake
- 0 views
- 04 Oct, 2022
- 1 location
Managing DIabetes Remission After Combined Therapy in EarLy Stage of DiabetEs
Epidemiologic, social and economic burdens of type 2 diabetes mellitus (T2DM) keep rising worldwide. Implementation of T2DM preventive trategies is lagging behind. Metabolic surgery, very low calorie diet can induce T2DM remission, but so far for few patients. The investigators will assess the efficacy to cause T2DM remission (primary end …
- 2 views
- 23 Aug, 2021
- 1 location
Gut Microbiome and Sex as Risk Factors for Kidney Stones After Bariatric Surgery
This is a single-center study that aims to better understand how diet and sex affect the risk of kidney stones in people who have had gastric bypass surgery. Subjects will be asked to follow a special (clinic-provided) diet for six days and come to a research clinic for 3 study …
- 0 views
- 11 Apr, 2023
- 1 location
A Phase 1, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-and Multiple-Ascending Subcutaneous Doses of DR10624
DR10624 is an Fc fusion protein tri-agonist with balanced GLP-1R/GCGR/FGF21R agonizing activities that complement each other in regulating blood glucose and weight. The GLP-1R agonizing activity lowers blood glucose, GCGR agonizing activity reduces body weight by increasing energy consumption, and FGF21R agonizing activity reduces blood glucose and lipid content. The …
- 0 views
- 04 Oct, 2022
- 1 location
Young Adults With Early-onset Obesity Treated With Semaglutide -The RESETTLE Study (RESETTLE)
Introduction: Obesity prevalence is particularly pronounced among adolescents. Currently available treatment options consists of structured lifestyle interventions. However, 25 % of adolescents do not respond to lifestyle treatment, why new effective treatment strategies are needed. Therefore, the aim of this study is to investigate the effect of lifestyle interventions combined …
- 0 views
- 22 Oct, 2022
- 1 location
Sex Differences in Metabolism Following a High-fat Meal (HFM)
Long-term consumption (i.e., several weeks to months) of a diet that is high in fat (>35% daily calories from fat) is associated with the development of insulin resistance, a condition that can lead to a diagnosis of type 2 diabetes. Women tend to be better protected against the development of …
- 0 views
- 07 Oct, 2022
- 1 location