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Found 140 clinical trials
Prevention of Decompensation in Liver Cirrhosis

The purpose of this study is to determine whether losartan, an angiotensin II blocker prevents the sodium retention in patients with liver cirrhosis and by that reduces the fluid retention. Moreover is the purpose to asses whether losartan is antifibrotic.

angiotensin ii
cirrhosis
losartan
  • 14 views
  • 07 Nov, 2020
  • 1 location
Effect of Saxagliptin and Dapagliflozin on Endothelial Progenitor Cell in Patients With Type 2 Diabetes Mellitus

The Investigator hypothesize that Dapagliflozin will improve EPC number and function AND Saxagliptin in addition to Dapagliflozin (additive effect) may improve EPC number and function even more than Dapa alone, compared to placebo. The Investigator propose a 3-arm randomized, parallel group, longitudinal study of 16-week intervention duration. Participants will be …

glycosylated hemoglobin
peripheral artery disease
insulin
metformin
stroke
  • 15 views
  • 25 Jan, 2021
  • 1 location
Intramuscular Effect of Polymerized Type I Collagen on the Cytokine Storm in COVID-19 Patients

SARS-CoV-2 infection induces a hyperinflammatory syndrome, causing the acute respiratory distress syndrome, massive lung cell destruction and, as a plausible sequelae, pulmonary fibrosis in COVID-19 patients. Current focus has been on the development of novel immunosuppressant therapies, in order to control the cytokine storm in COVID-19 patients. Thus, the effect …

ivermectin
respiratory distress
d-dimer
fever
cough
  • 0 views
  • 24 Feb, 2021
  • 1 location
Effectiveness of Drainage by PCN vs. JJ in Patients With Symptoms of Obstructive Kidney Disease Caused by Urolithiasis

To investigate the effectiveness of percutaneous nephrostomy catheter placement versus retrograde double J catheter placement in patients with symptoms of obstructive kidney disease (with either infection and/or pain and/or kidney function deterioration) caused by urolithiasis.

  • 0 views
  • 26 Jan, 2021
  • 1 location
Dobutamine vs Adenosine CMR Study

This is a single centre, prospective diagnostic accuracy study to assess the comparative sensitivity of dobutamine versus adenosine for detection of severe non-infarct epicardial coronary artery stenosis in subjects with reduced LV EF ( EFed referred for clinical coronary angiography for investigation of symptoms or to establish the cause heart …

cardiac mri
perfusion imaging
coronary artery stenosis
MRI
angiography
  • 2 views
  • 05 May, 2021
  • 1 location
Low Energy Shockwave Therapy (LE-SWT): A Novel Treatment for Chronic Kidney Disease

The investigators aim to investigate whether low energy shockwave therapy (LE-SWT) can preserve kidney function in diabetic patients. Participants in this study will receive LE-SWT treatment 6 times over 3 weeks. The treatment is non-invasive and has no known side effects. Previous studies have shown that LE-SWT induces angiogenesis. The …

diabetes
tubular
renal failure
nephropathy
kidney biopsy
  • 226 views
  • 23 Jan, 2021
  • 1 location
Pulmonary Optical Coherence Tomography in COVID-19 Patients

To evaluate by intravascular OCT study the presence of microvascular pulmonary thrombosis in patients with COVID-19, high D-dimer levels and contrast CT scan negative for pulmonary thrombosis. We'll also evaluate the extension of microvascular pulmonary thrombosis in patients with contrast CT scan positive for pulmonary embolism in areas where contrast …

ct scan
d-dimer
interleukin-6
clot
diagnostic procedures
  • 17 views
  • 06 Mar, 2021
  • 2 locations
Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.

The purpose of this study is to determine whether nitric oxide is effective in the treatment of acute kidney injury in cardiac surgical patients with sign and laboratory data suggesting endothelial dysfunction undergoing prolonged cardiopulmonary bypass.

renal replacement
replacement therapy
cardiopulmonary bypass
kidney function tests
renal injury
  • 19 views
  • 07 Mar, 2021
DCE-CT of Thoracic Tumors as an Early Biomarker for Treatment Monitoring in Comparison With Morphologic Criteria

DCE-CT of thoracic tumors as an early biomarker for treatment monitoring in comparison with morphologic criteria. Rationale of the clinical investigation For the evaluation of response to anti-tumoral therapy in thoracic tumors, merely morphologic information is often not sufficient for early response evaluation as dimensions of the oncologic lesions are …

  • 0 views
  • 14 Feb, 2021
  • 1 location
Preoperative Endoscopic Treatment With Fosfomycin and Metronidazole in Patients With Right-sided Colon Cancer and Colon Adenoma (MEFO-trial)

Clinical studies have shown that patients with right-sided colon cancer have reduced progression-free and overall survival compared to patients with left-sided colon cancer. At the same time, patients with right-sided colon adenomas have a higher risk of developing interval cancers after endoscopic mucosal resection. Dysbiosis and known bacterial drivers play …

  • 0 views
  • 01 May, 2021
  • 3 locations