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Found 134 clinical trials
Allogeneic Regulatory Dendritic Cell (DCreg) Renal Study

This study will evaluate the safety and feasibility of treatment involving a single infusion of donor-derived regulatory dendritic cells (DCreg) in first time, living donor renal transplant recipients. DCreg will be prepared from monocytes obtained by leukapheresis from prospective (non-mobilized) living kidney donors and infused into the respective recipients 7 …

donor renal transplantation
Accepts healthy volunteers
live donor renal transplant
hepatitis b
  • 04 Feb, 2022
  • 1 location
Evaluation of a Renin Inhibitor, Aliskiren, Compared to Enalapril, in C3 Glomerulopathy

The aim of this cross-over trial is to assess aliskiren, a direct renin inhibitor, as a novel treatment to block complement activation in the kidneys and thereby attenuate renal disease and stabilize or improve kidney function and compare it to the currently used treatment with the angiotensin converting enzyme inhibitor, …

kidney biopsy
enzyme inhibitor
  • 22 Mar, 2022
  • 1 location
A Study of the Safety and Activity of Sparsentan for the Treatment of Incident Patients With Immunoglobulin A Nephropathy (SPARTAN)

To determine the nephroprotective potential of treatment with sparsentan in patients newly-diagnosed with immunoglobulin A nephropathy (IgAN) (ie, incident patients) who have not received prior angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) therapy.

enzyme inhibitor
immunoglobulin a
  • 03 Jun, 2022
  • 1 location
Pegloticase for the Reduction of Uric Acid in Patients With Tumor Lysis Syndrome

This trial studies the effect of pegloticase in reducing uric acid levels in patients with hyperuricemia (high blood levels of uric acid) caused by tumor lysis syndrome. Tumor lysis syndrome occurs when the breakdown products of cancer cells, such as uric acid, enter the blood stream. High levels of uric …

  • 11 Jul, 2022
  • 1 location
Evaluation of Dosing Procedures of Chemotherapy Treatment (Carboplatin) With the Contrast Agent Iohexol

This trial studies how well iohexol works in helping doctors calculate the dose of carboplatin given to patients with cancer. Drugs used in chemotherapy, such as carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by …

  • 19 Jun, 2022
  • 82 locations
Treatment of Vascular Stiffness in ADPKD (TRAMPOLINE)

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease characterized by cystic kidneys and caused by mutations in the polycystic kidney disease and other rare genes. It is associated with salt-sensitive hypertension, which accounts for the majority of morbidity and mortality. About 70% of patients with …

  • 06 May, 2022
  • 1 location
Effects of Multidisciplinary Intensive Targeted Care in Improving Diabetes Outcomes: a Pilot Study in Singapore (IDEALS)

This study aims to investigate whether channeling purposefully structured resources to patients at high risk of developing diabetic complications to interdisciplinary team clinic consultations, interspersed with closer remote follow-up and aided by simple technology will be more effective than usual care in controlling diabetes mellitus, controlling multiple cardiovascular risk factors …

self monitoring
glycosylated hemoglobin
antihypertensive drugs
  • 07 Feb, 2022
  • 1 location
A Study of Retrograde Reperfusion of Renal Graft to Reduce Ischemic-reperfusion Injury

To evaluate whether retrograde venous reperfusion of a renal graft before antegrade arterial reperfusion can reduce ischemic-reperfusion injury. All registered eligible candidates for kidney transplant will be randomized to receive either retrograde venous, then arterial reperfusion or antegrade arterial reperfusion.

end-stage renal disease
kidney transplant
  • 22 Mar, 2022
  • 1 location
Ketogenic Dietary Patterns in Young Adults and Kidney Health

This study seeks to assess the kidney health effects of short-term healthful ketogenic diet in young, overweight adults.10 overweight (BMI 25-30 kg/m2) adult participants (ages 20-40 years) without major chronic conditions including diabetes, kidney, cardiac, or liver disease will receive an isocaloric, high protein and low carbohydrate ketogenic diet for …

Accepts healthy volunteers
  • 05 Jun, 2022
  • 1 location
Mechanisms of Diuretic Resistance in Heart Failure (MsDR)

This study will employ a randomized order, double-blind, repeated measures dose ranging design. This design was chosen in order to generate multiple within-subject serial loop diuretic dose response exposures. The overall study schema will include 50 diuretic resistant HF patients and 25 diuretic responsive heart failure (HF) patients.

heart failure
  • 19 Aug, 2022
  • 1 location