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Found 144 clinical trials
Study of Pharmacokinetics and Safety of Apraglutide in Participants With Normal and Impaired Kidney Function.

Study of pharmacokinetics and safety of apraglutide in participants with normal and impaired kidney function.

  • 0 views
  • 27 Jan, 2021
  • 2 locations
The Long-term Effect of Marine Omega-3 Fatty Acid Supplementation in Renal Transplantation

This is a long-term intervention study on the effects of marine n-3 PUFAs in renal transplantation. Our hypothesis is that patients treated with marine n-3 PUFA supplementation will have less decline in kidney transplant function compared to patients treated with placebo.

kidney transplant
  • 158 views
  • 26 Jan, 2021
  • 6 locations
Pharmacokinetics of MB-102 and Use of the Non-invasive Optical Renal Function Monitor (ORFM) Device in Subjects With Normal and Impaired Renal Function and a Range of Skin Color Types

This study is a pilot, safety, and pharmacokinetic study of MB-102 versus iohexol and the use of the non-invasive optical renal function monitor (ORFM) device in normal and compromised renal function participants with different skin color types.

immunosuppressive agents
kidney function tests
renal impairment
  • 0 views
  • 27 Jan, 2021
  • 4 locations
Renal Impairment Study of PF-06700841

The purpose of this study is to characterize the effect of kidney impairment on the blood concentrations of PF-06700841 and its major metabolite. Findings from this study will be used to develop dosing recommendations so that the dose and/or dosing interval may be adjusted appropriately in the presence of kidney …

renal function
nephropathy
body mass index
kidney function tests
renal impairment
  • 3 views
  • 17 Mar, 2021
  • 3 locations
Melatonin for Renal Protection in Patients Receiving Polymyxin B

This study has the objective to evaluate the effect in renal function of 30mg of Melatonin versus placebo in patients 18 years old treated with polymyxin B. The development of nephrotoxicity will be evaluated by RIFLE(Risk, Injury, Failure, Loss, End stage renal disease) score and KIM-1 urinary biomarker for the …

renal failure
kidney function tests
nephropathy
  • 0 views
  • 17 Feb, 2021
  • 2 locations
Follow-up Using Patient-Reported Outcome (PRO) Measures in Patients With Chronic Kidney Disease

This randomized controlled trial (RCT) will evaluate if PRO-based follow-up is at least as effective as usual outpatient follow-up in managing decline in renal function and maintaining patients' quality of life. Furthermore, we intend to characterize the target patient group that is suitable for PRO-based follow up in a group …

  • 0 views
  • 10 May, 2021
  • 1 location
A Study of the Safety and Activity of Sparsentan for the Treatment of Incident Patients With Immunoglobulin A Nephropathy

To determine the nephroprotective potential of treatment with sparsentan in patients newly-diagnosed with immunoglobulin A nephropathy (IgAN) (ie, incident patients) who have not received prior angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) therapy.

  • 0 views
  • 26 Jan, 2021
  • 1 location
ASV for Sleep Apnea After Myocardial Infarction

The aim of this randomized controlled trial is to test the effect of 12 weeks Adaptive Servo-Ventilation (ASV) therapy (additionally to optimal medical management of myocardial infarction) on myocardial salvage (MSI=myocardial salvage/area at risk, primary endpoint).

myocardial infarction
electrocardiogram
adaptive servo-ventilation
  • 3 views
  • 25 Jan, 2021
  • 6 locations
Effect of Exenatide LAR or Dulaglutide on the Variability of 24-hour Heart Rate and Blood Pressure in Type 2 Diabetes

Mortality due to cardiovascular problems is increased by having Diabetes Mellitus type 2 (DM2), related to the time of evolution and glucose levels or if alterations in blood pressure coexist. With this variability there is greater damage to the target organ and in patients with DM2 the process is more …

glucagon-like peptide-1
glucagon-like peptide 1
thiazolidinedione
metformin
fasting
  • 1 views
  • 24 Jan, 2021
  • 1 location
Ferumoxytol as a Contrast Agent for Pulmonary Magnetic Resonance Angiography

This proposal is based on findings from our previous work involving ferumoxytol-enhanced cardiac magnetic resonance angiography. The resolution of the pulmonary vasculature based on our previous imaging protocol was exceptional (PMID: 26786296). In the Partners Healthcare System between January 1, 2014 and January 1, 2015 there were 541 patients evaluated …

diagnostic procedures
angiography
assisted ventilation
EGFR
  • 0 views
  • 05 Jun, 2021
  • 1 location