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Found 145 clinical trials
Renal Impairment Study of PF-06700841

The purpose of this study is to characterize the effect of kidney impairment on the blood concentrations of PF-06700841 and its major metabolite. Findings from this study will be used to develop dosing recommendations so that the dose and/or dosing interval may be adjusted appropriately in the presence of kidney …

renal impairment
kidney function tests
renal function test
body mass index
  • 17 Mar, 2021
  • 3 locations
Pilot to Examine Risk and Feasibility of Remote Management of BP From CKD Through ESRD

The transition from chronic kidney disease (CKD) to end-stage renal disease ESRD is a vulnerable and challenging period of time for patients and providers. Suboptimal control of blood pressure is known to be common in patients with the advanced stages of CKD, and may contribute to their elevated risk of …

systolic blood pressure
renal failure
cardiovascular morbidity
  • 16 Jun, 2021
  • 1 location
Effect of Exenatide LAR or Dulaglutide on the Variability of 24-hour Heart Rate and Blood Pressure in Type 2 Diabetes

Mortality due to cardiovascular problems is increased by having Diabetes Mellitus type 2 (DM2), related to the time of evolution and glucose levels or if alterations in blood pressure coexist. With this variability there is greater damage to the target organ and in patients with DM2 the process is more …

glucagon-like peptide-1
fasting blood glucose
  • 24 Jan, 2021
  • 1 location
ASV for Sleep Apnea After Myocardial Infarction

The aim of this randomized controlled trial is to test the effect of 12 weeks Adaptive Servo-Ventilation (ASV) therapy (additionally to optimal medical management of myocardial infarction) on myocardial salvage (MSI=myocardial salvage/area at risk, primary endpoint).

adaptive servo-ventilation
myocardial infarction
  • 25 Jan, 2021
  • 6 locations
Evaluation of Dosing Procedures of Chemotherapy Treatment (Carboplatin) With the Contrast Agent Iohexol

This trial studies how well iohexol works in helping doctors calculate the dose of carboplatin given to patients with cancer. Drugs used in chemotherapy, such as carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by …

  • 10 Aug, 2021
  • 68 locations
Protocol Biopsies in High-risk Renal Transplant Recipients

The present study aims to evaluate the usefulness of protocol biopsies in a cohort of renal transplant patients of high immunological risk for graft injury and loss.

flow cytometry
kidney biopsy
percutaneous renal biopsy
antibody-mediated rejection
kidney transplant
  • 12 Sep, 2021
  • 1 location
Allogeneic Regulatory Dendritic Cell (DCreg) Renal Study

This study will evaluate the safety and feasibility of treatment involving a single infusion of donor-derived regulatory dendritic cells (DCreg) in first time, living donor renal transplant recipients. DCreg will be prepared from monocytes obtained by leukapheresis from prospective (non-mobilized) living kidney donors and infused into the respective recipients 7 …

donor renal transplantation
live donor renal transplant
hepatitis b
  • 13 May, 2021
  • 1 location
Patient-Derived Stem Cell Therapy for Diabetic Kidney Disease

The Researchers will assess the safety, tolerability, dosing effect, and early signals of efficacy of intra-arterially delivered autologous (from self) adipose (fat) tissue-derived mesenchymal stem/stromal cells (MSC) in patients with progressive diabetic kidney disease (DKD).

diabetic nephropathy
renal failure
  • 06 Mar, 2021
  • 1 location
A Study of the Safety and Activity of Sparsentan for the Treatment of Incident Patients With Immunoglobulin A Nephropathy

To determine the nephroprotective potential of treatment with sparsentan in patients newly-diagnosed with immunoglobulin A nephropathy (IgAN) (ie, incident patients) who have not received prior angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) therapy.

  • 26 Jan, 2021
  • 1 location
Follow-up Using Patient-Reported Outcome (PRO) Measures in Patients With Chronic Kidney Disease

This randomized controlled trial (RCT) will evaluate if PRO-based follow-up is at least as effective as usual outpatient follow-up in managing decline in renal function and maintaining patients' quality of life. Furthermore, we intend to characterize the target patient group that is suitable for PRO-based follow up in a group …

  • 10 May, 2021
  • 1 location