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Found 144 clinical trials
Pharmacokinetics of MB-102 and Use of the Non-invasive Optical Renal Function Monitor (ORFM) Device in Subjects With Normal and Impaired Renal Function and a Range of Skin Color Types

This study is a pilot, safety, and pharmacokinetic study of MB-102 versus iohexol and the use of the non-invasive optical renal function monitor (ORFM) device in normal and compromised renal function participants with different skin color types.

kidney function tests
renal impairment
immunosuppressive agents
  • 0 views
  • 27 Jan, 2021
  • 4 locations
Pilot to Examine Risk and Feasibility of Remote Management of BP From CKD Through ESRD

The transition from chronic kidney disease (CKD) to end-stage renal disease ESRD is a vulnerable and challenging period of time for patients and providers. Suboptimal control of blood pressure is known to be common in patients with the advanced stages of CKD, and may contribute to their elevated risk of …

systolic blood pressure
nephropathy
hypertension
renal failure
cardiovascular morbidity
  • 4 views
  • 25 Jan, 2021
  • 1 location
Renal Impairment Study of PF-06700841

The purpose of this study is to characterize the effect of kidney impairment on the blood concentrations of PF-06700841 and its major metabolite. Findings from this study will be used to develop dosing recommendations so that the dose and/or dosing interval may be adjusted appropriately in the presence of kidney …

kidney function tests
body mass index
renal function
renal function test
nephropathy
  • 3 views
  • 25 Jan, 2021
  • 3 locations
Study of Pharmacokinetics and Safety of Apraglutide in Participants With Normal and Impaired Kidney Function.

Study of pharmacokinetics and safety of apraglutide in participants with normal and impaired kidney function.

  • 0 views
  • 27 Jan, 2021
  • 2 locations
Melatonin for Renal Protection in Patients Receiving Polymyxin B

This study has the objective to evaluate the effect in renal function of 30mg of Melatonin versus placebo in patients 18 years old treated with polymyxin B. The development of nephrotoxicity will be evaluated by RIFLE(Risk, Injury, Failure, Loss, End stage renal disease) score and KIM-1 urinary biomarker for the …

kidney function tests
renal failure
nephropathy
  • 0 views
  • 17 Feb, 2021
  • 2 locations
ASV for Sleep Apnea After Myocardial Infarction

The aim of this randomized controlled trial is to test the effect of 12 weeks Adaptive Servo-Ventilation (ASV) therapy (additionally to optimal medical management of myocardial infarction) on myocardial salvage (MSI=myocardial salvage/area at risk, primary endpoint).

myocardial infarction
electrocardiogram
adaptive servo-ventilation
  • 3 views
  • 25 Jan, 2021
  • 6 locations
Allogeneic Regulatory Dendritic Cell (DCreg) Renal Study

This study will evaluate the safety and feasibility of treatment involving a single infusion of donor-derived regulatory dendritic cells (DCreg) in first time, living donor renal transplant recipients. DCreg will be prepared from monocytes obtained by leukapheresis from prospective (non-mobilized) living kidney donors and infused into the respective recipients 7 …

hepatitis b
live donor renal transplant
ifng
donor renal transplantation
  • 24 views
  • 24 Jan, 2021
  • 1 location
Evaluation of Dosing Procedures of Chemotherapy Treatment (Carboplatin) With the Contrast Agent Iohexol

This trial studies how well iohexol works in helping doctors calculate the dose of carboplatin given to patients with cancer. Drugs used in chemotherapy, such as carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by …

  • 56 views
  • 25 Jan, 2021
  • 68 locations
Patient-Derived Stem Cell Therapy for Diabetic Kidney Disease

The Researchers will assess the safety, tolerability, dosing effect, and early signals of efficacy of intra-arterially delivered autologous (from self) adipose (fat) tissue-derived mesenchymal stem/stromal cells (MSC) in patients with progressive diabetic kidney disease (DKD).

diabetes
diabetic nephropathy
nephropathy
hypertension
dialysis
  • 19 views
  • 06 Mar, 2021
  • 1 location
Protocol Biopsies in High-risk Renal Transplant Recipients

The present study aims to evaluate the usefulness of protocol biopsies in a cohort of renal transplant patients of high immunological risk for graft injury and loss.

kidney transplant
flow cytometry
percutaneous renal biopsy
antibody-mediated rejection
kidney biopsy
  • 0 views
  • 24 Jan, 2021
  • 1 location