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Found 25 clinical trials
Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer

This phase I trial studies the side effects and best dose of MDM2 inhibitor KRT-232 in treating patients with glioblastoma (brain cancer) that is newly diagnosed or has come back (recurrent). MDM2 inhibitor KRT-232 may stop the growth of tumor cells by blocking some of the enzymes needed for cell …

glioblastoma multiforme
hydroxychloroquine
corticosteroids
serum pregnancy test
interleukins
  • 127 views
  • 19 Jun, 2021
  • 3 locations
Whole Brain Radiation Therapy With Standard Temozolomide Chemo-Radiotherapy and Plerixafor in Treating Patients With Glioblastoma

This phase II trial studies how well whole brain radiation therapy works with standard temozolomide chemo-radiotherapy and plerixafor in treating patients with glioblastoma (brain tumor). Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Drugs used in chemotherapy, such as temozolomide, work in different ways to …

glioblastoma multiforme
tumor cells
ct scan
cancer
brain tumor
  • 22 views
  • 15 May, 2021
  • 1 location
Genetically Engineered HSV-1 Phase 1 Study for the Treatment of Recurrent Malignant Glioma

To determine the safety and tolerability of the maximum dose for laboratory engineered Herpes Simplex Virus-1 in patients who would not be eligible for surgical resection of recurrent glioma To determine the safety and tolerability of the maximum dose for laboratory engineered Herpes Simples Virus-1 in patients who would benefit …

  • 139 views
  • 24 Jan, 2021
  • 1 location
Tinostamustine With or Without Radiation Therapy in Treating Patients With Newly Diagnosed MGMT-Unmethylated Glioblastoma

This phase I trial studies the side effects and best dose of tinostamustine (EDO-S101) given with or without radiation therapy in treating patients with newly diagnosed MGMT-unmethylated glioblastoma. Tinostamustine may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth in patients with glioblastoma.

tumor cells
glioblastoma multiforme
platelet count
temozolomide
MRI
  • 63 views
  • 31 Jan, 2021
  • 2 locations
Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG

The goal of this study is to estimate the efficacy of encorafenib and binimetinib as measured by radiographic response in recurrent high-grade primary brain tumors.

steroid therapy
primary brain neoplasm
hydroxychloroquine
serum pregnancy test
binimetinib
  • 24 views
  • 02 Jun, 2021
  • 9 locations
Phase 1b Study PVSRIPO for Recurrent Malignant Glioma in Children

xanthoastrocytoma) or WHO Grade IV malignant glioma (glioblastoma, gliosarcoma). A secondary objective is to estimate overall survival (OS) in this population.

glioblastoma multiforme
atypical teratoid/rhabdoid tumor
platelet count
astrocytoma
oligodendroglioma
  • 64 views
  • 04 Apr, 2021
  • 1 location
Oncolytic Adenovirus DNX-2401 in Treating Patients With Recurrent High-Grade Glioma

This phase I trial studies best dose and side effects of oncolytic adenovirus DNX-2401 in treating patients with high-grade glioma that has come back (recurrent). Oncolytic adenovirus DNX-2401 is made from the common cold virus that has been changed in the laboratory to make it less likely to cause an …

investigational agent
platelet count
astrocytoma
anaplastic astrocytoma
recurrent tumor
  • 2 views
  • 07 May, 2021
  • 1 location
Trial of C134 in Patients With Recurrent GBM

The purpose of this project is to obtain safety information in small groups of individuals, scheduled to receive escalating doses of C134, a cancer killing virus (HSV-1) that has been genetically engineered to safely replicate and kill glioma tumor cells. Safety will be assessed at each dose level before proceeding …

  • 14 views
  • 13 Jun, 2021
  • 1 location
A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas

This is a study to determine the safety and efficacy of the drug, mebendazole, when used in combination with standard chemotherapy drugs for the treatment of pediatric brain tumors. Mebendazole is a drug used to treat infections with intestinal parasites and has a long track record of safety in humans. …

glioblastoma multiforme
astrocytoma
chemotherapy drug
carboplatin
corticosteroids
  • 218 views
  • 13 Mar, 2021
  • 1 location
Nivolumab and Temozolomide Versus Temozolomide Alone in Newly Diagnosed Elderly Patients With GBM

be eligible to join this study if you are aged 65 years or above, with newly diagnosed histologically confirmed GBM (WHO grade IV glioma including gliosarcoma) following surgery. The study

temozolomide
gliosarcoma
renal function test
  • 17 views
  • 02 May, 2021
  • 20 locations