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Found 25 clinical trials
Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

This randomized phase II trial studies how well dose-escalated photon intensity-modulated radiation therapy (IMRT) or proton beam radiation therapy works compared with standard-dose radiation therapy when given with temozolomide in patients with newly diagnosed glioblastoma. Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells and …

contrast-enhanced magnetic resonance imaging
glioblastoma multiforme
karnofsky performance status
temozolomide
absolute neutrophil count
  • 317 views
  • 08 Mar, 2021
  • 43 locations
DSC-MRI in Measuring Relative Cerebral Blood Volume for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma

This phase II trial studies how well dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) works in measuring relative cerebral blood volume (rCBV) for early response to bevacizumab in patients with glioblastoma that has come back. DSC-MRI may help evaluate changes in the blood vessels within the cancer to determine a …

EGFR
cancer
contrast-enhanced magnetic resonance imaging
MRI
gliosarcoma
  • 30 views
  • 25 Jan, 2021
  • 26 locations
Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma

This phase II/III trial compares the usual treatment with radiation therapy and temozolomide to radiation therapy in combination with immunotherapy with ipilimumab and nivolumab in treating patients with newly diagnosed MGMT unmethylated glioblastoma. Radiation therapy uses high energy photons to kill tumor and shrink tumors. Chemotherapy drugs, such as temozolomide, …

cancer
flair
gliosarcoma
glioblastoma multiforme
brain tumor
  • 0 views
  • 12 May, 2021
  • 119 locations
Nedisertib and Radiation Therapy Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma

unmethylated glioblastoma or gliosarcoma. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Nedisertib may further stop the growth of tumor cells by blocking an ezyme needed for

aptt
gliosarcoma
karnofsky performance status
temozolomide
dexamethasone
  • 0 views
  • 09 May, 2021
ERC1671/GM-CSF/Cyclophosphamide for the Treatment of Glioblastoma Multiforme

plus Placebo Pill with Bevacizumab in treating patients with recurrent/progressive, bevacizumab nave glioblastoma multiforme and gliosarcoma (World Health Organization (WHO) grade IV malignant gliomas

placebo pill
steroid therapy
gliosarcoma
glioblastoma multiforme
bevacizumab
  • 53 views
  • 03 Mar, 2021
  • 1 location
Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

Background A glioblastoma is a tumor in the brain. It is treated with surgery, chemotherapy and radiation therapy. However, most people s tumors come back after therapy. When the tumor grows back, surgery or chemotherapy may not be possible or may no longer work. Repeat radiation therapy or re-irradiation, is …

cytotoxic chemotherapy
gliosarcoma
glioblastoma multiforme
bevacizumab
combined modality therapy
  • 41 views
  • 12 May, 2021
  • 1 location
Selinexor (KPT-330) in Combination With Temozolomide and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma

Background Glioblastoma is a type of brain cancer. Treatments include radiation, chemotherapy, and surgery. But survival rates are poor. Researchers think that the drug selinexor, when combined with chemotherapy and radiation, might help. Objective To learn the highest dose of selinexor that people with brain cancer can tolerate when given …

cancer
gliosarcoma
glioblastoma multiforme
brain tumor
platelet count
  • 43 views
  • 02 Apr, 2021
  • 1 location
Mycophenolate Mofetil Combined With Radiation Therapy in Recurrent Glioblastoma

recurrent gliosarcoma.

karnofsky performance status
gliosarcoma
glioblastoma multiforme
mycophenolate mofetil
  • 0 views
  • 26 Jan, 2021
  • 1 location
Pembrolizumab and Standard Therapy in Treating Patients With Glioblastoma

This phase II trial studies the side effects and how well pembrolizumab works in combination with standard therapy in treating patients with glioblastoma. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow …

cancer
external beam radiation therapy
glioblastoma multiforme
erythropoietin
beam radiation
  • 72 views
  • 26 Jan, 2021
  • 2 locations
Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel for Recurrent Glioblastoma

Paclitaxel is among the most active agents against glioblastoma in preclinical models. However, its clinical use has been hampered by the blood-brain barrier (BBB). In this trial we will implant a novel device with 9 ultrasound emitters allowing to temporarily and reversibly open the BBB immediately prior to chemotherapy infusion …

karnofsky performance status
contrast-enhanced magnetic resonance imaging
recurrent tumor
corticosteroids
glioblastoma multiforme
  • 22 views
  • 25 Jan, 2021
  • 1 location