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Found 18 clinical trials
Inducing a Hypothyroxinemic State in Patients With Recurrent Glioblastoma or Gliosarcoma

This early phase I trial studies the safety and feasibility of inducing a hypothyroxinemic state in patients with glioblastoma or gliosarcoma that has come back (recurrent). This trial aims to

  • 0 views
  • 08 Mar, 2022
  • 1 location
Natural Progesterone for the Treatment of Recurrent Glioblastoma

This early phase I trial identifies the best dose, possible benefits and/or side effects of natural progesterone in treating patients with glioblastoma that has come back (recurrent). Progesterone is a type of hormone made by the body that plays a role in the menstrual cycle and pregnancy. Progesterone may help …

karnofsky performance status
recurrent glioblastoma
gliosarcoma
platelet count
MRI
  • 0 views
  • 30 Apr, 2022
  • 1 location
Phase I/II Study to Evaluate the Safety and Clinical Efficacy of Atezolizumab (Anti-PD-L1) in Combination With Cabozantinib in Patients With Recurrent Glioblastoma (rGBM)

This phase I/II trial tests the safety and side effects of atezolizumab in combination with cabozantinib and whether they work to shrink tumors in patients with glioblastoma that has come back (recurrent). Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may …

  • 0 views
  • 10 Oct, 2022
  • 1 location
Mycophenolate Mofetil Combined With Radiation Therapy in Glioblastoma

This is a phase 0/1 dose-escalation trial to determine the maximum tolerated dose of Mycophenolate Mofetil (MMF) when administered with radiation, in patients with glioblastoma or gliosarcoma

mycophenolate mofetil
glioblastoma multiforme
karnofsky performance status
gliosarcoma
temozolomide
  • 0 views
  • 04 Oct, 2022
  • 1 location
DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma

This phase II trial studies how well dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) works in measuring relative cerebral blood volume (rCBV) for early response to bevacizumab in patients with glioblastoma that has come back. DSC-MRI may help evaluate changes in the blood vessels within the cancer to determine a …

glioblastoma multiforme
gliosarcoma
EGFR
brain mri
x-rays
  • 60 views
  • 17 Jun, 2022
  • 24 locations
Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine®) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma

This phase III trial compares the effect of adding lomustine to temozolomide and radiation therapy versus temozolomide and radiation therapy alone in shrinking or stabilizing newly diagnosed MGMT methylated glioblastoma. Chemotherapy drugs, such as lomustine and temozolomide, work in different ways to stop the growth of tumor cells, either by …

tumour resection
flair
tumor cells
gliosarcoma
temozolomide
  • 0 views
  • 04 Oct, 2022
  • 34 locations
Partial Brain RT, Temozolomide, Chloroquine, and TTF Therapy for the Treatment of Newly Diagnosed Glioblastoma

This trial studies the side effects of partial brain radiation therapy, temozolomide, chloroquine, and tumor treating fields therapy for the treatment of newly diagnosed glioblastoma. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Chemotherapy drugs, such as temozolomide, work in different ways to stop the …

contrast-enhanced magnetic resonance imaging
tumor cells
gliosarcoma
bilateral tubal ligation
x-rays
  • 0 views
  • 07 Oct, 2022
  • 1 location
Phase I Trial of DNA-PK Inhibitor (M3814) in Combination With Radiation and Adjuvant Temozolomide in Newly Diagnosed MGMT Unmethylated Glioblastoma

unmethylated glioblastoma or gliosarcoma. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Nedisertib may further stop the growth of tumor cells by blocking some of the enzymes

tumor cells
gliosarcoma
x-rays
temozolomide
MRI
  • 0 views
  • 16 Oct, 2022
  • 1 location
A Phase I Clinical Trial of Selinexor (KPT-330) in Combination With Temozolomide and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma

Background Glioblastoma is a type of brain cancer. Treatments include radiation, chemotherapy, and surgery. But survival rates are poor. Researchers think that the drug selinexor, when combined with chemotherapy and radiation, might help. Objective To learn the highest dose of selinexor that people with brain cancer can tolerate when given …

gliosarcoma
glioblastoma multiforme
brain tumor
astrocytoma
ct scan
  • 47 views
  • 23 Oct, 2022
  • 1 location
Phase II Trial Evaluating the Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

gliosarcoma to look at the changes in immune cells in the blood of those who take ipilimumab and nivolumab, along with temozolomide. Eligibility Adults ages 18 and older

gross total resection
gliosarcoma
complete resection
temozolomide
platelet count
  • 0 views
  • 20 Oct, 2022
  • 1 location