Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 22 clinical trials
Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

This randomized phase II trial studies how well dose-escalated photon intensity-modulated radiation therapy (IMRT) or proton beam radiation therapy works compared with standard-dose radiation therapy when given with temozolomide in patients with newly diagnosed glioblastoma. Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells and …

x-rays
absolute neutrophil count
glioblastoma multiforme
residual tumor
contrast-enhanced magnetic resonance imaging
  • 317 views
  • 08 Jul, 2021
  • 45 locations
DSC-MRI in Measuring Relative Cerebral Blood Volume for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma

This phase II trial studies how well dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) works in measuring relative cerebral blood volume (rCBV) for early response to bevacizumab in patients with glioblastoma that has come back. DSC-MRI may help evaluate changes in the blood vessels within the cancer to determine a …

x-rays
low grade glioma
recurrent glioblastoma
gliosarcoma
EGFR
  • 30 views
  • 25 Jan, 2021
  • 26 locations
Nedisertib and Radiation Therapy Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma

unmethylated glioblastoma or gliosarcoma. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Nedisertib may further stop the growth of tumor cells by blocking some of the enzymes

x-rays
aptt
gliosarcoma
neutrophil count
karnofsky performance status
  • 0 views
  • 10 Jun, 2021
Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma

This phase II/III trial compares the usual treatment with radiation therapy and temozolomide to radiation therapy in combination with immunotherapy with ipilimumab and nivolumab in treating patients with newly diagnosed MGMT unmethylated glioblastoma. Radiation therapy uses high energy photons to kill tumor and shrink tumors. Chemotherapy drugs, such as temozolomide, …

nivolumab
gliosarcoma
immunohistochemistry
cancer
glioblastoma multiforme
  • 0 views
  • 25 Jul, 2021
  • 126 locations
Selinexor (KPT-330) in Combination With Temozolomide and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma

Background Glioblastoma is a type of brain cancer. Treatments include radiation, chemotherapy, and surgery. But survival rates are poor. Researchers think that the drug selinexor, when combined with chemotherapy and radiation, might help. Objective To learn the highest dose of selinexor that people with brain cancer can tolerate when given …

platelet count
therapeutic agent
ct scan
gliosarcoma
cancer
  • 43 views
  • 31 May, 2021
  • 1 location
Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

Background A glioblastoma is a tumor in the brain. It is treated with surgery, chemotherapy and radiation therapy. However, most people s tumors come back after therapy. When the tumor grows back, surgery or chemotherapy may not be possible or may no longer work. Repeat radiation therapy or re-irradiation, is …

cytotoxic chemotherapy
recurrent glioblastoma
combined modality therapy
gliosarcoma
glioblastoma multiforme
  • 41 views
  • 27 Jul, 2021
  • 1 location
Mycophenolate Mofetil Combined With Radiation Therapy in Recurrent Glioblastoma

recurrent gliosarcoma.

mycophenolate mofetil
gliosarcoma
glioblastoma multiforme
karnofsky performance status
  • 0 views
  • 26 Jan, 2021
  • 1 location
Pembrolizumab and Standard Therapy in Treating Patients With Glioblastoma

This phase II trial studies the side effects and how well pembrolizumab works in combination with standard therapy in treating patients with glioblastoma. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow …

platelet count
thromboplastin
gliosarcoma
cancer
erythropoietin
  • 72 views
  • 26 Jan, 2021
  • 2 locations
Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel for Recurrent Glioblastoma

Paclitaxel is among the most active agents against glioblastoma in preclinical models. However, its clinical use has been hampered by the blood-brain barrier (BBB). In this trial we will implant a novel device with 9 ultrasound emitters allowing to temporarily and reversibly open the BBB immediately prior to chemotherapy infusion …

contrast-enhanced magnetic resonance imaging
recurrent glioblastoma
dexamethasone
corticosteroids
recurrent tumor
  • 22 views
  • 25 Jan, 2021
  • 1 location
Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer

This phase I trial studies the side effects and best dose of MDM2 inhibitor KRT-232 in treating patients with glioblastoma (brain cancer) that is newly diagnosed or has come back (recurrent). MDM2 inhibitor KRT-232 may stop the growth of tumor cells by blocking some of the enzymes needed for cell …

vegf
interleukins
thromboplastin
gliosarcoma
interferon
  • 127 views
  • 21 Jul, 2021
  • 3 locations