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Found 363 clinical trials
Modified CV Regimen in Optic Pathway Glioma

Optic pathway glioma (OPG) can result in visual deterioration. Symptomatic patients often report deficits in visual acuity (VA), visual field, visual-evoked potentials (VEPs), strabismus

vincristine
MRI
  • 0 views
  • 04 Oct, 2022
  • 1 location
Pilot Study of Mirtazapine for the Dual Tx of Depression and CINV in High-Grade Glioma Pts on TMZ

The purpose of the study is to estimate the ability of mirtazapine to reduce depression, nausea, and vomiting, and maintain weight in depressed glioma patients undergoing Temozolomide (TMZ

  • 1 views
  • 06 Feb, 2022
  • 1 location
Magnetic Resonance (MR) Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans and to Examine Metabolite Changes in Gliomas and Other Solid Tumors

The researchers think that the use of advanced MR imaging may help people with this disease, because it may better predict areas within a malignant glioma (brain tumor) that are at a high risk

MRI
brain tumor
malignant glioma
  • 16 views
  • 07 Oct, 2022
  • 1 location
Phase II Trial of Treatment Intensification for IDH Wildtype, Non-Histological Glioblastoma, Gliomas (IDH Wildtype Lower Grade Glioma Treatment Intensification)

This phase II trial studies how well temozolomide and radiation therapy work in treating patients with IDH wildtype historically lower grade gliomas or non-histological molecular glioblastomas

oligoastrocytoma
anaplastic astrocytoma
astrocytoma
astrocytoma, anaplastic
tumor cells
  • 0 views
  • 25 Oct, 2022
  • 1 location
CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas

nanoparticle formulation) and Gadolinium that can be given safely in children with newly diagnosed diffuse midline gliomas. All patients enrolled in the study will receive infusion of MTX110 and Gadolinium

seizures
epilepsy
platelet count
anesthesia
anticonvulsants
  • 1 views
  • 27 Feb, 2022
Hyperpolarized 13C-pyruvate Metabolic MRI With Infiltrating Gliomas

hyperpolarized metabolic MRI to diagnose intermediate to patients with infiltrating gliomas and examine the added utility of metabolic MRI over standard MRI imaging The FDA is allowing the use of

astrocytoma, anaplastic
MRI
oligodendroglioma
brain tumor
anaplastic astrocytoma
  • 0 views
  • 14 Jun, 2022
  • 1 location
gliomasPCV Only in 1p/19q Codeleted Anaplastic Gliomas

Patients with 1p/19q-codeleted anaplastic gliomas treated with RT + PCV are at risk of neurocognitive deterioration. Treating these patients with PCV alone (could reduce the risk of

  • 9 views
  • 21 Jan, 2021
  • 1 location
Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma

Diffuse Intrinsic Pontine Glioma (DIPG) is an aggressive childhood brain tumor that, despite many past clinical trials, has never been shown to respond to chemotherapy. Radiation therapy (RT) is

platelet transfusion
platelet count
renal function
prothrombin
neutrophil count
  • 0 views
  • 24 Mar, 2022
  • 1 location
Pembrolizumab, Olaparib, and Temozolomide for People With Glioma

This study will test the safety and effectiveness of a combination of pembrolizumab, olaparib, and temozolomide to see how well these drugs work when given together in people with a glioma that

corticosteroids
tumor progression
neutrophil count
bevacizumab
temozolomide
  • 0 views
  • 04 May, 2022
  • 7 locations
Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy (PLGG - MEKTRIC)

Pediatric low-grade glioma (PLGG) is a heterogeneous group of WHO grade I and II brain tumors, associated with a 10-year overall survival of 90%. It is the most common form of primary central

  • 0 views
  • 04 Oct, 2022
  • 1 location