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Found 521 clinical trials
ONC201 in Pediatric H3 K27M Gliomas

/refractory H3 K27M gliomas. Arm A will define the RP2D for single agent ONC201 in pediatric patients with glioma who are positive for the H3 K27M mutation (positive testing in CLIA laboratory) and have

nitrosoureas
renal function
mri of brain
glomerular filtration rate
dipg
  • 87 views
  • 07 Oct, 2022
  • 8 locations
Perampanel for the Reduction of Seizure Frequency in Patients With High-grade Glioma and Focal Epilepsy

This phase IV trial studies the side effects and how well perampanel works in reducing seizure frequency in patients with high-grade glioma and focal epilepsy. Perampanel is a drug used to treat

perampanel
epilepsy
seizure
  • 0 views
  • 10 Dec, 2021
  • 1 location
Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma (PNOC008)

, whole-exome sequencing (WES), targeted panel profile (UCSF 500 gene panel), and RNA-Seq. The current study will test the efficacy of such an approach in children with High-grade gliomas HGG

MRI
dipg
malignant glioma
diffuse intrinsic pontine glioma
epilepsy
  • 24 views
  • 04 Oct, 2022
  • 12 locations
Nivolumab in Combination With Temozolomide and Radiotherapy in Children and Adolescents With Newly Diagnosed High-grade Glioma (NIVOGLIO)

Multicenter, open label, prospective study including successively a phase I trial and then a phase II trial Phase I : Open label, non-randomized, safety run study in nine patients. In case of safety issue a -1 dose level will be tested. Phase II : Open label, non randomized, efficacy study …

platelet count
malignant glioma
astrocytoma
renal function
blood transfusion
  • 1 views
  • 26 Feb, 2022
  • 1 location
AZD1390 in Recurrent Grade IV Glioma Patients

This is an open-label, single-center Phase 0/1b study that will enroll at least 14 participants with recurrent WHO Grade IV Glioma requiring re-radiation. The trial will be composed of a Phase 0

antiepileptic
temozolomide
amylase
neutrophil count
lipase
  • 0 views
  • 06 Apr, 2022
  • 1 location
Study of Icapamespib (PU-AD) in Patients With Recurrent Malignant Glioma (Glio)

This is a 2-part multicenter Phase 1b study designed to test icapamespib in patients with recurrent brain lesions. Part 1 of the trial will be a standard 3 by 3 dose escalation design where different doses are examined. Part 2 will be a dose expansion cohort to further evaluate the …

  • 0 views
  • 30 May, 2022
  • 5 locations
MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma

This phase I trial studies best dose and side effects of oncolytic adenovirus DNX-2401 in treating patients with high-grade glioma that has come back (recurrent). Oncolytic adenovirus DNX-2401

gliosarcoma
nitrosoureas
astrocytoma
recurrent malignant glioma
recurrent tumor
  • 10 views
  • 04 Oct, 2022
  • 1 location
Modified CV Regimen in Optic Pathway Glioma

Optic pathway glioma (OPG) can result in visual deterioration. Symptomatic patients often report deficits in visual acuity (VA), visual field, visual-evoked potentials (VEPs), strabismus

MRI
vincristine
  • 0 views
  • 04 Oct, 2022
  • 1 location
D2C7-IT With Atezolizumab for Recurrent Gliomas

with recurrent World Health Organization (WHO) grade IV malignant glioma at the Preston Robert Tisch Brain Tumor Center (PRTBTC) at Duke.

platelet count
malignant glioma
brain tumor
estrogen
atezolizumab
  • 0 views
  • 06 Apr, 2022
  • 1 location
LIQUID BIOPSY IN Low-grade Glioma Patients (GLIOLIPSY)

, recent reports suggest the possible presence of circulating tumor cells (CTCs) in blood of high-grade glioma patients. Beside CTCs, other circulating biomarkers have been recently investigated in glioma

MRI
  • 0 views
  • 26 Mar, 2022
  • 1 location