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Found 521 clinical trials
Pembrolizumab (MK-3475) in Patients With Recurrent Malignant Glioma With a Hypermutator Phenotype

The purpose of this study is to test if the study drug called pembrolizumab could control the growth or shrink the cancer but it could also cause side effects. Researchers hope to learn if the study drug will shrink the cancer by half, or prevent it from growing for at …

cancer
astrocytoma
MRI
blood transfusion
anaplastic astrocytoma
  • 0 views
  • 26 Jan, 2022
  • 10 locations
Convection-enhanced Delivery of OS2966 for Patients With High-grade Glioma Undergoing a Surgical Resection

The primary goal of this Phase 1 study is to determine if a new investigational drug, OS2966, when delivered directly to the brain of adult participants with recurrent/progressive high-grade

cytotoxic chemotherapy
cancer
platelet count
MRI
bevacizumab
  • 0 views
  • 04 Oct, 2022
  • 1 location
Telehealth Visits to Discuss Advanced Directives for Patients Newly Diagnosed With High Grade Glioma

High grade gliomas (HGGs) are rapidly progressive brain tumors resulting in death for most patients between 6 months and 2 years after diagnosis. It is important for patients with HGG to discuss

  • 0 views
  • 26 Nov, 2021
  • 1 location
A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

This is a pilot study that will evaluate disease status in children that have been newly diagnosed high-grade glioma with TRK fusion. The evaluation will occur after 2 cycles of the medication

  • 0 views
  • 04 Oct, 2022
  • 6 locations
Anlotinib to Malignant Brainstem Glioma

This study is a single-arm, open-label, phase II study of anlotinib combined with radiation in the treatment of patients with malignant brainstem glioma. Twenty five patients will be enrolled in

  • 0 views
  • 26 Jan, 2021
  • 1 location
Glioma Supra Marginal Incision Trial (G-SUMIT)

G-SUMIT is a pilot, phase II,randomized controlled trial to evaluate the feasibility of performing a large-scale trial in patients undergoing surgery for first-time diagnosis of high grade

  • 0 views
  • 29 May, 2022
  • 1 location
A Phase 1/2 Trial of Selinexor (KPT-330) and Radiation Therapy in Newly-Diagnosed Pediatric Diffuse Intrinsic Pontine Glioma (DIPG) and High-Grade Glioma (HGG)

diffuse intrinsic pontine glioma (DIPG) or high-grade glioma (HGG) with a genetic change called H3 K27M mutation. It also tests whether combination of selinexor and standard radiation therapy works to

anticonvulsants
cancer
MRI
complete resection
temozolomide
  • 0 views
  • 25 Oct, 2022
  • 18 locations
UNIty-Based MR-Linac Guided AdapTive RadiothErapy for High GraDe Glioma: A Phase 2 Trial (UNITED)

Glioblastoma (GBM) is a high grade glioma (brain tumor) that is treated with surgery or biopsy followed by radiotherapy (RT) given daily over 3 or 6 weeks with or without an oral chemotherapy

residual tumor
cancer
MRI
brain tumor
malignant glioma
  • 0 views
  • 24 Mar, 2022
  • 1 location
Neoadjuvant Carilizumab and Apatinib for Recurrent High-Grade Glioma

glioma patients is still very poor. The study aim to Evaluate the Safety and efficiency of Using the neoadjuvant therapy with Carilizumab and Apatinib in patients with Recurrent High-Grade Glioma.

  • 0 views
  • 25 Jan, 2021
  • 1 location
Talazoparib - Carboplatin for Recurrent High-grade Glioma With DDRd

In view of the strong biological rationale of employing PARP inhibition in high grade glioma, the current study purposes testing of talazoparib in a biomarker-enriched group of glioma

  • 0 views
  • 25 Aug, 2021
  • 1 location