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Found 509 clinical trials
Ph I/II Study of NMS-03305293+TMZ in Adult Patients With Recurrent Glioblastoma

Multicenter, randomized, open-label, non-comparative Phase 1/2 study on the safety and efficacy of the combination of NMS-03305293 and temozolomide (TMZ) in adult patients with diffuse gliomas

temozolomide
measurable disease
recurrent disease
oligodendroglioma
astrocytoma
  • 0 views
  • 05 Apr, 2022
  • 4 locations
Open Label, Multi-center Roll-over Study to Assess Long Term Safety in Patients Who Have Completed a Global Novartis or GSK Sponsored Dabrafenib and/or Trametinib Study

This study is to provide access for patients who are receiving treatment with dabrafenib and/or trametinib in a Novartis-sponsored Oncology Global Development, Global Medical Affairs or a former GSK-sponsored study who have fulfilled the requirements for the primary objective, and who are judged by the investigator as benefiting from continued …

trametinib
dabrafenib
  • 87 views
  • 17 Sep, 2022
  • 17 locations
A Study to Test the Efficacy, Safety, and Pharmacokinetics of Rozanolixizumab in Adult Study Participants With Leucine-Rich Glioma Inactivated 1 Autoimmune Encephalitis

The purpose of the study is to assess the efficacy of rozanolixizumab as measured by seizure freedom, change in cognitive function, use of rescue medication, onset of seizure freedom and to assess safety and tolerability.

  • 0 views
  • 29 Jul, 2022
  • 17 locations
Pediatric Long-Term Follow-up and Rollover Study

A roll-over study to assess long-term effect in pediatric patients treated with dabrafenib and/or trametinib.

trametinib
dabrafenib
  • 488 views
  • 06 May, 2022
  • 16 locations
Methionine PET/CT Studies In Patients With Cancer

The purpose of this study is to test the usefulness of imaging with radiolabeled methionine in the evaluation of children and young adults with tumor(s). Methionine is a naturally occurring essential amino acid. It is crucial for the formation of proteins. When labeled with carbon-11 (C-11), a radioactive isotope of …

sarcoma
essential amino acid
residual tumor
positron emission tomography
cancer
  • 53 views
  • 21 Jul, 2022
  • 1 location
Supramarginal Resection in Glioblastoma

Gliomas are the most common malignant brain tumor. Glioblastoma, WHO grade IV astrocytoma, is the most common subtype and unfortunately also the most aggressive subtype with median survival in

karnofsky performance status
temozolomide
tumor cells
supratentorial glioblastoma multiforme
astrocytoma
  • 0 views
  • 26 Oct, 2021
  • 20 locations
NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Screening Protocol

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

cns tumors
cellular therapy
olaparib
measurable disease
neutrophil count
  • 1032 views
  • 19 Sep, 2022
  • 107 locations
A Phase 2 Basket Study of the Oral TRK Inhibitor Larotrectinib in Subjects With NTRK Fusion-positive Tumors (NAVIGATE)

This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib is a drug that blocks the actions of these NTRK genes in cancer cells and can …

lung cancer
cancer
measurable disease
breast cancer
tyrosine
  • 163 views
  • 15 Sep, 2022
  • 129 locations
Molecular Analysis for Therapy Choice (MATCH)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

pertuzumab
antiretrovirals
measurable disease
neutrophil count
crizotinib
  • 6585 views
  • 14 Sep, 2022
  • 911 locations
Study on Tailored Treatment in Elderly Patients With Newly Diagnosed Primary Lymphoma of Central Nervous System (FIORELLA)

Primary central nervous system lymphomas are rare aggressive malignancies, usually treated in two steps: an induction phase (where a combination of chemotherapy is given) followed by a consolidation phase (where patients usually receive one of the following: whole-brain irradiation, chemotherapy supported by autologous stem-cell transplantation, other type of chemotherapy, or …

whole-brain radiotherapy
temozolomide
rituximab
methotrexate
cancer
  • 0 views
  • 13 May, 2022
  • 35 locations