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Found 510 clinical trials
A Vaccine Trial for Low Grade Gliomas

The study will assess the immunogenicity, safety and preliminary clinical efficacy of the glioma associated antigen (GAA)/tetanus toxoid (TT) peptide vaccine and poly-ICLC in HLA-A2+ children

corticosteroids
dexamethasone
toxoid
  • 62 views
  • 12 Aug, 2021
  • 1 location
Awake vs. Asleep Craniotomy for Non-eloquent Gliomas

control bodily functions (non-eloquent gliomas).

  • 0 views
  • 15 Feb, 2022
  • 1 location
Everolimus in Treating Patients With Recurrent or Progressive Low-Grade Glioma

studying how well everolimus works in treating patients with recurrent or progressive low-grade glioma.

  • 24 views
  • 07 Nov, 2020
  • 1 location
Study of Avatrombopag for Temozolomide-induced Thrombocytopenia in Glioma (APATIT-G)

The purpose of this study is to determine if using avatrombopag in patients with thrombocytopenia due to temozolomide treatment can safely improve a patient's platelet count and allow the patient to complete the temozolomide treatment course as planned.

small molecule
avatrombopag
platelet count
  • 0 views
  • 30 Jun, 2022
  • 1 location
Safety and Tolerability of Fb-PMT in Recurrent Glioblastoma

Glioblastoma is a highly aggressive and fatal form of primary malignant brain tumor with limited treatment options. fb-PMT affects a large group of cancer cell signaling pathways and thus may be effective in heterogeneous, treatment-resistant tumors such as Glioblastoma. fb-PMT also is actively transported across the blood-brain barrier into the …

karnofsky performance status
recurrent glioblastoma
cancer
brain tumor
  • 0 views
  • 04 Oct, 2022
  • 1 location
Functional and Ultrasound Guided Resection of Glioblastoma (FUTURE-GB)

Functional and ultrasound-guided resection of glioblastoma: assessing the use of additional imaging during surgery to improve outcomes for patients with glioblastoma brain tumours

  • 0 views
  • 18 Jun, 2022
  • 17 locations
Radiotherapy Versus Radiotherapy Combined With Temozolomide in High-risk Low-grade Gliomas After Surgery

patients with high-risk WHO grade 2 gliomas after surgery. However, procarbazine is not available in China. In clinical practice, Chinese doctors often use radiotherapy combined with temozolomide to treat

lomustine
temozolomide
vincristine
  • 1 views
  • 02 Mar, 2022
  • 1 location
Spectroscopic MRI Guided Proton Therapy in Assessing Metabolic Change in Pediatric Patients With Brain Tumors

This trial studies how well spectroscopic magnetic resonance imaging (MRI) guided proton therapy works in assessing metabolic change in pediatric patients with brain tumors. The non-invasive imaging, such as spectroscopic MRI may help to map the differences in tumor metabolism compared to healthy tissue without injection of any contrast agent.

  • 0 views
  • 15 Jun, 2022
  • 2 locations
A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM) (PNOC020)

The primary objective will be to demonstrate the manufacturing feasibility and safety, and to determine the maximum tolerated dose (MTD) of RNA-LP vaccines in (Stratum 1) adult patients with newly diagnosed GBM (MGMT unmethylated). Funding Source - FDA OOPD

  • 0 views
  • 20 Sep, 2022
  • 1 location
The Use of Focused Ultrasound and DCE K-trans Imaging to Evaluate Permeability of the Blood-Brain Barrier

multifocal disease and when long term and repetitive administration is required. This study seeks to investigate the efficacy of focused ultrasound. Patients with either low grade gliomas or

  • 0 views
  • 12 Sep, 2021
  • 1 location