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Found 330 clinical trials
An Open Label, Multi-center Roll-over Study to Assess Long-term Effect in Pediatric Patients Treated With Tafinlar (Dabrafenib) and/or Mekinist (Trametinib)

A roll-over study to assess long-term effect in pediatric patients treated with dabrafenib and/or trametinib.

trametinib
dabrafenib
  • 492 views
  • 29 Oct, 2022
  • 15 locations
Deciphering Mechanisms Underlying Cancer Immunogenicity (DECIDE)

CIN III cervical cancer (Cervical Intra-epithelial Neoplasia III cervical cancer), Other solid tumor types (including glioblastoma, NSCLC (Non-small cell lung cancer), anal cancer)

cancer of the ovary
cancer
cin 3
dysplasia
cervical lesion
  • 0 views
  • 04 Oct, 2022
  • 3 locations
Efficacy Study of 4CMenB (Bexsero®) to Prevent Gonorrhoea Infection in Gay and Bisexual Men (GoGoVax)

+ [GBM+], either HIV-negative and taking pre-exposure prophylaxis [PrEP], or HIV-positive with undetectable viral load <200copies/ml and a cluster of differentiation 4 [CD4] count >350 cells/cmm

  • 6 views
  • 26 Apr, 2022
  • 2 locations
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors (SPARTA)

The primary Phase 1 purpose of this study was to assess overall safety, tolerability and recommended Phase 2 dose (RP2D) of APL-101. The Phase 2 portion will assess efficacy of the dose determined in Phase 1 in individuals with Non-Small Cell Lung Cancer with c-Met EXON 14 Skip Mutations; individuals …

measurable disease
major surgery
cancer
c-MET
solid tumour
  • 326 views
  • 04 Oct, 2022
  • 85 locations
A Phase 2 Basket Study of the Oral TRK Inhibitor Larotrectinib in Subjects With NTRK Fusion-positive Tumors (NAVIGATE)

This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib is a drug that blocks the actions of these NTRK genes in cancer cells and can …

lung cancer
cancer
breast cancer
NTRK
tyrosine
  • 163 views
  • 21 Oct, 2022
  • 125 locations
Pivotal, Randomized, Open-label Study of Tumor Treating Fields (TTFields, 150kHz) Concomitant With Gemcitabine and Nab-paclitaxel for Front-line Treatment of Locally-advanced Pancreatic Adenocarcinoma

Brief Summary: The study is a prospective, randomized controlled phase III trial aimed to test the efficacy and safety of Tumor Treating Fields (TTFields) in combination with gemcitabine and nab-paclitaxel, for front line treatment of locally-advanced pancreatic adenocarcinoma.The device is an experimental, portable, battery operated device for chronic administration of …

advanced pancreatic adenocarcinoma
paclitaxel
cancer
metastasis
gemcitabine
  • 440 views
  • 14 Oct, 2022
  • 117 locations
Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)

Conduct a multicenter, open label Phase IIA trial of oral DCA in 40 surgical patients with recurrent GBM who have clinically indicated debulking surgery planned. No patients will be recruited at

brain tumor
temozolomide
  • 0 views
  • 07 Oct, 2022
  • 1 location
Tissue Autograft to Bypass the Blood Brain Barrier (BBB) in Human Glioblastoma Multiforme (GBM)

This study assesses the safety of using tissue autograft of a pedicled temporoparietal fascial (TPF) or pericranial flap into the resection cavity of newly diagnosed glioblastoma multiforme (GBM

neutrophil count
blood transfusion
karnofsky performance status
blood urea nitrogen
Accepts healthy volunteers
  • 42 views
  • 21 Oct, 2022
  • 1 location
Subventricular Zone (SVZ) and Temozolomide in Glioblastoma Multiforme

to deliver an higher than routine radiation dose to the subventricular zone which is an area of the brain that contains stem cells that some scientists believe may contribute to glioblastoma

gross total resection
temozolomide
complete resection
  • 30 views
  • 07 Oct, 2022
  • 3 locations
Vaccine Therapy for the Treatment of Newly Diagnosed Glioblastoma Multiforme (ATTAC-II)

glioblastoma (GBM) when given with stronger doses of routine chemotherapy.

dendritic cell vaccine
renal function
karnofsky performance status
renal function test
vaccine therapy
  • 500 views
  • 25 Mar, 2022
  • 2 locations