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Found 352 clinical trials
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A Phase II/III Randomized Trial Of Veliparib Or Placebo In Combination With Adjuvant Temozolomide In Newly Diagnosed Glioblastoma With MGMT Promoter Hypermethylation

A Phase II/III Randomized Trial Of Veliparib Or Placebo In Combination With Adjuvant Temozolomide In Newly Diagnosed Glioblastoma With MGMT Promoter Hypermethylation

glioblastoma
temozolomide
  • 164 views
  • 24 Nov, 2020
  • 1 location
featured
Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme (INTRAGO-II)

glioblastoma multiforme (GBM) can be improved by the addition of intraoperative radiotherapy (IORT) to standard radiochemotherapy.  

bevacizumab
MRI
cancer
  • 40 views
  • 11 Jun, 2020
  • 1 location
featured
CG01-GBM Standard Chemotherapy versus Chemotherapy Chosen by Cancer Stem Cell Chemosensitivity Testing in the Management of Patients with Recurrent Glioblastoma Multiforme (GBM)

People who were previously diagnosed with glioblastoma (Grade IV) or Grade III glioma, and now have evidence that their tumor has come back or has started to grow again, and who would otherwise be

glioblastoma
brain tumor
  • 117 views
  • 22 Dec, 2020
  • 1 location
featured
GBM AGILE An International, Seamless Phase II/III Responsive Adaptive Randomization Platform Trial Designed To Evaluate Multiple Regimens in Newly Diagnosed and Recurrent GBM

People with either a new diagnosis of glioblastoma or with evidence that their tumor has returned or started to grow again may be eligible.  This trial is studying multiple treatment

glioblastoma multiforme
brain tumor
  • 0 views
  • 22 Dec, 2020
  • 1 location
featured
Wake Forest WF-1801 A Single Arm, Pilot Study of Ramipril for Preventing Radiation - Induced Cognitive Decline in Glioblastoma (GBM) Patients Receiving Brain Radiotherapy

People who were just diagnosed with glioblastoma and have yet to get treatment may be eligible.  This trial is investigating whether a common blood pressure drug is helpful to prevent

brain tumor
cancer
  • 2 views
  • 22 Dec, 2020
  • 1 location
featured
OT-15-001 (STELLAR) A Phase 3, Randomized, Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma That Progress/Recur After irradiation and Adjuvant Temozolomide Chemotherapy

it has progressed to a glioblastoma (WHO grade IV astrocytoma) may be eligible to participate.  This study is comparing treatment with CCNU, which is a standard of care treatment, to

brain tumor
brain tumors
astrocytoma
  • 10 views
  • 22 Dec, 2020
  • 1 location
A Study of BLZ945 Single Agent or BLZ945 in Combination With PDR001 in Advanced Solid Tumors

> Dose escalation will be guided by a Bayesian logistic regression model with overdose control. Once MTD/ RP2D is declared, glioblastoma patients will be enrolled in the phase II part to further assess

  • 0 views
  • 18 Jan, 2021
  • 17 locations
Effect of Tumor Treating Fields (TTFields) (150 kHz) Concurrent With Standard of Care Therapies for Treatment of Stage 4 Non-small Cell Lung Cancer (NSCLC) Following Platinum Failure (LUNAR)

The study is a prospective, randomized controlled phase III trial aimed to test the efficacy and safety of TTFields, using the NovoTTF-100L System, concurrent with standard therapies for stage 4 NSCLC patients, following progression while on or after platinum based treatment.The device is an experimental, portable, battery operated device for …

docetaxel
  • 644 views
  • 19 Oct, 2020
  • 165 locations
Hypofractionated Stereotactic Radiotherapy in Recurrent Glioblastoma Multiforme

Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. The treatment comprises maximal safe resection followed by radiotherapy and chemotherapy. Despite appropriate

  • 15 views
  • 23 Jan, 2021
  • 1 location
Subventricular Zone (SVZ) and Temozolomide in Glioblastoma Multiforme

to deliver an higher than routine radiation dose to the subventricular zone which is an area of the brain that contains stem cells that some scientists believe may contribute to glioblastoma

temozolomide
complete resection
gross total resection
  • 30 views
  • 25 Jan, 2021
  • 3 locations