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Found 4 clinical trials
The Effect of Sitagliptin on Hypertension Arterial Stiffness Oxidative Stress and Inflammation

Recently a new category of antihyperglycemic therapy aiming to modulate the incretin system has emerged. These drugs induce insulin secretion without inducing hypoglycemia. The effect of the incretin modulators drugs on hypertension, arterial stiffness, inflammation and oxidative stress parameters have not been fully investigated yet.GLP-1 analogue has been suggested to …

heart disease
incretins
sitagliptin
dipeptidyl peptidase-4 inhibitor
arterial stiffness
  • 11 views
  • 07 Nov, 2020
  • 1 location
Intravenous Administration of BIIB093 (Glibenclamide) in the Treatment of Severe Cerebral Edema After Massive Cerebral Infarction

The current study is to assess efficacy and safety of intravenous (IV) BIIB093 to improve functional outcomes in subjects with LHI.

  • 0 views
  • 16 Jul, 2021
  • 1 location
Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction

The primary objective of Part 1 of the study is to determine if BIIB093 improves functional outcome at Day 90 as measured by the modified Rankin Scale (mRS) when compared with placebo in participants with Large Hemispheric Infarction (LHI). The secondary objectives of Part 1 of the study are to …

glyburide
MRI
ischemic stroke
glibenclamide
infarct
  • 217 views
  • 04 Sep, 2021
  • 223 locations
Safety and Efficacy of Glibenclamide Combined With Rt-PA in Acute Cerebral Embolism

This study is designed to evaluate the safety and efficacy of oral glibenclamide in acute ischemic stroke patients who under intravenous rt-PA thrombolysis.

ischemic stroke
alteplase
glibenclamide
plasminogen activator
tissue plasminogen activator
  • 5 views
  • 26 Jan, 2021
  • 8 locations