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Found 1020 clinical trials
EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors

This is a Phase 1 study of central nervous system (CNS) locoregional adoptive therapy with autologous CD4+ and CD8+ T cells that are lentivirally transduced to express an EGFR806 specific chimeric antigen receptor (CAR) and EGFRt. CAR T cells are delivered via an indwelling catheter into the tumor cavity or …

central nervous system tumor
supratentorial tumors
MRI
EGFR
mg++
  • 3 views
  • 25 Mar, 2022
  • 1 location
Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

This is a Phase 1 study of central nervous system (CNS) locoregional adoptive therapy with autologous CD4+ and CD8+ T cells lentivirally transduced to express a B7H3-specific chimeric antigen receptor (CAR) and EGFRt. CAR T cells are delivered via an indwelling catheter into the tumor resection cavity or ventricular system …

central nervous system tumor
MRI
supratentorial tumors
mg++
dipg
  • 8 views
  • 09 May, 2022
  • 1 location
Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers

This clinical trial is studying two immunotherapy drugs (nivolumab and ipilimumab) given together as a possible treatment for INI1-negative tumors.

human chorionic gonadotropin
cancer chemotherapy
kidney function tests
neutrophil count
monoclonal antibodies
  • 7 views
  • 05 Jun, 2022
  • 7 locations
A Study of DS-9606a in Patients With Advanced Solid Tumors

This study will assess the safety and tolerability of DS-9606a in patients with advanced solid tumors.

adenocarcinoma
cancer
cancer of the ovary
fallopian tube
carcinoma
  • 0 views
  • 17 Jun, 2022
  • 1 location
SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Approximately 90% of children with malignant brain tumors that have recurred or relapsed after receiving conventional therapy will die of disease. Despite this terrible and frustrating outcome, continued treatment of this population remains fundamental to improving cure rates. Studying this relapsed population will help unearth clues to why conventional therapy …

combined modality therapy
filgrastim
trametinib
conventional treatment
medulloblastoma
  • 224 views
  • 19 Apr, 2022
  • 1 location
Trial of Palbociclib in Second Line of Advanced Sarcomas With CDK4 Overexpression. (PalboSarc)

Non-randomized, open, two-cohort, phase II, multicenter national clinical trial. 20 sites in Spain. Cohort 1 includes soft-tissue sarcoma and osteosarcoma (21 patients), while Cohort 2 includes chordoma patients only (19 patients). Palbociclib will be administered orally at a dose of 125 mg once a day for 21 consecutive days followed …

gilbert's disease
absolute neutrophil count
serum bilirubin
sarcoma
soft tissue sarcoma
  • 17 views
  • 18 Jun, 2022
  • 19 locations
Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

The phase I portion of this study is designed for children or adolescents and young adults (AYA) with a diagnosis of a solid tumor that has recurred (come back after treatment) or is refractory (never completely went away). The trial will test 2 combinations of therapy and participants will be …

  • 0 views
  • 16 Jun, 2022
  • 2 locations
A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors

efficacy. These include neuroblastoma, high-grade gliomas, diffuse intrinsic pontine gliomas and other high-grade brain tumors, and germ cell tumors. These tumors have high morbidity and mortality

bone marrow procedure
avid
cancer chemotherapy
desmoplastic
kidney function tests
  • 0 views
  • 12 Mar, 2022
  • 1 location
Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

The primary objective of this phase 1 trial is to determine the maximum tolerated dose (MTD), food effect, safety and tolerability of oral ONC206 in patients with recurrent, primary CNS neoplasms.

MRI
cancer chemotherapy
anaplastic astrocytoma
nitrosourea
astrocytoma
  • 10 views
  • 12 Mar, 2022
  • 1 location
Symptom Management for YA Cancer Survivors

Symptom interference is common for survivors of young adult cancer (aged 18-39 at diagnosis) and impacts their abilities to achieve normative life goals (e.g., education, careers, independence, romantic/social relationships) as well as adhere to recommended follow-up care. Assistance with symptom management has been rated by young adult survivors as an …

germ cell tumors
primary cancer
endocrine cancers
cancer
  • 0 views
  • 16 Jun, 2022
  • 1 location