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Found 1021 clinical trials
Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors

children undergoing radiotherapy for localized brain tumors (low grade glioma, craniopharyngioma, ependymoma, or germ cell tumor) To estimate the rate of memantine medication adherence

memantine
human chorionic gonadotropin
brain tumor
low grade glioma
ependymoma
  • 34 views
  • 12 May, 2022
  • 1 location
A Study of Therapeutic Iobenguane (131-I) and Vorinostat for Recurrent or Progressive High-Risk Neuroblastoma Subjects (OPTIMUM)

The purpose of this study is to evaluate the efficacy and safety of 131I-MIBG in combination with Vorinostat in patients with Recurrent or Progressive neuroblastoma

platelet count
platelet transfusions
etoposide
high-risk neuroblastoma
growth factor
  • 58 views
  • 24 Mar, 2022
  • 16 locations
C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)

This study is for patients with high grade glioma (HGG) or diffuse intrinsic pontine glioma (DIPG) or medulloblastoma or another rare brain cancer that expresses GD2. Because there is no standard treatment at this time, patients are being asked to volunteer in a gene transfer research study using special immune …

malignant glioma
dipg
platelet count
dexamethasone
medulloblastoma
  • 1 views
  • 11 Mar, 2022
  • 1 location
  • 0 views
  • 16 Jun, 2022
  • 1 location
Cetuximab for the Treatment of Advanced Unresectable or Metastatic Chordoma

This is a multicenter, single arm, phase 2 study designed to evaluate the efficacy and safety of cetuximab for the treatment of advanced (unresectable)/metastatic, chordoma. The target patient population will be any chordoma patient 18 years of age with locally unresectable disease or metastatic disease.

pet/ct
renal function
x-rays
ct scan
measurable disease
  • 0 views
  • 18 Jun, 2022
  • 1 location
Clinical Study of an Dendritic and Glioma Cells Fusion Vaccine With IL-12 for Treatment-na ve GBM Patients.

A multi-center, open-label, single-arm, phase I/II clinical study is designed to test the safety and immunogenicity of an investigational Dendritic and Glioma Cells Fusion vaccine given with IL-12 for treatment-nave patients after resection of glioblastoma.

ejection fraction
mg++
glioblastoma multiforme
cancer chemotherapy
temozolomide
  • 57 views
  • 24 Jan, 2021
  • 2 locations
Olanzapine Combined With Fosaprepitant, Ondansetron, and Dexamethasone for Preventing Nausea and Vomiting in Patients With Testicular Cancer

dexamethasone in the prevention of nausea and vomiting in germ-cell tumors receiving 5-day cisplatin chemotherapy

  • 0 views
  • 26 Mar, 2022
  • 1 location
Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies (NYMC195)

Investigators are testing new experimental drug combinations such as the combination of vorinostat, vincristine, irinotecan, and temozolomide in the hopes of finding a drug that may be effective against tumors that have come back or that have not responded to standard therapy. The goals of this study are: To find …

platelet count
chemotherapeutic agents
growth factor
biologic agent
irinotecan
  • 3 views
  • 01 Mar, 2022
  • 1 location
A Phase I Study of Lyso-thermosensitive Liposomal Doxorubicin and MR-HIFU for Pediatric Refractory Solid Tumors

, neuroblastoma, Wilms' tumor, hepatic tumors, and germ cell tumors.

platelet count
biological products
monoclonal antibodies
growth factor
myelosuppressive chemotherapy
  • 54 views
  • 25 Feb, 2022
  • 1 location
HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors

This is a Phase 1 study of central nervous system (CNS) locoregional adoptive therapy with autologous CD4 and CD8 T cells lentivirally transduced to express a HER2-specific chimeric antigen receptor (CAR) and EGFRt, delivered by an indwelling catheter in the tumor resection cavity or ventricular system in children and young …

cns neoplasm
viral therapy
tumour resection
cancer chemotherapy
tumor resection
  • 68 views
  • 17 Mar, 2022
  • 1 location