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Found 1022 clinical trials
CDK4/6 Inhibition in Locally Advanced/Metastatic Chordoma

In chordoma cell lines and patient biopsies, the p16 (CDKN2A) tumor suppressor is consistently deleted. Thus, chordomas are an example of a tumor with universal activation of the cyclin-dependent kinases 4 and 6 (CDK4/6) pathway, and experiments with patient-derived chordoma cell lines demonstrate aberrant CDK4/6 activity downstream of p16 loss …

vasectomy
sorafenib
hysterectomy
lapatinib
cancer chemotherapy
  • 39 views
  • 07 Jan, 2022
  • 3 locations
Pemetrexed for the Treatment of Chordoma

The purpose of this study is to test the safety and tolerability of pemetrexed administered to people with chordoma. Other purposes of this study are to: find out side effects (good and bad) of pemetrexed; learn more about how pemetrexed might affect the growth of cancer cells; evaluate tumor characteristics …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Accelerated v's Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours

The purpose of this study is to determine whether accelerated BEP chemotherapy is more effective than standard BEP chemotherapy in males with intermediate and poor-risk metastatic germ cell tumours.

renal function
alpha fetoprotein
testicular
metastasis
cancer chemotherapy
  • 80 views
  • 07 Dec, 2021
  • 28 locations
Disulfiram and Cisplatin in Refractory TGCTs. (DISGCT)

/refractory germ cell tumors (GCTs).

renal function
major surgery
alpha fetoprotein
metastasis
cancer chemotherapy
  • 15 views
  • 08 Feb, 2022
  • 1 location
A Phase II Trial of Cabozantinib With Patients With Refractory GCTs

The purpose of the CTO-IUSCCC-0752 study is to investigate the use of Cabozantinib for patients with incurable, refractory germ cell tumors. Patients will be treated until evidence of disease

alpha fetoprotein
cancer chemotherapy
human chorionic gonadotropin
seminoma
tumor markers
  • 1 views
  • 28 Jun, 2022
  • 1 location
Reduced Dose Radiotherapy Following High Dose Chemotherapy in Intracranial Non-germinomatous Germ Cell Tumor

The purpose of this study is to evaluate the outcome of intracranial non-germinomatous germ cell tumor (NGGCT) treated with reduced radiotherapy following high dose chemotherapy and autologous

  • 1 views
  • 25 Jan, 2021
  • 1 location
The Efficacy of WVI in Patients With Localized Basal Ganglia Intracranial Germ Cell Tumors

Primary endpoint three-year disease-free survival of patients with localized basal ganglia germ cell tumors receiving whole-ventricle irradiation Health-related quality

  • 0 views
  • 25 Nov, 2021
  • 1 location
TC or BEP in Treating Patients With Malignant Ovarian Germ Cell Tumors (MOGCT-01)

newly diagnosed malignant ovarian germ cell tumor patients after surgery.

carboplatin/paclitaxel
germ cell tumor
paclitaxel
carboplatin
etoposide
  • 24 views
  • 13 Feb, 2022
  • 1 location
A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

cell tumors (NGGCT) that have not spread to other parts of the brain or body (localized). This study has 2 goals: 1) optimizing radiation for patients who respond well to induction chemotherapy to

etoposide
immature teratoma
cancer
gonadotropin
tumor markers
  • 0 views
  • 27 Jun, 2022
  • 31 locations
Nivolumab and Relatlimab in Treating Participants With Advanced Chordoma

This phase II trial studies how well nivolumab and relatlimab work in treating participants with chordoma that has spread to other places in the body. Monoclonal antibodies, such as nivolumab and relatlimab, may interfere with the ability of tumor cells to grow and spread.

monoclonal antibodies
metastasis
vasectomy
nivolumab
human chorionic gonadotropin
  • 12 views
  • 15 May, 2022
  • 1 location