Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 1022 clinical trials
A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors

The main purpose of this study is to establish the safety and the recommended dose of TRK-950 in combination with FOLFIRI, Gemcitabine / Cisplatin, Gemcitabine / Carboplatin, Ramucirumab / Paclitaxel, PD1 inhibitors (Nivolumab or Pembrolizumab), and Imiquimod Cream, Bevacizumab, Gemcitabine / Carboplatin / Bevacizumab, Topotecan, and Pegylated liposomal doxorubicin (PLD) …

topotecan
ramucirumab
leucovorin
clear cell renal cell carcinoma
taxane
  • 20 views
  • 24 Apr, 2022
  • 13 locations
Selective TrkA Inhibitor VMD-928 to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

This is a multicenter, open-label, Phase 1 study of orally administered VMD-928 in adult subjects with advanced solid tumors or lymphoma that have progressed or are non responsive to available therapies and for which no standard or available curative therapy exists

lymphoma
solid tumour
thymoma
thymic carcinoma
prostate carcinoma
  • 84 views
  • 03 May, 2022
  • 7 locations
Integrated Cancer Repository for Cancer Research (iCaRe2)

The iCaRe2 is a multi-institutional resource created and maintained by the Fred & Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, high-risk individuals, and normal controls. The distinct characteristic of the iCaRe2 is its geographical coverage, with a significant …

primary cancer
Accepts healthy volunteers
early diagnosis
cancer
early detection
  • 1433 views
  • 13 Mar, 2022
  • 61 locations
A Study of XmAb®23104 in Subjects With Selected Advanced Solid Tumors (DUET-3) (DUET-3)

This is a Phase 1, multiple dose, ascending dose escalation study to define a MTD/RD and regimen of XmAb23104, to describe safety and tolerability, to assess PK and immunogenicity, and to preliminarily assess anti-tumor activity of XmAb23104 monotherapy and combination therapy with ipilimumab in subjects with selected advanced solid tumors.

erbb2
lung carcinoma
nasopharyngeal carcinoma
solid tumour
lung cancer
  • 139 views
  • 06 Feb, 2022
  • 13 locations
Safety and Efficacy of KY1044 and Atezolizumab in Advanced Cancer

A Phase 1/2, open label, multi-center study to evaluate the safety, efficacy and tolerability of KY1044 as single agent and in combination with anti-PD-L1 (atezolizumab) in adult patients with selected advanced malignancies, who are ineligible for or there are no available therapies known to confer a clinical benefit for their …

triple negative breast cancer
breast cancer
lung carcinoma
squamous cell carcinoma
carcinoma
  • 100 views
  • 09 Jun, 2022
  • 10 locations
Study of NGM438 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumors

Study of NGM438 as Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumors

pembrolizumab
  • 0 views
  • 13 Jun, 2022
  • 1 location
HMBD-001 in Advanced HER3 Positive Solid Tumours

This clinical trial is evaluating a drug called HMBD-001 (an anti-HER3 monoclonal antibody) in patients with advanced HER3 positive solid tumours. The main aims are to find out the maximum dose of HMBD-001 that can be given safely to patients alone and in combination with other anti-cancer agents, more about …

lung carcinoma
immunohistochemistry
lung cancer
cancer of the ovary
pancreatic cancers
  • 0 views
  • 20 Dec, 2021
  • 2 locations
Study of ADCT-301 in Patients With Selected Advanced Solid Tumors

This study evaluates ADCT-301 in patients with Selected Advanced Solid Tumors. Patients will participate in a Treatment Period with 3-week cycles and a Follow-up Period every 12 weeks for up to 1 year after treatment discontinuation.

lung carcinoma
platelet count
solid tumour
lung cancer
blood transfusion
  • 77 views
  • 27 Apr, 2022
  • 10 locations
Naptumomab Estafenatox in Combination With Durvalumab in Subjects With Selected Advanced or Metastatic Solid Tumors

This is a dose escalation, MTD expansion (Phase 1b) and cohort expansions (Phase 2) study to assess the safety and tolerability of a combination of NAP with durvalumab in subjects with selected advanced or metastatic solid tumors.

brain metastases
pancreatic adenocarcinoma
medi4736
denosumab
major surgery
  • 15 views
  • 16 Jun, 2022
  • 3 locations
Liquid Biopsy Evaluation and Repository Development at Princess Margaret (LIBERATE)

The objective of this protocol is to develop an institution-wide liquid biopsy protocol that will establish a common process for collecting blood and corresponding archived tumor specimens for future research studies at the University Health Network's Princess Margaret Cancer Centre. Circulating cell-free nucleic acids (cfNA), including cell-free DNA (cfDNA) and …

solid tumor
cancer treatment
cancer
tumor progression
primary cancer
  • 171 views
  • 05 May, 2022
  • 1 location