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Found 316 clinical trials
Family History and Cancer Risk Study (FOREST)

Investigators from Vanderbilt University Medical Center (VUMC), Duke University, and Meharry Medical College (MMC) are collaborating on a family health history study to deploy a family health history (FHH) platform, MeTree. Recruited participants will complete surveys, the MeTree questionnaire, and MeTree will determine the participant's cancer risk based on current …

Accepts healthy volunteers
  • 06 Apr, 2022
  • 1 location
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU001 (DIAN-TU)

The purpose of this study is to assess the safety, tolerability, biomarker and cognitive efficacy of investigational products in subjects who are known to have an Alzheimer's disease-causing mutation by determining if treatment with the study drug slows the rate of progression of cognitive impairment and improves disease-related biomarkers.

alzheimer's disease
mild cognitive impairment
mild dementia
Accepts healthy volunteers
  • 30 Jan, 2022
  • 28 locations
Genetic Testing for All Breast Cancer Patients (GET FACTS)

This study is designed to determine the impact of a novel genetic counseling method on surgical decisions in individuals with newly diagnosed breast cancer This research study involves an expedited and surgery-specific form of genetic counseling. The names of the study methods involved in this trial are/is: Quantitative genetic counseling …

breast carcinoma
  • 02 Mar, 2022
Clinical Application of Non-invasive PGT-A

The study aims to investigate the difference of in vitro fertilization (IVF) outcomes among non-invasive PGT-A, PGT-A and combined non-invasive PGT-A and PGT-A.

  • 29 Apr, 2021
  • 1 location
Development and Implementation of Electronic Decision Aids for Genetic Testing in Inherited Cancer Syndromes

genetic testing and which specific multi-gene panel to pursue. A survey will then be administered to assess participants' opinions on the decision aid.

  • 25 Mar, 2022
  • 1 location
Impact of a Mobile App on Pregnant Women's Prenatal Genetic Testing Decision-making

Determine the effect of a culturally sensitive prenatal genetic testing (PGT) education intervention delivered via a mobile application on pregnant women's perceptions, knowledge, and uptake of

  • 07 Oct, 2021
  • 1 location
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions

Pulmonary arterial hypertension (PAH) in patients with congenital heart disease (CHD) is associated with considerable morbidity and even mortality. Next to environmental risk factors, the investigators believe that there is an important role of genetic predisposition to develop PAH in CHD. There often is a discrepancy between the severity of …

heart disease
right heart catheterization
ventricular septal defect
vascular disease
septal defect
  • 04 Jun, 2022
  • 1 location
Genetic Testing and Motivational Counseling for FH

prescription as early as possible, better in childhood. The aim of the study is to assess the impact of genetic testing and motivational counseling on the effectiveness of treatment and cascade screening in

lipid-lowering therapy
cholesterol level
  • 01 Nov, 2021
  • 1 location
APOL1 Genetic Testing Program for Living Donors

consent. Given their elevated risk of ESRD post-donation, and AAs' widely-held cultural concerns about genetic testing, it is ethically critical to protect AA LD candidates' safety through APOL1 testing

end-stage renal disease
  • 29 Nov, 2021
  • 2 locations
Effectiveness of MyCancerGene to Optimize Genetic Testing Outcomes (MyCancerGene)

, and affective and behavioral responses to genetic testing. The study investigators hypothesize that the intervention will be associated with increases in knowledge, decreases in distress, increases in

genetic testing
Accepts healthy volunteers
primary cancer
  • 06 Apr, 2022
  • 1 location