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Found 316 clinical trials
A Diagnosis and Treatment Optimization Study of Depression Based on the Neurological Mechanism of Reward System

studies of MDD. We would collect MDD patients with melancholic features and other populations with reward dysfunction. The neuroimaging techniques, stress assessment, genetic testing and drug intervention

Accepts healthy volunteers
  • 20 Feb, 2022
  • 1 location
CMV IGG Antibodies in Semen as a Predictor for Blood Testis Barrier Damage

To assess whether the presence of Cytomegalovirus (CMV) Immunoglobulin G (IGG) antibodies in semen is a reliable predictor of male subfertility or infertility.

Accepts healthy volunteers
  • 19 Apr, 2022
  • 1 location
Epileptiform Activity During REM Sleep in Alzheimer's Disease (EREMAD)

Recent clinical data showed that patients with Alzheimer Disease (AD) might present epilepsy at early stages of the disease (Cretin et al., 2016, Vossel et al., 2016). In mice models of Alzheimer disease, preclinical researchers observed an increase of epileptic events during Rapid Eye Movement (REM) sleep, which is very …

mini-mental state examination
Accepts healthy volunteers
apolipoprotein e
mental state examination
  • 23 Jan, 2022
  • 1 location
A Study of CHeckpoint Inhibitors in Men With prOgressive Metastatic Castrate Resistant Prostate Cancer Characterized by a Mismatch Repair Deficiency or Biallelic CDK12 Inactivation (CHOMP)

The primary objective is to assess the activity and efficacy of pembrolizumab, a checkpoint inhibitor, in Veterans with metastatic castration-resistant prostate cancer (mCRPC) characterized by either mismatch repair deficiency (dMMR) or biallelic inactivation of CDK12 (CDK12-/-). The secondary objectives involve determining the frequency with which dMMR and CDK12-/- occur in …

  • 18 Feb, 2022
  • 8 locations
Family History and Breast Cancer Education Trial

The overall goal of this study is to reduce breast cancer morbidity and mortality disparities among African American women by actively engaging family history as a tool to modify screening regimens and enhance communication between women and their providers. Therefore, this rationale is reflected the project title: "You cannot change …

Accepts healthy volunteers
  • 25 Mar, 2022
  • 1 location
Study of Pembrolizumab in Metastatic HER2-negative Breast Cancer Patients With APOBEC3B Mutation

This is an open label investigator initiated Phase II study of single agent pembrolizumab (Keytruda) in metastatic HER2-receptive negative breast cancer patients with germline deletion in the cytosine deaminase (APOBEC3B) gene. Approximately 44 subjects from Malaysia and Singapore will be enrolled in this study to examine the efficacy of pembrolizumab …

hormone therapy
endocrine therapy
  • 25 Jan, 2021
  • 2 locations
PRIME Care (PRecision Medicine In MEntal Health Care) 2.0

Background: In the last several years, commercial pharmacogenetic (PGx) testing for the selection of psychotropic medications has become widespread as a means of implementing "precision medicine", with some insurers electing to cover the cost of testing. Mostly these efforts have focused on the decision of choosing a medication. Polypharmacy has …

  • 21 Jul, 2021
  • 1 location
Engaging Adolescents in Decisions About Return of Genomic Research Results

Recent recommendations to return children's results for adult-onset conditions to parents anytime whole exome or genome sequencing is performed, as well as growing expectations to return research results to participants on a large-scale basis, mean adolescents will increasingly be engaged in assenting (<age 18) and consenting (>age 18) to return …

Accepts healthy volunteers
  • 12 Mar, 2022
  • 1 location
OPTimizing Treatment Focused Genetic Testing IN Cancer (OPT-IN)

This two-part randomized controlled trial aims to evaluate the impact of pre-test video education as compared to pre-test Chatbot education.

  • 02 May, 2022
  • 1 location
Genetic Testing in Young Adults With Cancer Study

The overarching goal of our research is to define an evidence-based, sustainable approach to identifying and managing genetic risk among young adults with cancer and their relatives. Conventional practice leaves referral and testing decisions to mostly non-expert clinicians implementing complex guidelines at the point of care, leading to substantial under-utilization. …

solid tumor
primary cancer
cancer diagnosis
genetic testing
  • 20 Oct, 2021
  • 1 location