Found 250 clinical trials
Improved Diagnosis of Familial Hypercholesterolemia Across the Northland (ID-FH) (ID-FH)
The overall goal of this study is to promote awareness of Familial Hypercholesterolemia (FH). The investigators aim to enroll patients with suspected FH into the study and will randomize them to receive usual care or motivational interview. Primary study outcomes include knowledge of FH, as well as clinical and patient-reported …
- 0 views
- 08 Mar, 2022
- 2 locations
UZ/KU Leuven Program for Post-mortem Tissue Donation to Enhance Research
UPTIDER is a prospective, interventional, non-Investigational Medicinal Product (non-IMP), non-commercial, single centre post-mortem tissue donation program for metastatic breast cancer patients or patients with a germline pathogenic variant with a moderate to high lifetime risk of breast cancer and at least one malignancy at time of death. The overarching objective …
- 0 views
- 08 Apr, 2021
- 1 location
Rifampin in CYP24A1-related Hypercalcemia and Hypercalciuria (RICHH)
This study evaluates the efficacy of rifampin in the treatment of hypercalcemia and/or hypercalciuria in participants with biallelic inactivating mutations of the CYP24A1 gene. Eligible subjects will receive rifampin for a total of 16 weeks during this study.
- 57 views
- 10 Mar, 2022
- 1 location
Grand Valley State University (GVSU) Skills on Wheels
Manual wheelchairs (MWCs) are widely used by children with physical disabilities, yet many of these children are unable to use their wheelchair independently. Instead, they depend on others to push them. This dependency results in limited opportunities to decide what they want to do and where they want to go, …
- 0 views
- 29 May, 2022
- 1 location
Implementing an Individualized Pain Plan (IPP) for ED Treatment of VOE's in Sickle Cell Disease (ALIGN)
The overall purpose of this proposed study is to improve management of vaso-occlusive episodes (VOEs) in adult EDs. We aim to implement NHLBI recommendations for VOE treatment by embedding Individualized Pain Plans (IPPs) in the electronic health record (EHR). The EHR-embedded IPP will serve as a record of patients' SCD …
- 10 views
- 20 Apr, 2022
- 8 locations
Efficacy of Aponeurectomy on the 2-year Recurrence Rate of Dupuytren's Disease (REMEDY)
Dupuytren's disease is a frequent hereditary disease in Northern Europe. It is a degenerative disease affecting the palmar aponeurosis of the hand. It develops a progressive contractile fibrosis
- 9 views
- 26 Aug, 2023
- 1 location
Theophylline Treatment for Pseudohypoparathyroidism
Pseudohypoparathyroidism is a genetic disorder with limited treatment options. Patients have early-onset obesity, short stature and increased risk of type 2 diabetes. This phase 2 clinical trial
- 54 views
- 29 Aug, 2023
- 1 location
Phase 2 Study of Theophylline Treatment for Pseudohypoparathyroidism
Pseudohypoparathyroidism is a genetic disorder with limited treatment options, characterized by early-onset obesity, short stature and resistance to multiple hormones. This phase 2 clinical
- 0 views
- 23 Oct, 2022
- 1 location
A Safety and Pharmacokinetics Trial of VO659 in SCA1, SCA3 and HD
The goal of this first-in-human clinical trial is to assess the safety and tolerability of four doses of a new study drug called VO659 in people with genetic disorders called spinocerebellar
- 0 views
- 29 Aug, 2023
- 2 locations
SEQUence of Endocrine Therapy in Advanced Luminal Breast Cancer (SEQUEL-Breast) (SEQUEL-Breast)
The study is a nationwide, multicenter single-arm phase 2 study. The current phase 2 study investigates the efficacy of the combination of fulvestrant and alpelisib directly after progression on fulvestrant (either in first or second line, with or without previous use of CDK4/6-inhibitor) in patients with HR+ HER2- advanced breast …
- 0 views
- 08 Apr, 2023
- 20 locations