Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 297 clinical trials
Improved Diagnosis of Familial Hypercholesterolemia Across the Northland (ID-FH) (ID-FH)

The overall goal of this study is to promote awareness of Familial Hypercholesterolemia (FH). The investigators aim to enroll patients with suspected FH into the study and will randomize them to receive usual care or motivational interview. Primary study outcomes include knowledge of FH, as well as clinical and patient-reported …

Accepts healthy volunteers
cholesterol level
  • 0 views
  • 08 Mar, 2022
  • 2 locations
Rifampin in CYP24A1-related Hypercalcemia and Hypercalciuria (RICHH)

This study evaluates the efficacy of rifampin in the treatment of hypercalcemia and/or hypercalciuria in participants with biallelic inactivating mutations of the CYP24A1 gene. Eligible subjects will receive rifampin for a total of 16 weeks during this study.

rifampin
calcium
  • 57 views
  • 10 Mar, 2022
  • 1 location
UZ/KU Leuven Program for Post-mortem Tissue Donation to Enhance Research

UPTIDER is a prospective, interventional, non-Investigational Medicinal Product (non-IMP), non-commercial, single centre post-mortem tissue donation program for metastatic breast cancer patients or patients with a germline pathogenic variant with a moderate to high lifetime risk of breast cancer and at least one malignancy at time of death. The overarching objective …

  • 0 views
  • 08 Apr, 2021
  • 1 location
Effects of Sitagliptin in Individuals With Genetically Decreased DPP4

This is a pilot clinical trial to test the hypothesis that during sitagliptin (DPP4 inhibitor), individuals heterozygous for DPP4 loss of function variants will have a reduction in DPP4 activity and antigen, lower glucose after a mixed meal, and higher levels of intact DPP4 substrates compared to during placebo and …

sitagliptin 100 mg
renal function
diabetes
hypertension
  • 0 views
  • 25 Mar, 2022
  • 1 location
Pediatric Powered Wheelchair Standing Devices: An Exploratory Study

For children who use a power wheelchair, a powered wheelchair standing device (PWSD) may be considered for daily use. A PWSD allows a child to electronically move between sitting and standing and can be driven in either position. Existing published PWSD research in pediatrics is limited to boys with Duchenne …

muscular dystrophy
  • 0 views
  • 30 May, 2022
  • 1 location
Grand Valley State University (GVSU) Skills on Wheels

Manual wheelchairs (MWCs) are widely used by children with physical disabilities, yet many of these children are unable to use their wheelchair independently. Instead, they depend on others to push them. This dependency results in limited opportunities to decide what they want to do and where they want to go, …

injuries
  • 0 views
  • 29 May, 2022
  • 1 location
Implementing an Individualized Pain Plan (IPP) for ED Treatment of VOE's in Sickle Cell Disease (ALIGN)

The overall purpose of this proposed study is to improve management of vaso-occlusive episodes (VOEs) in adult EDs. We aim to implement NHLBI recommendations for VOE treatment by embedding Individualized Pain Plans (IPPs) in the electronic health record (EHR). The EHR-embedded IPP will serve as a record of patients' SCD …

opioid
Accepts healthy volunteers
  • 0 views
  • 20 Apr, 2022
  • 8 locations
Genomic Medicine for Ill Neonates and Infants (The GEMINI Study) (GEMINI)

a targeted genomic sequencing panel on neonates and infants suspected of having a genetic disorder. This study is funded by the National Institutes of Health. This multicenter, prospective

  • 0 views
  • 11 Feb, 2022
  • 6 locations
SEQUence of Endocrine Therapy in Advanced Luminal Breast Cancer (SEQUEL-Breast) (SEQUEL-Breast)

The study is a nationwide, multicenter single-arm phase 2 study. The current phase 2 study investigates the efficacy of the combination of fulvestrant and alpelisib directly after progression on fulvestrant (either in first or second line, with or without previous use of CDK4/6-inhibitor) in patients with HR+ HER2- advanced breast …

advanced breast cancer
HER2
hormone therapy
estrogen receptor
progesterone receptor
  • 0 views
  • 30 Jun, 2022
  • 8 locations
Theophylline Treatment for Pseudohypoparathyroidism

Pseudohypoparathyroidism is a genetic disorder with limited treatment options. Patients have early-onset obesity, short stature and increased risk of type 2 diabetes. This phase 2 clinical trial

diabetes
  • 51 views
  • 04 Mar, 2022
  • 1 location