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Found 578 clinical trials
Neuroinflammation and Alzheimer's Pathology in POCD (POCD)

The purpose of this project is to investigate the role of both neural inflammation and pre-existing neurodegenerative pathology in the risk and pathogenesis of post-operative cognitive dysfunction (POCD). To achieve this goal, the investigators will combine blood and cerebrospinal fluid (CSF) sampling, standardized cognitive tests, and dynamic neurophysiological markers of …

cognitive assessment
Accepts healthy volunteers
  • 29 May, 2022
  • 1 location
ASSESSment of Perfusion Oxygen Saturation Endothelial Function and Coagulation in Circulatory SHOCK

The objective of the observational cohort study is (1) to deduce whether measurements of peripheral near-infrared spectroscopy (NIRS) (lower limb) associate with the development of organ dysfunction as assessed by daily Sequential Orfgan Failure Score (SOFA) in the Intensive Care Unit (ICU), (2)whether cerebral (frontal) tissue haemoglobin oxygen saturation (StO2) …

  • 29 Aug, 2021
  • 3 locations
Microbiota Implementation to Reduce Anastomotic Colorectal Leaks (MIRACLe)

Aim of this study is to implement the intestinal microbiota by perioperative administration of probiotics, oral antibiotics and low volume mechanical preparation in order to reduce the incidence of colorectal anastomotic leaks and dehiscences.

Accepts healthy volunteers
  • 01 Jan, 2022
  • 1 location
Prognostic Value of Lung Ultrasound in Predicting Intensive Care Unit Length of Stay in Adult Cardiac Surgery

Being easy, bedside, non-expensive, noninvasive and radiation free, there has been a growing interest in the implementation of lung ultrasound in critical care management in the last decade, cardiac surgery was not an exception in both adult and pediatric surgeries Many predictors for open heart surgery outcomes have been studied …

heart surgery
bypass graft
cardiopulmonary bypass
  • 08 Oct, 2021
  • 1 location
'Understanding the Electrophysiological Substrate Underlying Persistent Atrial Fibrillation Study II (USURP AF- Study II)' (USURPAF)

Atrial fibrillation (AF) is the most common type of chronic heart rhythm disease worldwide, with significant associated co-morbidities. Although there have been advances in understanding the mechanisms of AF, the underlying cause of AF and factors which perpetuate it remain incompletely understood. This is particularly the case for persistent AF …

catheter ablation
pulmonary vein isolation
persistent atrial fibrillation
  • 14 Feb, 2022
  • 1 location
Bariatric Endoscopy for Treatment of Obesity

A single-center prospective, randomized controlled study will be conducted in order to compare the main bariatric endoscopy (BE) techniques in I and II grade obese patients (BMI >30 kg/m2) at Gastroenterology and Gastrointestinal Endoscopy Unit, Mater Olbia Hospital, Qatar Foundation Endowment & Gemelli Foundation, Italy in period June 2020 - …

  • 15 Jun, 2022
  • 1 location
Evaluation of Nidus Occlusion After Gamma Knife Radiosurgery of Cerebral Arteriovenous Malformations Using Magnetic Resonance Imaging

Cerebral arteriovenous malformations (AVMs) are abnormal vessels, connecting cerebral arteries and veins. They form a bundle which is called nidus. Rupture of an AVM leads to intracranial hemorrhage often causing neurological impairment or even death. As treatment can be associated with high rates of morbidity and mortality, AVMs still remain …

gamma knife radiosurgery
intracranial hemorrhage
  • 12 Feb, 2022
  • 1 location
Liquid Biopsy for ctDNA in Peritoneal Lavage and Blood in Pancreatic Cancer (LIPAC)

Pancreatic cancer (PC) is a deadly disease and surgical resection of the tumor is the only hope of cure. Approximately 20-25% of the PC patients are candidates for intended curative resection, but despite microscopically radical resection the majority of patients will have recurrent disease within 2 years. This indicates that …

tumor cells
pancreatic resection
  • 16 Jun, 2022
  • 1 location