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Found 577 clinical trials
Featured trial
A Randomized Controlled Trial of Regional versus General Anesthesia for Promoting Independence after Hip Fracture (REGAIN Trial)

A Randomized Controlled Trial of Regional versus General Anesthesia for Promoting Independence after Hip Fracture (REGAIN Trial)

  • 23 Nov, 2020
  • 1 location
Featured trial
Phase 1 Study To Assess the Safety and Tolerability of Human Embryonic Stem Cell-Derived Midbrain Dopamine Neuron Cell Therapy (MSK-DA01) For Advanced Parkinson's Disease

Dopamine neurons made from stem cells are injected into the brain under general anesthesia. Subjects then take medicines to partially suppress their immune system (aimed to prevent the body from

  • 18 Apr, 2022
  • 2 locations
Driving Pressure During General Anesthesia for Open Abdominal Surgery (DESIGNATION)

The purpose of this international multicenter, patient and outcome-assessor blinded randomized controlled trial is to determine whether the application of an individualized high PEEP strategy, aiming at avoiding an increase in the driving pressure during intraoperative ventilation, protects against the development of postoperative pulmonary complications.

  • 11 Mar, 2022
  • 19 locations
Ultrasound Guided Peripheral Venous Cannulation in Patient Undergoing Elective Surgery Under General Anesthesia.

This study evaluates two different techniques for peripheral venous cannulation in operating theatre. Ultrasound guided insertion of peripheral cannula in comparison with conventional approach without any ultrasound guidance.

Accepts healthy volunteers
  • 29 Nov, 2021
  • 1 location
Cardiovascular Protection Conservative Effects of Esketamine Versus µ-opioid Receptor Agonists in General Anesthesia

, regardless of the gender) undergoing surgery under total intravenous general anesthesia with conventional µ-opioid agonists or Esketamine, as the major analgesic. Clinically appropriate anesthesia depth or

  • 02 May, 2022
  • 1 location
First Attempt Intubation Rate With Airtraq vs Macintosh Direct Laryngoscope (FAIRAiM)

the Macintosh direct laryngoscope in patients requiring general anesthesia for elective operation, with the aims to examine the feasibility of a large multicentre effectiveness trial by assessing

endotracheal intubation
  • 17 Feb, 2022
Effect of Electroacupuncture on the Incidence of Postoperative Delirium in Elderly Patients Undergoing the Major Surgery

tumor surgery, bile duct surgery, thoracic surgery or orthopedic surgery and so on under general anesthesia, and the estimated operation time≥ 2 hours. Sample size: Enroll 1700 patients (850

major surgery
orthopedic surgery
mechanical ventilation
postoperative complication
  • 11 Mar, 2022
  • 1 location
A Randomised Trial of S-ICD Implantation With and Without Defibrillation Testing (PRAETORIAN-DFT)

This study will test the hypothesis that implantation of a subcutaneous implantable cardioverter defibrillator (S-ICD) without performing a defibrillation test is non-inferior to S-ICD implant with a defibrillation test with regards to the primary endpoint failed first shock in a spontaneous arrhythmia episode when implant position is confirmed with PRAETORIAN …

  • 03 Mar, 2022
  • 32 locations
EEG Guidance of Anesthesia (ENGAGES-CANADA) (ENGAGES)

This study examines the potential link between deep levels of anesthesia and delirium.

  • 24 Feb, 2022
Effect of Intravenous S-ketamine on Opioid Consumption

Female patients with an American Society of Anesthesia (ASA) physical status I-II, scheduled for elective breast cancer surgery will be included in the study. Subjects will be randomly assigned to one of three groups: the placebo group, the low-dose S-ketamine group, and the high-dose S-ketamine group. The primary outcome is …

  • 25 Mar, 2022
  • 1 location