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Found 2480 clinical trials
Assessing Durvalumab and FLOT Chemotherapy in Resectable Gastric and Gastroesophageal Junction Cancer

This is a Global Study of Neoadjuvant-Adjuvant Durvalumab or Placebo and FLOT Chemotherapy Followed by Adjuvant Durvalumab or Placebo in Patients with Resectable Gastric and Gastroesophageal Cancer (GC/GEJC) (MATTERHORN).

monoclonal antibodies
oxaliplatin
immunoglobulin
adenocarcinoma
cancer
  • 16 views
  • 19 Apr, 2022
  • 136 locations
Interaction Between Host, Microenvironment and Immunity on Gastrointestinal Neoplasms (HoMING)

The primary objective: association study of characteristics of tumoral microenvironment and immunity of digestive cancers with patients' overall survival (OS).

mirna
  • 0 views
  • 10 Mar, 2022
FOLFIRINOX vs FLOT Chemotherapy for Resectable Gastric or Esophagogastric Junction Adenocarcinoma

Patients with resectable adenocarcinoma of the stomach or the esophagogastric junction (II-III type by Siewert) without previous therapy will be treated with one of two chemotherapy combinations before and after surgery. One half of the patients gets 5-Fluorouracil (5-FU), Leucovorin, Oxaliplatin and Docetaxel (FLOT), the others 5-Fluorouracil (5-FU), Leucovorin, Oxaliplatin …

oxaliplatin
gastric adenocarcinoma
irinotecan
metastasis
leucovorin
  • 9 views
  • 22 Apr, 2021
  • 1 location
A Study to Find a Safe and Effective Dose of BI 905711 in Patients With Advanced Gastrointestinal Cancer

Phase Ia - Explore safety and establish the maximum tolerated dose (MTD)/recommended dose levels for phase Ib expansion phase of BI 905711 based on the frequency of patients experiencing dose limiting toxicities (DLTs) during the MTD evaluation period. The MTD evaluation period is defined as the first two treatment cycles …

carcinoma
gastric adenocarcinoma
colorectal adenocarcinoma
pancreatic adenocarcinoma
metastasis
  • 76 views
  • 09 May, 2022
  • 9 locations
Effect of 35624 Alflorex in Functional Gastrointestinal Disorders (FGIDs) in Children.

Syndrome Gastrointestinal Symptom Rating Scale (IBS-GSRS) and validated Numeric Pain Rating Scale (NRS-II) in children with Functional Gastrointestinal Disorders (FGIDs).

constipation
dyspepsia
  • 0 views
  • 12 Sep, 2021
  • 1 location
Domperidone in Treating Patients With Gastrointestinal Disorders

This phase III trial studies how well domperidone works in treating patients with gastrointestinal disorders. Domperidone may help control chronic gastrointestinal disorders and their symptoms

respiratory symptoms
gastrointestinal disorder
gastroparesis
gastrointestinal disease
nausea
  • 1561 views
  • 12 May, 2022
  • 1 location
MTT for Children With ASD Who Have Gastrointestinal Disorders

The investigators propose to investigate Microbiota Transfer Therapy (MTT) for treating children with Autism Spectrum Disorder (ASD) and gastrointestinal problems (primarily constipation and/or diarrhea). MTT involves a combination of 10 days of oral vancomycin (an antibiotic to kill pathogenic bacteria), followed by a bowel cleanse, followed by 12 weeks of …

microbiota
antibiotic therapy
gastrointestinal disorder
pervasive developmental disorder
constipation
  • 18 views
  • 20 Feb, 2022
  • 1 location
Behavioral Therapy in Patients With Rumination

questionnaire for adult functional gastrointestinal diseases at onset and at the 6-month control. Health-related quality of life, depression, anxiety, functional capacity will be evaluated by specific

anxiety
  • 0 views
  • 11 Mar, 2022
  • 1 location
Effects of Imagery Therapy vs Progressive Muscle Relaxation Therapy on Patients With Functional Abdominal Bloating

65% of the general population reported experiencing moderate to severe bloating symptoms. Bloating could be disturbing to patients and frustrating to the physicians as an effective treatment is still lacking. Guided Imagery (GI) involves the structured visualisation of mental images with somatic sensory; whereas Progressive Muscle Relaxation (PMR) focuses on …

bloating
discomfort
  • 0 views
  • 30 Sep, 2021
  • 1 location
The Treatment of Acute Gastrointestinal Injury Via Ultrasound-guided Erector Spinae Plane Block

In this single-center, randomized, parallel control clinical trial, patients will be randomly assigned to two groups. The treatment group receives ultrasound-guided erector spinae plane block with routine treatment of Acute Gastrointestinal Injury (AGI) for 7 days or until transferred to the general ward, while the control group only receives routine …

  • 0 views
  • 18 May, 2022
  • 1 location