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Found 2511 clinical trials
HMBD-001 in Advanced HER3 Positive Solid Tumours

This clinical trial is evaluating a drug called HMBD-001 (an anti-HER3 monoclonal antibody) in patients with advanced HER3 positive solid tumours. The main aims are to find out the maximum dose of HMBD-001 that can be given safely to patients alone and in combination with other anti-cancer agents, more about …

cancer of the ovary
lung carcinoma
monoclonal antibodies
bladder tumor
  • 20 Dec, 2021
  • 2 locations
CPI-006 Alone and in Combination With Ciforadenant and With Pembrolizumab for Patients With Advanced Cancers

This is a Phase 1/1b open-label, dose escalation and dose expansion study of CPI-006, a humanized monoclonal antibody (mAb) targeting the CD73 cell-surface ectonucleotidase in adult subjects with select advanced cancers. CPI-006 will be evaluated as a single agent, in combination with ciforadenant (an oral adenosine 2A receptor antagonist), in …

measurable disease
solid tumour
bladder cancer
lung cancer
breast cancer
  • 28 Apr, 2022
  • 23 locations
A First-in-Human JAB-8263 in Adult Patients With Advanced Tumors

This is a Phase 1/2a, first-in-human, open-label study of JAB-8263, this study has two parts: solid tumor dose escalation and expansion study and hematology tumor dose escalation and expansion study. These two parts will determine the maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D) and assess the DLT of …

measurable disease
solid tumor
refractory acute myeloid leukemia (aml)
  • 03 Aug, 2021
  • 1 location
Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer the RESTORE Study

This trial studies how well sacral nerve stimulation works in treating low anterior resection syndrome or fecal incontinence (the body's passage of stool without control) in patients with rectal cancer that has spread to nearby tissues or lymph nodes, or other pelvic cancer. Sacral nerve stimulation is a permanent implant …

  • 23 Jan, 2021
  • 2 locations
Antibiotic Prophylaxis in Patients Undergoing GVO (ABX-GV)

We design a randomized trial to clarify the necessity of antibiotic prophylaxis for the patients chronic liver disease with gastric varices treated by elective GVO.

liver disease
antibiotic therapy
gastric varices
  • 16 Feb, 2022
Australian and New Zealand Massive Transfusion Registry (ANZ-MTR)

Severe and un-stopped blood loss can occur for a number of different reasons including after a serious injury, delivery of a baby and following other medical and surgical emergencies. The investigators understanding of how to best treat people with serious bleeding is still incomplete, with many questions remaining. These include …

blood component
blood transfusion
  • 27 Jan, 2022
  • 1 location
General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care Delivery (PLEDGE)

In partnership with Helmsley Charitable Trust, the Sanford PLEDGE Study is a large-scale, observational, feasibility study of general population screening for T1D and celiac autoantibodies. Screening is incorporated into routine health care visits within an integrated health system.

Accepts healthy volunteers
celiac disease
  • 22 Mar, 2022
  • 3 locations
Optimization of Transcutaneous Electrical Acustimulation Modalities for Treatment of IBS-C

This study aims to determine the most effective treatment with Transcutaneous Electrical Acustimulation (TEA) for Irritable Bowel Syndrome with Constipation (IBS-C) by comparing efficacy between 5 separate sessions. The rectum pressure as measured by a device called a barostat will be compared between visits. Each session will be testing a …

abdominal pain
irritable bowel syndrome
  • 10 Oct, 2021
  • 1 location
Evaluation of Different Smoking Cessation Protocols: Nicotine Replacement Motivational Interviewing (MI) Cognitive Behavioural Therapy (CBT) or Hypnotherapy in Cancer Patients Scheduled for Surgery

This trial offers support and assistance to patients wishing to quit smoking in order to increase the success rate of smoking cessation and all the benefits associated with it. Patients will be monitored by a tobacco specialist and will be able to benefit from one or more therapies complementary to …

  • 03 Nov, 2021
  • 1 location
Acoustic Cough Monitoring for the Management of Patients With Known Respiratory Disease

This study pretends to evaluate the potential use of Hyfe Cough Tracker (Hyfe) to screen for, diagnose, and support the clinical management of patients with respiratory diseases, while enriching a dataset of disease-specific annotated coughs, for further refinement of similar systems.

Accepts healthy volunteers
  • 17 Nov, 2021
  • 1 location