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Found 720 clinical trials
A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers (HERIZON-GEA-01)

patients in this study will have advanced human epidermal growth factor 2 (HER2)-positive stomach and esophageal cancers that are no longer treatable with surgery (unresectable) or chemoradiation, and/or

adenocarcinoma
trastuzumab
capecitabine
oxaliplatin
erbb2
  • 0 views
  • 11 Aug, 2022
  • 149 locations
FOLFIRINOX vs FLOT Chemotherapy for Resectable Gastric or Esophagogastric Junction Adenocarcinoma

Patients with resectable adenocarcinoma of the stomach or the esophagogastric junction (II-III type by Siewert) without previous therapy will be treated with one of two chemotherapy combinations

adenocarcinoma
combinations
irinotecan
gastric adenocarcinoma
leucovorin
  • 9 views
  • 22 Apr, 2021
  • 1 location
Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial (REVISE)

Patients who are critically ill in the in the Intensive Care Unit (ICU), especially those who need a breathing machine, can develop ulcers in the stomach that bleed. To prevent bleeding, many

resuscitation
  • 509 views
  • 11 Mar, 2022
  • 53 locations
The AUDACITY Study (AllUrion Device in Adults With Clinical ObesITY) (AUDACITY)

, indwell time of the AGBS inside the stomach, and outcomes at 48 weeks.

Accepts healthy volunteers
  • 49 views
  • 16 Jun, 2022
  • 2 locations
Multicentric Randomized Study of H. Pylori Eradication and Pepsinogen Testing for Prevention of Gastric Cancer Mortality (GISTAR)

Currently no ideal preventive modalities are available for reducing gastric-cancer caused mortality in organized population-based application. The primary objective of the study is to determine if H.pylori screening followed by eradication of positive subjects and endoscopic follow-up of those with serological evidence of atrophic gastritis reduces mortality from gastric cancer …

Accepts healthy volunteers
gastric cancer
gastritis
endoscopy
cancer
  • 21 views
  • 23 Feb, 2022
  • 1 location
A Study to Assess the Antitumor Activity, Safety, Pharmacokinetics and Biomarkers of Zolbetuximab (IMAB362) in Participants With Claudin (CLDN) 18.2 Positive, Metastatic or Advanced Unresectable Gastric and Gastroesophageal Junction (GEJ) Adenocarcinoma (ILUSTRO)

The purpose of this study is to determine the Objective Response Rate (ORR) of zolbetuzimab as a single agent as assessed by an independent central reader. This study will also assess the ORR and Progression Free Survival (PFS) of zolbetuximab in combination with mFOLFOX6 (with or without Nivolumab) and in …

adenocarcinoma
human epidermal growth factor
adjuvant chemotherapy
leucovorin
measurable disease
  • 131 views
  • 29 Jul, 2022
  • 9 locations
Roux-en-Y vs. Roux-en-Y+ Pouch for D2 Total Gastrectomy

Gastric is one of the most prevalence digestive malignance tumors in China. Radical resection of primary tumors and combine with dissection of regional lymph-nodes is acknowledged by surgeons all over the world. Nowadays, in order to improve the quality of life, controversies still exist to the reconstruction methods of total …

adenocarcinoma
endoscopy
gastric adenocarcinoma
endoscopic biopsy
gastrectomy
  • 37 views
  • 22 Jan, 2021
  • 9 locations
PREACT Study: Locally Advanced Gastric Cancer, Chemoradiotherapy vs. Chemotherapy Followed by D2 Surgery and Adjuvant Chemotherapy (PREACT)

Although the incidence of gastric cancer has been substantially declining for several decades, it is still the sixth most common cancer and the fourth most frequent cause of cancer death worldwide. Surgery is still the only curative option for gastric cancer. However, most patients are unable to undergo surgery because …

adenocarcinoma
gastric cancer
pre-operative chemotherapy
immunomodulator
adjuvant chemotherapy
  • 22 views
  • 24 Feb, 2022
  • 1 location
A Study of Evorpacept (ALX148) in Patients With Advanced HER2+ Gastric Cancer (ASPEN-06)

A Phase 2/3 Study of Evorpacept (ALX148) in Combination With Trastuzumab, Ramucirumab, and Paclitaxel in Patients With Advanced HER2-overexpressing gastric/GEJ adenocarcinoma.

fluoropyrimidine
adenocarcinoma
trastuzumab
erbb2
cancer chemotherapy
  • 0 views
  • 22 Apr, 2022
  • 19 locations
Prophylactic Preoperative HIPEC in Advanced Gastric Cancer at High Risk of Peritoneal Recurrence

The study was designed to evaluate the efficacy of perioperative FLOT4 chemotherapy in combination with perioperative hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with advanced gastric cancer at high risk of peritoneal metastases. The impact of treatment on peritoneal recurrence and survival over 6 months, 1, 3 and 5 years will …

gastrectomy
cancer chemotherapy
irinotecan
  • 0 views
  • 03 Sep, 2021
  • 1 location