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Found 600 clinical trials
Long-term Follow-up of Interleukin-1B and H+,K+-ATPase mRNA Expression After Helicobacter Pylori Eradication

We will evaluate the long-term changes of gastric H+, K+-adenosine triphosphatase (H+, K+-ATPase) and Interleukin-1B mRNA expression according to Helicobacter pylori (H.pylori) infection and intestinal metaplasia and investigate the long-term effect of H. pylori eradication

gastric cancer
early gastric cancer
peptic ulcer
  • 14 Feb, 2022
  • 1 location
Q-GAIN (Using Qpop to Predict Treatment for GAstroIntestinal caNcer)

This is a multi-cohort proof of concept study involving patients with metastatic gastrointestinal cancers. In the first cohort of treatment-naïve patients, the investigators intend to create cancer organoids for 100 subjects. Then, the investigators intend to evaluate ex-vivo prediction of treatment outcomes using QPOP (see section 4.0 for detailed sample …

absolute neutrophil count
  • 23 Apr, 2022
  • 1 location
Helicobacter Pylori Atrophic Gastritis and Intestinal Metaplasia Registry and Prospective Study

Since much is unknown about factors that lead to progression of the pre-neoplastic lesions and cancer. In addition, there is ongoing debate on the optimal surveillance intervals and techniques. To solve these important clinical questions, we propose for the establishment of a registry for a longitudinal study with the hopes …

gastric cancer
  • 01 Oct, 2021
  • 2 locations
Pathogen-microbiome Interaction During Helicobacter Pylori Infection (PREDICTHP)

Helicobacter pylori affects the gut microbiome in ways that are only partially understood. In which patients H. pylori causes severe disease and in whom it merely colonizes, possibly even with beneficial effects, is not understood. The investigators are pursuing the hypothesis that changes in the gut microbiome that can be …

Accepts healthy volunteers
  • 03 Jun, 2022
  • 1 location
Patient-Derived Xenografts to Reduce Cancer Health Disparities

This trial establishes patient-derived cancer xenografts in addressing cancer health and treatment disparities that disproportionately affect racial/ethnic minorities. Understanding the genetic and response differences among racial/ethnic minorities may help researchers enhance the precision of therapeutic treatments.

lung carcinoma
lung cancer
bladder cancer
bladder tumor
primary cancer
  • 18 Jul, 2021
  • 2 locations
Utility of OverStitch Sx After ESD

This study is a prospective study where the investigators will make a database of all the patients who have received this procedure and will document various outcomes (i.e. number of sutures used, number of clips (if used), time required to close, complications/ issues). No changes will be done to the …

  • 27 Jun, 2022
  • 1 location
Circulating Tumor DNA as Marker for Response to Antineoplastic Treatment of Metastatic Cancer (FLUIDO)

Early monitoring of antineoplastic treatment benefit is a central medical need. Radiologic assessment for documentation of response is done after several months of treatment usually. This implies that patients not responding are exposed to unnecessary toxicity. According to several reports showing the correlation of the amount of circulating tumour DNA …

  • 18 Mar, 2021
  • 1 location
Expression of CXCL5 in Urinary Bladder Urothelial Carcinoma

Bladder carcinoma is the 9th most prevalent cancer worldwide and the 13th most common cause of cancer-related deaths. Approximately three quarters of all cases are diagnosed in men. Lack of understanding of mechanisms that govern bladder carcinoma metastasis and recurrence is a major reason for its high mortality rates. CXCL5 …

  • 08 Dec, 2021
  • 1 location
The Microbiome of Oesophageal Squamous Cell Carcinoma

This is a prospective study on the microbiota associated with oesophageal squamous cell carcinoma (SCC). Patients with newly diagnosed SCC of oesophagus would be recruited for taking samples of oral and oesophageal rinse, tissue biopsies for investigation of the microbiota of oesophageal cancer. Control patients would be identified from patients …

squamous cell carcinoma
esophagus cancer
  • 05 Aug, 2021
  • 1 location
Liquid Biopsy for ctDNA in Peritoneal Lavage and Blood in Pancreatic Cancer (LIPAC)

Pancreatic cancer (PC) is a deadly disease and surgical resection of the tumor is the only hope of cure. Approximately 20-25% of the PC patients are candidates for intended curative resection, but despite microscopically radical resection the majority of patients will have recurrent disease within 2 years. This indicates that …

cancer chemotherapy
pancreatic resection
  • 16 Jun, 2022
  • 1 location