Found 14 clinical trials
Evaluation of Impaired Mobility in Chronic Illness Constitution of a Cohort (EVALMOB)
Chronic illness is a public health issue and mobility loss is frequent in this population. Among its' multiple physical and psychological consequences, increased mortality and cardiovascular morbidity seem the main concern. Therefore, the exploration of locomotor deficiencies, physical capacities and metabolism of patients with chronic illnesses constitutes a major challenge …
- 0 views
- 25 Jan, 2022
- 1 location
Swedish Drug-elution Trial in Peripheral Arterial Disease
ischemic ulcers/gangrene (critical limb ischemia), putting the extremity at risk of amputation, to exercise-induced pain (intermittent claudication), limiting the patients daily activities. Invasive
- 46 views
- 26 Jan, 2021
- 1 location
Genotype-guided Strategy for Antithrombotic Treatment in Peripheral Arterial Disease. (GENPAD)
Rationale: Peripheral arterial disease (PAD) is a common presentation of atherosclerosis. For the prevention of adverse events related to arterial thrombosis in PAD patients, clopidogrel is recommended. Clopidogrel in itself is inactive and needs to be metabolized by cytochrome P450 2C19 (CYP2C19) into the active metabolite. About 30% of PAD …
- 0 views
- 29 Apr, 2022
- 5 locations
Treatment of No-option CLI by G-CSF-mobilized PB-MNC
pain, non-healing ischemic ulcer or gangrene will be randomized into 2 groups. The control group will be treated by medication and supportive treatment. The experiment group will be injected G-CSF
- 3 views
- 14 Feb, 2022
- 1 location
Study of the R3 Vascular Drug-Eluting Bioresorbable Scaffold in Treating Below the Knee Arterial Disease (RESOLV I)
patients, and may lead to amputation of the affected limb due to the loss of tissue in the leg or foot from ulcers or gangrene. The investigational device being studied in this trial is intended to restore
- 0 views
- 25 May, 2022
- 6 locations
A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation (CHAMP)
Patients undergoing semi-elective lower extremity major amputation from complications associated with atherosclerotic limb ischemia will received intra-muscular injections of allogeneic Mesenchymal Stromal Cells in the leg above and below the point of amputation to prevent ischemic wound complications after surgery and decrease the incidence of revision and further amputation. Cohort …
- 49 views
- 21 Oct, 2022
- 1 location
SHOWME-PAD (Peripheral Artery Disease)
The overall goal of SHOWME-PAD is to make the existing evidence-base on treatment outcomes -focusing on health status outcomes that reflect the patients' perspective - more transparently available to patients and providers, such that more informed, evidence-based shared treatment decisions occur. INTEGRITY-PAD has the potential to radically reorganize care delivery …
- 9 views
- 21 Apr, 2022
- 1 location
Retrograde Approach in Ambulatory Practice
analgesics, and trophic disorders (ulcers, gangrene), which may lead to amputation. The Rutherford classification groups the different clinical forms of this pathology. The classic risk factors of
- 0 views
- 04 Oct, 2022
- 2 locations
SKin and Soft Tissue Necrotizing INfections in the Intensive Care Unit: a Prospective Multi-national Cohort Study
Necrotizing soft-tissue infections (NSTI) are rare and life-threatening bacterial infections characterized by subcutaneous tissue, fascia or muscle necrosis. Few prospective studies have been performed and our current knowledge on NSTI is mostly derived from retrospective single center studies. The "SKin and soft tissue necrotizing INfections in the ICU" (SKIN-ICU) study …
- 0 views
- 30 Nov, 2021
- 1 location
The Sapienza University Mortality and Morbidity Events Rate (SUMMER) Study in Diabetes
This observational study is aimed at identifying new molecular promoters of mortality (and morbidity) in patients with type 2 diabetes mellitus (T2DM).
- 0 views
- 09 Oct, 2021
- 1 location
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