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Found 18 clinical trials
Evaluation of Impaired Mobility in Chronic Illness Constitution of a Cohort (EVALMOB)

Chronic illness is a public health issue and mobility loss is frequent in this population. Among its' multiple physical and psychological consequences, increased mortality and cardiovascular morbidity seem the main concern. Therefore, the exploration of locomotor deficiencies, physical capacities and metabolism of patients with chronic illnesses constitutes a major challenge …

chronic disease
  • 0 views
  • 25 Jan, 2022
  • 1 location
Swedish Drug-elution Trial in Peripheral Arterial Disease

ischemic ulcers/gangrene (critical limb ischemia), putting the extremity at risk of amputation, to exercise-induced pain (intermittent claudication), limiting the patients daily activities. Invasive

transluminal angioplasty
endovascular procedure
arteriopathy
ischemic ulcer
ischemia
  • 40 views
  • 26 Jan, 2021
  • 1 location
Genotype-guided Strategy for Antithrombotic Treatment in Peripheral Arterial Disease. (GENPAD)

Rationale: Peripheral arterial disease (PAD) is a common presentation of atherosclerosis. For the prevention of adverse events related to arterial thrombosis in PAD patients, clopidogrel is recommended. Clopidogrel in itself is inactive and needs to be metabolized by cytochrome P450 2C19 (CYP2C19) into the active metabolite. About 30% of PAD …

intermittent claudication
clopidogrel
atherosclerosis
gangrene
  • 0 views
  • 29 Apr, 2022
  • 5 locations
Treatment of No-option CLI by G-CSF-mobilized PB-MNC

pain, non-healing ischemic ulcer or gangrene will be randomized into 2 groups. The control group will be treated by medication and supportive treatment. The experiment group will be injected G-CSF

rest pain
ischemic ulcer
gangrene
granulocyte colony stimulating factor
  • 3 views
  • 14 Feb, 2022
  • 1 location
Towards the Use of Instrumented Tests for Screening the Risk of Falling in Patients With Chronic Illness. (DETECACTI)

In patients with chronic illness, screening for falls and their health consequences are major public health issues. Muscle weakness, gait and balance disorders are among the most common risk factors for falling. Assessing these parameters would thus be a crucial step in the evaluation of the risk of falling, allowing …

chronic disease
  • 0 views
  • 25 Jan, 2022
  • 1 location
Autologous Fat Grafting in the Treatment of Critical Limb Ischaemia

Critical Limb Ischaemia (CLI) is a condition characterized by chronic ischemic at-rest pain, ulcers, or gangrene for more than 2 weeks in one or both legs, attributable to objectively proven

  • 0 views
  • 19 Feb, 2021
  • 1 location
Study of the R3 Vascular Drug-Eluting Bioresorbable Scaffold in Treating Below the Knee Arterial Disease (RESOLV I)

patients, and may lead to amputation of the affected limb due to the loss of tissue in the leg or foot from ulcers or gangrene. The investigational device being studied in this trial is intended to restore

leg pain
angiography
gangrene
atherectomy
ischemia
  • 0 views
  • 25 May, 2022
  • 5 locations
A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation (CHAMP)

Patients undergoing semi-elective lower extremity major amputation from complications associated with atherosclerotic limb ischemia will received intra-muscular injections of allogeneic Mesenchymal Stromal Cells in the leg above and below the point of amputation to prevent ischemic wound complications after surgery and decrease the incidence of revision and further amputation.

limb ischemia
ischemic wound
ischemia
gangrene
  • 49 views
  • 25 Feb, 2022
  • 1 location
Subcutaneous Injections of Autologous ASC to Heal Digital Ulcers in Patients With Scleroderma.

Ischemic digital ulcers (DUs) are a frequent complication in systemic sclerosis with a major impact on hand function and quality of life. Digital injection of autologous cultured adipose-derived stromal constitutes a promising approach to treat scleroderma-induced refractory ischemic DUs where no alternative therapy is validated. The aim of this phase …

digital ulcer
scleroderma
follicle stimulating hormone
progressive systemic sclerosis
  • 0 views
  • 25 Jan, 2021
  • 6 locations
SHOWME-PAD (Peripheral Artery Disease)

The overall goal of SHOWME-PAD is to make the existing evidence-base on treatment outcomes -focusing on health status outcomes that reflect the patients' perspective - more transparently available to patients and providers, such that more informed, evidence-based shared treatment decisions occur. INTEGRITY-PAD has the potential to radically reorganize care delivery …

peripheral arterial diseases
angiography
arteriopathy
  • 9 views
  • 21 Apr, 2022
  • 1 location