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Found 6 clinical trials
Ganglioside and IBD

determine the efficacy of dietary ganglioside in improving disease activity indices in pediatric patients with IBD. Secondary objectives include demonstrating the effectiveness of dietary ganglioside for

ulceration
renal function
remission
colitis
ulcerative colitis
  • 0 views
  • 04 Oct, 2022
  • 1 location
GM1 Prophylaxis for Post-chemotherapy Cognitive Impairment in Patients With Early Operable Breast Cancer

The purpose of this study is to evaluate the prophylactic effects of Ganglioside-Monosialic Acid in post-chemotherapy cognitive impairment in patients with early operable breast cancer.

cyclophosphamide
doxorubicin
adjuvant chemotherapy
ductal carcinoma
carcinoma
  • 0 views
  • 09 Apr, 2022
  • 1 location
GM1 Prophylaxis for WBRT Related Cognitive Dysfunction

To evaluate the efficacy and safety of GM1 for preventing cognitive impairment related to whole brain radiotherapy in breast cancer patients with brain metastases. And explore the clinical and molecular parameter for predicting severe cognitive impairment induced by WBRT and gaining benefit from GM1. Primary Endpoint: the change of Hopkins …

cancer
alzheimer's disease
cognitive impairment
neutrophil count
whole-brain radiotherapy
  • 0 views
  • 11 Nov, 2021
  • 1 location
Multi-4SCAR-T Therapy Targeting Breast Cancer

The purpose of this study is to assess the feasibility, safety and efficacy of multiple 4th generation CAR-T cells targeting Her2, GD2, and CD44v6 surface antigen in breast cancer. Another goal of the study is to learn more about the activities of the multi-CAR T cells and their persistency in …

HER2
erbb2
  • 0 views
  • 24 Jan, 2021
  • 1 location
A Phase 1/2 Study of Intravenous Gene Transfer With an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 Gangliosidosis

Background GM1 gangliosidosis is a disorder that destroys nerve cells. It is fatal. There is no treatment. People with GM1 are deficient in a certain enzyme. A gene therapy may help the body make this enzyme. This could improve GM1 symptoms. Objective To test if a gene therapy helps Type …

  • 2 views
  • 04 Oct, 2022
  • 1 location
Natural History of Glycosphingolipid Storage Disorders and Glycoprotein Disorders

This study will evaluate children with glycosphingolipid (GSL) storage disorders to investigate brain changes that cause nervous system degeneration. No experimental treatments are offered in this study; participants will receive standard medical care for their disease. The information from this study may help researchers develop new therapies for these disorders …

deficiency
MRI
  • 76 views
  • 25 Oct, 2022
  • 1 location